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result sql = Do proton pump inhibitors attenuate the effect of aspirin on platelet aggregation? A randomized crossover study.
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result sql = It is common practice to coadminister proton pump inhibitors with aspirin to diminish the risk of upper gastrointestinal bleeding. This is the first study that investigated the potential impact of a proton pump inhibitor on aspirin effects on platelet aggregation. Twenty-four hypertensive subjects eligible for treatment with low-dose enteric-coated aspirin (LDECA) for primary prevention of cardiovascular disease were randomized to receive 100 mg LDECA or 100 mg LDECA plus 30 mg lansoprazole for 4 weeks. Then, participants were crossed over to the alternative regimen for another 4 weeks. Salicylic, gastrin, and pepsinogen I blood level counting were used to ensure adherence to treatment. Platelet aggregation was evaluated by light transmittance aggregometry and PFA100. The LDECA administration reduced arachidonic acid (P < 0.001), collagen (P < 0.01), and epinephrine (P < 0.001) tests. These changes paralleled an increase in collagen/epinephrine duration (P < 0.001) but not in collagen/adenosine diphosphate duration and platelet count. No significant difference was found in any of these platelets' function tests with LDECA alone versus LDECA plus lansoprazole. A significant increase in salicylic levels was observed in patients on LDECA as well as in those on LDECA plus lansoprazole, whereas gastrin and pepsinogen I levels were increased only when lansoprazole was added. These data suggest that the concomitant use of the lansoprazole at 30-mg daily does not influence the long-term effect of LDECA on platelet aggregation. Furthermore, they might imply that an interaction of LDECA with other proton pump inhibitors on platelet aggregation is unlikely.
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char = i;code = 105
char = b;code = 98
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char = t;code = 116
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char = t;code = 116
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char = e;code = 101
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char = e;code = 101
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char = f;code = 102
char = e;code = 101
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char = a;code = 97
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char = e;code = 101
char = l;code = 108
char = e;code = 101
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char = g;code = 103
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char = g;code = 103
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char = ?;code = 63
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char = A;code = 65
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char = z;code = 122
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char = s;code = 115
char = o;code = 111
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char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = y;code = 121
char = .;code = 46
result sql = Do proton pump inhibitors attenuate the effect of aspirin on platelet aggregation? A randomized crossover study.
char = t;code = 116
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = c;code = 99
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char = m;code = 109
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char = i;code = 105
char = c;code = 99
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char = r;code = 114
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char = o;code = 111
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char = i;code = 105
char = b;code = 98
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char = w;code = 119
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char = h;code = 104
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char = k;code = 107
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char = .;code = 46
char = ;code = 32
char = T;code = 84
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char = s;code = 115
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char = i;code = 105
char = s;code = 115
char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = f;code = 102
char = i;code = 105
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char = s;code = 115
char = t;code = 116
char = ;code = 32
char = s;code = 115
char = t;code = 116
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char = t;code = 116
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char = a;code = 97
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char = i;code = 105
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char = T;code = 84
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char = m;code = 109
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char = (;code = 40
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char = E;code = 69
char = C;code = 67
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char = e;code = 101
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char = e;code = 101
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char = t;code = 116
char = ;code = 32
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char = s;code = 115
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
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char = a;code = 97
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char = s;code = 115
char = o;code = 111
char = p;code = 112
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char = e;code = 101
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char = p;code = 112
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char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
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char = t;code = 116
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char = l;code = 108
char = e;code = 101
char = t;code = 116
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char = o;code = 111
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char = i;code = 105
char = s;code = 115
char = ;code = 32
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char = k;code = 107
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result sql = It is common practice to coadminister proton pump inhibitors with aspirin to diminish the risk of upper gastrointestinal bleeding. This is the first study that investigated the potential impact of a proton pump inhibitor on aspirin effects on platelet aggregation. Twenty-four hypertensive subjects eligible for treatment with low-dose enteric-coated aspirin (LDECA) for primary prevention of cardiovascular disease were randomized to receive 100 mg LDECA or 100 mg LDECA plus 30 mg lansoprazole for 4 weeks. Then, participants were crossed over to the alternative regimen for another 4 weeks. Salicylic, gastrin, and pepsinogen I blood level counting were used to ensure adherence to treatment. Platelet aggregation was evaluated by light transmittance aggregometry and PFA100. The LDECA administration reduced arachidonic acid (P < 0.001), collagen (P < 0.01), and epinephrine (P < 0.001) tests. These changes paralleled an increase in collagen/epinephrine duration (P < 0.001) but not in collagen/adenosine diphosphate duration and platelet count. No significant difference was found in any of these platelets' function tests with LDECA alone versus LDECA plus lansoprazole. A significant increase in salicylic levels was observed in patients on LDECA as well as in those on LDECA plus lansoprazole, whereas gastrin and pepsinogen I levels were increased only when lansoprazole was added. These data suggest that the concomitant use of the lansoprazole at 30-mg daily does not influence the long-term effect of LDECA on platelet aggregation. Furthermore, they might imply that an interaction of LDECA with other proton pump inhibitors on platelet aggregation is unlikely.
Publication: J. Cardiovasc. Pharmacol. 2009 Aug ;54(2)::163-8. :doi: 10.1097/FJC.0b013e3181af6d9c.
Publication Date: 2009 Aug
Study Author(s): Adamopoulos, Adam B;Sakizlis, George N;Nasothimiou, Efthimia G;Anastasopoulou, Ioanna;Anastasakou, Eugenia;Kotsi, Paraskevi;Karafoulidou, Anastasia;Stergiou, George S;
Institution: 3rd Department of Medicine, University of Athens, Sotiria Hospital, Athens 11527, Greece.
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Publication Date: 2009 Aug
Study Author(s): Adamopoulos, Adam B;Sakizlis, George N;Nasothimiou, Efthimia G;Anastasopoulou, Ioanna;Anastasakou, Eugenia;Kotsi, Paraskevi;Karafoulidou, Anastasia;Stergiou, George S;
Institution: 3rd Department of Medicine, University of Athens, Sotiria Hospital, Athens 11527, Greece.
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It is common practice to coadminister proton pump inhibitors with aspirin to diminish the risk of upper gastrointestinal bleeding. This is the first study that investigated the potential impact of a proton pump inhibitor on aspirin effects on platelet aggregation. Twenty-four hypertensive subjects eligible for treatment with low-dose enteric-coated aspirin (LDECA) for primary prevention of cardiovascular disease were randomized to receive 100 mg LDECA or 100 mg LDECA plus 30 mg lansoprazole for 4 weeks. Then, participants were crossed over to the alternative regimen for another 4 weeks. Salicylic, gastrin, and pepsinogen I blood level counting were used to ensure adherence to treatment. Platelet aggregation was evaluated by light transmittance aggregometry and PFA100. The LDECA administration reduced arachidonic acid (P < 0.001), collagen (P < 0.01), and epinephrine (P < 0.001) tests. These changes paralleled an increase in collagen/epinephrine duration (P < 0.001) but not in collagen/adenosine diphosphate duration and platelet count. No significant difference was found in any of these platelets' function tests with LDECA alone versus LDECA plus lansoprazole. A significant increase in salicylic levels was observed in patients on LDECA as well as in those on LDECA plus lansoprazole, whereas gastrin and pepsinogen I levels were increased only when lansoprazole was added. These data suggest that the concomitant use of the lansoprazole at 30-mg daily does not influence the long-term effect of LDECA on platelet aggregation. Furthermore, they might imply that an interaction of LDECA with other proton pump inhibitors on platelet aggregation is unlikely.
PMID: 19568178
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