|
|
char = A;code = 65
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char = n;code = 110
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char = i;code = 105
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char = r;code = 114
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char = o;code = 111
char = x;code = 120
char = i;code = 105
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char = i;code = 105
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char = y;code = 121
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char = a;code = 97
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char = c;code = 99
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char = s;code = 115
char = p;code = 112
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = -;code = 45
char = 3;code = 51
char = -;code = 45
char = d;code = 100
char = e;code = 101
char = p;code = 112
char = e;code = 101
char = n;code = 110
char = d;code = 100
char = e;code = 101
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char = ;code = 32
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char = i;code = 105
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char = a;code = 97
char = t;code = 116
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char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = p;code = 112
char = r;code = 114
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char = t;code = 116
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char = k;code = 107
char = i;code = 105
char = n;code = 110
char = a;code = 97
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char = e;code = 101
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char = C;code = 67
char = d;code = 100
char = e;code = 101
char = l;code = 108
char = t;code = 116
char = a;code = 97
char = .;code = 46
result sql = Androgens induce dopaminergic neurotoxicity via caspase-3-dependent activation of protein kinase Cdelta.
Androgens induce dopaminergic neurotoxicity via caspase-3-dependent activation of protein kinase Cdelta.char = A;code = 65
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char = e;code = 101
char = d;code = 100
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char = ;code = 32
char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = i;code = 105
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char = c;code = 99
char = i;code = 105
char = d;code = 100
char = e;code = 101
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char = ;code = 32
char = P;code = 80
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char = n;code = 110
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char = s;code = 115
char = e;code = 101
char = ;code = 32
char = (;code = 40
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char = D;code = 68
char = );code = 41
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char = o;code = 111
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char = ;code = 32
char = P;code = 80
char = D;code = 68
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char = t;code = 116
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char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = d;code = 100
char = o;code = 111
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char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = n;code = 110
char = e;code = 101
char = u;code = 117
char = r;code = 114
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
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char = n;code = 110
char = i;code = 105
char = g;code = 103
char = r;code = 114
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char = s;code = 115
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char = s;code = 115
char = t;code = 116
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char = ;code = 32
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char = h;code = 104
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char = n;code = 110
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char = o;code = 111
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char = f;code = 102
char = e;code = 101
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char = ;code = 32
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result sql = Aged men have a greater incidence of Parkinson's disease (PD) than women. PD is a neurodegenerative condition associated with the loss of dopamine neurons in the nigrostriatal pathway. This study examined the neurotoxic effects of androgens in a dopaminergic cell line (N27 cells) and the downstream signaling pathways activated by androgens. Treatment of N27 cells with testosterone- and dihydrotestosterone-induced mitochondrial dysfunction, protein kinase C (PKC)-delta cleavage, and apoptosis in dopaminergic neuronal cells. Inhibition of caspase-3 prevented the cleavage of PKCdelta from the full-length element to the catalytic fragment and apoptosis in N27 cells, suggesting that androgen-induced apoptosis is mediated by caspase-3-dependent activation of PKCdelta. Androgen-induced apoptosis may be specific to dopamine neurons as evidenced by a lack of testosterone-induced apoptosis in GnRH neurons. These results support a neurotoxic consequence of testosterone on dopaminergic neurons and may provide insight into the gender bias found in PD.
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result sql = Androgens induce dopaminergic neurotoxicity via caspase-3-dependent activation of protein kinase Cdelta.
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result sql = Aged men have a greater incidence of Parkinson's disease (PD) than women. PD is a neurodegenerative condition associated with the loss of dopamine neurons in the nigrostriatal pathway. This study examined the neurotoxic effects of androgens in a dopaminergic cell line (N27 cells) and the downstream signaling pathways activated by androgens. Treatment of N27 cells with testosterone- and dihydrotestosterone-induced mitochondrial dysfunction, protein kinase C (PKC)-delta cleavage, and apoptosis in dopaminergic neuronal cells. Inhibition of caspase-3 prevented the cleavage of PKCdelta from the full-length element to the catalytic fragment and apoptosis in N27 cells, suggesting that androgen-induced apoptosis is mediated by caspase-3-dependent activation of PKCdelta. Androgen-induced apoptosis may be specific to dopamine neurons as evidenced by a lack of testosterone-induced apoptosis in GnRH neurons. These results support a neurotoxic consequence of testosterone on dopaminergic neurons and may provide insight into the gender bias found in PD.
Publication: Endocrinology 2009 Dec ;150(12)::5539-48.
Publication Date: 2009 Dec
Study Author(s): Cunningham, Rebecca L;Giuffrida, Andrea;Roberts, James L;
Institution: Department of Pharmacology and the Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas 78229, USA. [email protected]
Shortcut link to this study:
Publication Date: 2009 Dec
Study Author(s): Cunningham, Rebecca L;Giuffrida, Andrea;Roberts, James L;
Institution: Department of Pharmacology and the Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, Texas 78229, USA. [email protected]
Shortcut link to this study:
Aged men have a greater incidence of Parkinson's disease (PD) than women. PD is a neurodegenerative condition associated with the loss of dopamine neurons in the nigrostriatal pathway. This study examined the neurotoxic effects of androgens in a dopaminergic cell line (N27 cells) and the downstream signaling pathways activated by androgens. Treatment of N27 cells with testosterone- and dihydrotestosterone-induced mitochondrial dysfunction, protein kinase C (PKC)-delta cleavage, and apoptosis in dopaminergic neuronal cells. Inhibition of caspase-3 prevented the cleavage of PKCdelta from the full-length element to the catalytic fragment and apoptosis in N27 cells, suggesting that androgen-induced apoptosis is mediated by caspase-3-dependent activation of PKCdelta. Androgen-induced apoptosis may be specific to dopamine neurons as evidenced by a lack of testosterone-induced apoptosis in GnRH neurons. These results support a neurotoxic consequence of testosterone on dopaminergic neurons and may provide insight into the gender bias found in PD.
PMID: 19837873
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