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char = z;code = 122
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char = (;code = 40
char = T;code = 84
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char = r;code = 114
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char = #;code = 35
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char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = p;code = 112
char = e;code = 101
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char = t;code = 116
char = a;code = 97
char = b;code = 98
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = X;code = 88
char = e;code = 101
char = l;code = 108
char = o;code = 111
char = d;code = 100
char = a;code = 97
char = &;code = 38
char = #;code = 35
char = 1;code = 49
char = 7;code = 55
char = 4;code = 52
char = ;;code = 59
char = );code = 41
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = g;code = 103
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
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char = v;code = 118
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = r;code = 114
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = o;code = 111
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = p;code = 112
char = h;code = 104
char = ;code = 32
char = p;code = 112
char = i;code = 105
char = t;code = 116
char = u;code = 117
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
char = r;code = 114
char = .;code = 46
result sql = Temozolomide (Temodar®) and capecitabine (Xeloda®) treatment of an aggressive corticotroph pituitary tumor.
Temozolomide (Temodar®) and capecitabine (Xeloda®) treatment of an aggressive corticotroph pituitary tumor.
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char = a;code = 97
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char = e;code = 101
char = l;code = 108
char = y;code = 121
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char = d;code = 100
char = o;code = 111
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = r;code = 114
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = o;code = 111
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = p;code = 112
char = h;code = 104
char = ;code = 32
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char = t;code = 116
char = u;code = 117
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char = a;code = 97
char = r;code = 114
char = y;code = 121
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char = a;code = 97
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char = o;code = 111
char = f;code = 102
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char = a;code = 97
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char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = n;code = 110
char = e;code = 101
char = r;code = 114
char = v;code = 118
char = e;code = 101
char = s;code = 115
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char = d;code = 100
char = ;code = 32
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char = l;code = 108
char = o;code = 111
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = s;code = 115
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char = r;code = 114
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char = c;code = 99
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = W;code = 87
char = h;code = 104
char = e;code = 101
char = n;code = 110
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char = a;code = 97
char = g;code = 103
char = g;code = 103
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = p;code = 112
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char = u;code = 117
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char = t;code = 116
char = a;code = 97
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char = e;code = 101
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char = d;code = 100
char = o;code = 111
char = c;code = 99
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char = m;code = 109
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char = ;code = 32
char = d;code = 100
char = o;code = 111
char = ;code = 32
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char = v;code = 118
char = e;code = 101
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char = p;code = 112
char = ,;code = 44
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char = c;code = 99
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char = a;code = 97
char = l;code = 108
char = ;code = 32
char = t;code = 116
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char = e;code = 101
char = a;code = 97
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char = m;code = 109
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char = i;code = 105
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char = s;code = 115
char = ;code = 32
char = a;code = 97
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char = o;code = 111
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char = m;code = 109
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char = c;code = 99
char = c;code = 99
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char = s;code = 115
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char = ;code = 32
char = A;code = 65
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char = 5;code = 53
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char = ;code = 32
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char = g;code = 103
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char = t;code = 116
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char = a;code = 97
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char = e;code = 101
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char = c;code = 99
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char = i;code = 105
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char = t;code = 116
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char = o;code = 111
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char = h;code = 104
char = ;code = 32
char = p;code = 112
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char = t;code = 116
char = u;code = 117
char = i;code = 105
char = t;code = 116
char = a;code = 97
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char = y;code = 121
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char = t;code = 116
char = u;code = 117
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char = o;code = 111
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char = ;code = 32
char = 2;code = 50
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char = y;code = 121
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char = ;code = 32
char = a;code = 97
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char = e;code = 101
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char = i;code = 105
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char = t;code = 116
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char = a;code = 97
char = l;code = 108
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char = p;code = 112
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char = e;code = 101
char = n;code = 110
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = .;code = 46
char = ;code = 32
char = H;code = 72
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = s;code = 115
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char = m;code = 109
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char = ;code = 32
char = f;code = 102
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char = i;code = 105
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char = e;code = 101
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char = o;code = 111
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char = ;code = 32
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char = o;code = 111
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char = m;code = 109
char = a;code = 97
char = x;code = 120
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char = a;code = 97
char = l;code = 108
char = ;code = 32
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char = c;code = 99
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char = c;code = 99
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char = t;code = 116
char = o;code = 111
char = ;code = 32
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char = e;code = 101
char = s;code = 115
char = p;code = 112
char = o;code = 111
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result sql = Only rarely do corticotroph pituitary tumors become invasive leading to symptoms caused by compression of cranial nerves and other local structures. When aggressive pituitary neuroendocrine tumors do develop, conventional treatment options are of limited success. A 50-year-old man developed a giant invasive corticotroph pituitary tumor 2 years after initial presentation. His tumor and symptoms failed to respond to maximal surgical, radio-surgical, radiation and medical therapy and a bilateral adrenalectomy was done. He subsequently developed rapid growth of his tumor leading to multiple cranial nerve deficits. He was administered salvage chemotherapy with capecitabine and temozolomide (CAPTEM), a novel oral chemotherapy regimen developed at our institution for treatment of neuroendocrine tumors. After two cycles of CAPTEM, his tumor markedly decreased in size and ACTH levels fell by almost 90%. Despite further decreases in ACTH levels, his tumor recurred after 5 months with increased avidity on PET scan suggesting a transformation to a more aggressive phenotype. Temozolomide had been reported to be effective against other pituitary tumors and this case adds to this literature demonstrating its use along with capecitabine (CAPTEM) against a corticotroph tumor. Further evaluation of the CAPTEM regimen in patients with pituitary neuroendocrine tumors which fail to respond to classic treatments is warranted.

Publication: Pituitary 2011 Dec ;14(4)::418-24. :doi: 10.1007/s11102-009-0211-1.
Publication Date: 2011 Dec
Study Author(s): Thearle, Marie S;Freda, Pamela U;Bruce, Jeffrey N;Isaacson, Steven R;Lee, Yoomi;Fine, Robert L;
Institution: Department of Medicine, Division of Medical Oncology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Shortcut link to this study:
Only rarely do corticotroph pituitary tumors become invasive leading to symptoms caused by compression of cranial nerves and other local structures. When aggressive pituitary neuroendocrine tumors do develop, conventional treatment options are of limited success. A 50-year-old man developed a giant invasive corticotroph pituitary tumor 2 years after initial presentation. His tumor and symptoms failed to respond to maximal surgical, radio-surgical, radiation and medical therapy and a bilateral adrenalectomy was done. He subsequently developed rapid growth of his tumor leading to multiple cranial nerve deficits. He was administered salvage chemotherapy with capecitabine and temozolomide (CAPTEM), a novel oral chemotherapy regimen developed at our institution for treatment of neuroendocrine tumors. After two cycles of CAPTEM, his tumor markedly decreased in size and ACTH levels fell by almost 90%. Despite further decreases in ACTH levels, his tumor recurred after 5 months with increased avidity on PET scan suggesting a transformation to a more aggressive phenotype. Temozolomide had been reported to be effective against other pituitary tumors and this case adds to this literature demonstrating its use along with capecitabine (CAPTEM) against a corticotroph tumor. Further evaluation of the CAPTEM regimen in patients with pituitary neuroendocrine tumors which fail to respond to classic treatments is warranted.
PMID: 19960369

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