|
|
char = I;code = 73
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
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char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
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char = r;code = 114
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char = p;code = 112
char = r;code = 114
char = o;code = 111
char = g;code = 103
char = r;code = 114
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char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = b;code = 98
char = y;code = 121
char = ;code = 32
char = r;code = 114
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char = f;code = 102
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char = m;code = 109
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char = i;code = 105
char = c;code = 99
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char = n;code = 110
char = :;code = 58
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = v;code = 118
char = o;code = 111
char = l;code = 108
char = v;code = 118
char = e;code = 101
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = n;code = 110
char = g;code = 103
char = i;code = 105
char = o;code = 111
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char = e;code = 101
char = n;code = 110
char = i;code = 105
char = c;code = 99
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char = n;code = 110
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = n;code = 110
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char = -;code = 45
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char = u;code = 117
char = m;code = 109
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = .;code = 46
result sql = Inhibition of cancer progression by rifampicin: involvement of antiangiogenic and anti-tumor effects.
Inhibition of cancer progression by rifampicin: involvement of antiangiogenic and anti-tumor effects.char = V;code = 86
char = e;code = 101
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = c;code = 99
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char = n;code = 110
char = t;code = 116
char = l;code = 108
char = y;code = 121
char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = e;code = 101
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char = r;code = 114
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char = o;code = 111
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char = e;code = 101
char = d;code = 100
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char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
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char = n;code = 110
char = ;code = 32
char = a;code = 97
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char = i;code = 105
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char = b;code = 98
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char = l;code = 108
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char = s;code = 115
char = ;code = 32
char = a;code = 97
char = g;code = 103
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char = e;code = 101
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char = f;code = 102
char = e;code = 101
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char = o;code = 111
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char = s;code = 115
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = l;code = 108
char = o;code = 111
char = w;code = 119
char = ;code = 32
char = d;code = 100
char = o;code = 111
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = r;code = 114
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char = f;code = 102
char = e;code = 101
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char = f;code = 102
char = a;code = 97
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char = p;code = 112
char = i;code = 105
char = c;code = 99
char = i;code = 105
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char = t;code = 116
char = o;code = 111
char = ;code = 32
char = r;code = 114
char = a;code = 97
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char = i;code = 105
char = d;code = 100
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char = y;code = 121
char = ;code = 32
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char = n;code = 110
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char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = g;code = 103
char = i;code = 105
char = o;code = 111
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char = e;code = 101
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char = e;code = 101
char = s;code = 115
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char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
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char = m;code = 109
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char = e;code = 101
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char = i;code = 105
char = s;code = 115
char = -;code = 45
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char = d;code = 100
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char = g;code = 103
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char = e;code = 101
char = s;code = 115
char = ;code = 32
char = i;code = 105
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char = c;code = 99
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char = l;code = 108
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char = u;code = 117
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char = e;code = 101
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char = ;code = 32
char = e;code = 101
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char = a;code = 97
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char = c;code = 99
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char = l;code = 108
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char = r;code = 114
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char = m;code = 109
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char = c;code = 99
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char = o;code = 111
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char = ;code = 32
char = e;code = 101
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char = d;code = 100
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char = s;code = 115
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = ,;code = 44
char = ;code = 32
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char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = -;code = 45
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
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char = g;code = 103
char = e;code = 101
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char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = o;code = 111
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char = s;code = 115
char = .;code = 46
char = ;code = 32
char = H;code = 72
char = o;code = 111
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char = e;code = 101
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = ,;code = 44
char = ;code = 32
char = r;code = 114
char = i;code = 105
char = f;code = 102
char = a;code = 97
char = m;code = 109
char = p;code = 112
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = b;code = 98
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char = l;code = 108
char = i;code = 105
char = a;code = 97
char = r;code = 114
char = y;code = 121
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char = c;code = 99
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char = t;code = 116
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char = s;code = 115
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char = s;code = 115
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char = e;code = 101
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char = e;code = 101
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char = f;code = 102
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char = a;code = 97
char = l;code = 108
char = ;code = 32
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char = l;code = 108
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char = a;code = 97
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char = i;code = 105
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char = n;code = 110
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char = r;code = 114
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char = .;code = 46
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char = S;code = 83
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result sql = Very recently, we reported that an antituberculous agent, rifampicin, exerts potent inhibitory effects on hepatic tumors when administered orally at low doses. The in vitro effects of rifampicin to rapidly downregulate angiogenesis and mitogenesis-related genes in cultured endothelial cells are reminiscent of endostatin, one of the most well-studied angiogenesis inhibitors. However, rifampicin at the expected hepatobiliary concentrations after low oral doses showed more complete antiproliferative effects on endothelial cells, which make rifampicin favorable as an adjunct anticancer regimen. Since rifampicin undergoes hepatic accumulation resulting from the enterohepatic circulation, it may be especially beneficial for targeting hepatobiliary tumors. In the present paper, we extend our observations on the antiangiogenic properties of rifampicin and further elaborate on its direct antitumor effects on a variety of human cancer-derived cells.
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char = c;code = 99
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char = r;code = 114
char = o;code = 111
char = g;code = 103
char = r;code = 114
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char = s;code = 115
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char = c;code = 99
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char = n;code = 110
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char = f;code = 102
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result sql = Inhibition of cancer progression by rifampicin: involvement of antiangiogenic and anti-tumor effects.
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char = a;code = 97
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char = y;code = 121
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = n;code = 110
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char = a;code = 97
char = l;code = 108
char = ;code = 32
char = f;code = 102
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char = a;code = 97
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char = y;code = 121
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char = m;code = 109
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char = a;code = 97
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char = n;code = 110
char = ;code = 32
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char = c;code = 99
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char = t;code = 116
char = u;code = 117
char = m;code = 109
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result sql = Very recently, we reported that an antituberculous agent, rifampicin, exerts potent inhibitory effects on hepatic tumors when administered orally at low doses. The in vitro effects of rifampicin to rapidly downregulate angiogenesis and mitogenesis-related genes in cultured endothelial cells are reminiscent of endostatin, one of the most well-studied angiogenesis inhibitors. However, rifampicin at the expected hepatobiliary concentrations after low oral doses showed more complete antiproliferative effects on endothelial cells, which make rifampicin favorable as an adjunct anticancer regimen. Since rifampicin undergoes hepatic accumulation resulting from the enterohepatic circulation, it may be especially beneficial for targeting hepatobiliary tumors. In the present paper, we extend our observations on the antiangiogenic properties of rifampicin and further elaborate on its direct antitumor effects on a variety of human cancer-derived cells.
Publication: Cell Cycle 2010 Jan 1 ;9(1)::64-68.
Publication Date: 2010 Jan 1
Study Author(s): Shichiri, Masayoshi;Tanaka, Yujiro;
Institution: Tokyo Medical and Dental University Medical School; Tokyo, Japan. [email protected]
Shortcut link to this study:
Publication Date: 2010 Jan 1
Study Author(s): Shichiri, Masayoshi;Tanaka, Yujiro;
Institution: Tokyo Medical and Dental University Medical School; Tokyo, Japan. [email protected]
Shortcut link to this study:
Very recently, we reported that an antituberculous agent, rifampicin, exerts potent inhibitory effects on hepatic tumors when administered orally at low doses. The in vitro effects of rifampicin to rapidly downregulate angiogenesis and mitogenesis-related genes in cultured endothelial cells are reminiscent of endostatin, one of the most well-studied angiogenesis inhibitors. However, rifampicin at the expected hepatobiliary concentrations after low oral doses showed more complete antiproliferative effects on endothelial cells, which make rifampicin favorable as an adjunct anticancer regimen. Since rifampicin undergoes hepatic accumulation resulting from the enterohepatic circulation, it may be especially beneficial for targeting hepatobiliary tumors. In the present paper, we extend our observations on the antiangiogenic properties of rifampicin and further elaborate on its direct antitumor effects on a variety of human cancer-derived cells.
PMID: 20016271
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