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result sql = Associations of polymorphisms of eight muscle- or metabolism-related genes with performance in Mount Olympus marathon runners.

Associations of polymorphisms of eight muscle- or metabolism-related genes with performance in Mount Olympus marathon runners.

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char = e;code = 101
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char = n;code = 110
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char = A;code = 65
char = C;code = 67
char = T;code = 84
char = N;code = 78
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char = ,;code = 44
char = ;code = 32
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char = a;code = 97
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char = A;code = 65
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char = 2;code = 50
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char = c;code = 99
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char = p;code = 112
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char = B;code = 66
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char = ,;code = 44
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char = a;code = 97
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char = a;code = 97
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char = a;code = 97
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char = c;code = 99
char = e;code = 101
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char = r;code = 114
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char = P;code = 80
char = P;code = 80
char = A;code = 65
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char = g;code = 103
char = a;code = 97
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char = m;code = 109
char = a;code = 97
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char = v;code = 118
char = a;code = 97
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char = a;code = 97
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char = P;code = 80
char = P;code = 80
char = A;code = 65
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char = G;code = 71
char = C;code = 67
char = 1;code = 49
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char = ,;code = 44
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char = P;code = 80
char = P;code = 80
char = A;code = 65
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char = a;code = 97
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char = P;code = 80
char = A;code = 65
char = R;code = 82
char = A;code = 65
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char = ,;code = 44
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char = P;code = 80
char = P;code = 80
char = A;code = 65
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char = a;code = 97
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char = P;code = 80
char = A;code = 65
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char = D;code = 68
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char = ,;code = 44
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char = a;code = 97
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char = ;code = 32
char = (;code = 40
char = A;code = 65
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char = O;code = 79
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char = r;code = 114
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char = u;code = 117
char = a;code = 97
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char = .;code = 46
char = ;code = 32
char = H;code = 72
char = a;code = 97
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char = d;code = 100
char = y;code = 121
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char = W;code = 87
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char = B;code = 66
char = 2;code = 50
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char = r;code = 114
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char = 9;code = 57
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char = 0;code = 48
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char = T;code = 84
char = T;code = 84
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char = g;code = 103
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char = 4;code = 52
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char = R;code = 82
char = B;code = 66
char = 2;code = 50
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char = r;code = 114
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char = 1;code = 49
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char = );code = 41
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char = l;code = 108
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char = l;code = 108
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = i;code = 105
char = m;code = 109
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = (;code = 40
char = P;code = 80
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 1;code = 49
char = );code = 41
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = v;code = 118
char = i;code = 105
char = o;code = 111
char = u;code = 117
char = s;code = 115
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = B;code = 66
char = D;code = 68
char = K;code = 75
char = R;code = 82
char = B;code = 66
char = 2;code = 50
char = ;code = 32
char = r;code = 114
char = s;code = 115
char = 1;code = 49
char = 7;code = 55
char = 9;code = 57
char = 9;code = 57
char = 7;code = 55
char = 2;code = 50
char = 2;code = 50
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = A;code = 65
char = D;code = 68
char = R;code = 82
char = B;code = 66
char = 2;code = 50
char = ;code = 32
char = r;code = 114
char = s;code = 115
char = 1;code = 49
char = 0;code = 48
char = 4;code = 52
char = 2;code = 50
char = 7;code = 55
char = 1;code = 49
char = 3;code = 51
char = ,;code = 44
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = y;code = 121
char = .;code = 46
char = ;code = 32
char = B;code = 66
char = D;code = 68
char = K;code = 75
char = R;code = 82
char = B;code = 66
char = 2;code = 50
char = ;code = 32
char = r;code = 114
char = s;code = 115
char = 1;code = 49
char = 7;code = 55
char = 9;code = 57
char = 9;code = 57
char = 7;code = 55
char = 2;code = 50
char = 2;code = 50
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = A;code = 65
char = D;code = 68
char = R;code = 82
char = B;code = 66
char = 2;code = 50
char = ;code = 32
char = r;code = 114
char = s;code = 115
char = 1;code = 49
char = 0;code = 48
char = 4;code = 52
char = 2;code = 50
char = 7;code = 55
char = 1;code = 49
char = 3;code = 51
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = o;code = 111
char = m;code = 109
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = p;code = 112
char = o;code = 111
char = r;code = 114
char = t;code = 116
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = p;code = 112
char = l;code = 108
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = e;code = 101
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = m;code = 109
char = o;code = 111
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = u;code = 117
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = r;code = 114
char = u;code = 117
char = n;code = 110
char = n;code = 110
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = q;code = 113
char = u;code = 117
char = i;code = 105
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = u;code = 117
char = r;code = 114
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = v;code = 118
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = g;code = 103
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
char = <;code = 60
char = b;code = 98
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char = /;code = 47
char = >;code = 62
result sql = Athletic endurance performance is probably partly under genetic control, but genetic association studies have yielded inconclusive results. The objective of the present study was to evaluate the association of polymorphisms in eight muscle- or metabolism-related genes with endurance performance in participants of the Olympus Marathon running race. We recruited 438 athletes who participated in the 2007 and 2008 annual running events of the OLYMPUS MARATHON: a 43.8-km race with an ascent from sea level to 2,690-m altitude and then a descent to 300 m. Phenotypes of interest were the competitive event time at the specific Olympus Marathon where the athlete was enrolled, the fastest reported timing ever achieved in an Olympus Marathon, and how many kilometers per week the athlete ran during the previous year. Eleven polymorphisms in alpha(3)-actinin (ACTN3), AMP deaminase-1 (AMPD1), bradykinin B(2) receptor (BDKRB2), beta(2)-adrenergic receptor (ADRB2), peroxisome proliferator-activated receptor (PPAR)-gamma coactivator-1 alpha (PPARGC1A), PPAR-alpha (PPARA), PPAR-delta (PPARD), and apoliprotein E (APOE) were evaluated. Hardy-Weinberg equilibrium testing on the overall cohort of male athletes showed a significant deviation for BDKRB2 rs1799722 (P = 0.018; P = 0.006 when limited to 316 habitual male runners) with an excess of the TT genotype. Across all athletes, no associations showed nominal statistical significance for any of the three phenotypes, and the same was true when analyses were limited to men (n = 417). When limited to 316 male athletes who identified running as their preferred sport, ADRB2 rs1042713 had nominally significant associations with faster times for the minor (A) allele for the fastest time ever (P = 0.01). The direction of effect was identical as previously postulated only for BDKRB2 rs1799722 and ADRB2 rs1042713, indicating consistency. BDKRB2 rs1799722 and ADRB2 rs1042713 have some support for being implicated in endurance performance among habitual runners and require further investigation.

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