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result sql = Cost-effectiveness of a hydroquinone/tretinoin/fluocinolone acetonide cream combination in treating melasma in the United States.
Cost-effectiveness of a hydroquinone/tretinoin/fluocinolone acetonide cream combination in treating melasma in the United States.
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char = l;code = 108
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char = o;code = 111
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char = e;code = 101
char = ,;code = 44
char = ;code = 32
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char = C;code = 67
char = E;code = 69
char = R;code = 82
char = s;code = 115
char = ;code = 32
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char = e;code = 101
char = r;code = 114
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char = ;code = 32
char = l;code = 108
char = o;code = 111
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char = ,;code = 44
char = ;code = 32
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char = ;code = 32
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char = t;code = 116
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char = C;code = 67
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char = m;code = 109
char = a;code = 97
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char = i;code = 105
char = n;code = 110
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char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = a;code = 97
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char = ;code = 32
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char = p;code = 112
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = a;code = 97
char = n;code = 110
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char = ;code = 32
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char = d;code = 100
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char = ;code = 32
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char = r;code = 114
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = q;code = 113
char = u;code = 117
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = n;code = 110
char = e;code = 101
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result sql = BACKGROUND : Melasma, a disorder of facial hyperpigmentation, presents a treatment obstacle to many physicians. Combination therapy with hydroquinone, tretinoin, and fluocinolone acetonide has proven effective, but it is generally more expensive than other treatments.

OBJECTIVE : To assess the cost-effectiveness of daily triple combination therapy (TCT) compared with daily use of each possible pair of agents (dyads) and twice daily use of hydroquinone (HQ) alone from a payer's perspective.

METHODS : Efficacy data were obtained from two clinical trials with the primary endpoint being complete clearance at 8 weeks. For all treatments, total cost per successful treatment was calculated. The incremental cost-effectiveness ratio (ICER) was calculated for each dyad and for HQ monotherapy in comparison with TCT. Sensitivity analyses for efficacy and number of office visits were similarly performed.

RESULTS AND CONCLUSION : TCT consistently had the lowest cost per primary success in all the analyses performed. Furthermore, ICERs were low, indicating that TCT's superior efficacy is attained at marginal cost increases. Our results indicate that TCT is the most cost-effective treatment when compared with any of its dyads or with hydroquinone alone.

Publication: J Dermatolog Treat 2010 Sep ;21(5)::276-81. :doi: 10.3109/09546630903200612.
Publication Date: 2010 Sep
Study Author(s): Alikhan, Ali;Daly, Meaghan;Wu, Jun;Balkrishnan, Rajesh;Feldman, Steven R;
Institution: School of Medicine, University of California at Davis, Sacramento, California, USA. [email protected]
Shortcut link to this study:
BACKGROUND : Melasma, a disorder of facial hyperpigmentation, presents a treatment obstacle to many physicians. Combination therapy with hydroquinone, tretinoin, and fluocinolone acetonide has proven effective, but it is generally more expensive than other treatments.

OBJECTIVE : To assess the cost-effectiveness of daily triple combination therapy (TCT) compared with daily use of each possible pair of agents (dyads) and twice daily use of hydroquinone (HQ) alone from a payer's perspective.

METHODS : Efficacy data were obtained from two clinical trials with the primary endpoint being complete clearance at 8 weeks. For all treatments, total cost per successful treatment was calculated. The incremental cost-effectiveness ratio (ICER) was calculated for each dyad and for HQ monotherapy in comparison with TCT. Sensitivity analyses for efficacy and number of office visits were similarly performed.

RESULTS AND CONCLUSION : TCT consistently had the lowest cost per primary success in all the analyses performed. Furthermore, ICERs were low, indicating that TCT's superior efficacy is attained at marginal cost increases. Our results indicate that TCT is the most cost-effective treatment when compared with any of its dyads or with hydroquinone alone.
PMID: 20055711

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