|
|
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result sql = Molecular genetics and phenomics of RET mutations: Impact on prognosis of MTC.
Molecular genetics and phenomics of RET mutations: Impact on prognosis of MTC.char = M;code = 77
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char = o;code = 111
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char = e;code = 101
char = d;code = 100
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char = a;code = 97
char = r;code = 114
char = y;code = 121
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char = M;code = 77
char = T;code = 84
char = C;code = 67
char = .;code = 46
char = ;code = 32
char = M;code = 77
char = E;code = 69
char = N;code = 78
char = ;code = 32
char = 2;code = 50
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = v;code = 118
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = u;code = 117
char = n;code = 110
char = i;code = 105
char = q;code = 113
char = u;code = 117
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = d;code = 100
char = e;code = 101
char = l;code = 108
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
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char = n;code = 110
char = c;code = 99
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char = r;code = 114
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char = n;code = 110
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = m;code = 109
char = u;code = 117
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = -;code = 45
char = b;code = 98
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = ;code = 32
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char = a;code = 97
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char = o;code = 111
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char = s;code = 115
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char = n;code = 110
char = d;code = 100
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = y;code = 121
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = r;code = 114
char = i;code = 105
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant hereditary cancer syndrome caused by missense gain-of-function mutations of the RET proto-oncogene. Three distinct clinical subtypes of MEN 2 have been characterized: MEN 2A, MEN 2B, and familial medullary thyroid carcinoma (FMTC). The specific RET mutation may suggest a predilection toward a particular phenotype and clinical course, with strong genotype-phenotype correlations. Recommendations on the timing of prophylactic thyroidectomy and extent of surgery are based on classification of RET mutations into risk levels according to genotype-phenotype correlations. The excellent prognosis for MTC diagnosed at its earliest stage underscores the importance of prospective screening (calcitonin screening) for sporadic MTC and early diagnosis by RET-mutation analysis for hereditary MTC. MEN 2 provides a unique model for early prevention and cure of cancer and for the roles of stratified mutation-based diagnosis and therapy of carriers.
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = h;code = 104
char = e;code = 101
char = n;code = 110
char = o;code = 111
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = R;code = 82
char = E;code = 69
char = T;code = 84
char = ;code = 32
char = m;code = 109
char = u;code = 117
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = :;code = 58
char = ;code = 32
char = I;code = 73
char = m;code = 109
char = p;code = 112
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = p;code = 112
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char = o;code = 111
char = g;code = 103
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char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = M;code = 77
char = T;code = 84
char = C;code = 67
char = .;code = 46
result sql = Molecular genetics and phenomics of RET mutations: Impact on prognosis of MTC.
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char = t;code = 116
char = i;code = 105
char = p;code = 112
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char = n;code = 110
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char = f;code = 102
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char = M;code = 77
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char = N;code = 78
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char = ;code = 32
char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
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char = b;code = 98
char = e;code = 101
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char = c;code = 99
char = h;code = 104
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char = a;code = 97
char = c;code = 99
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char = r;code = 114
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char = z;code = 122
char = e;code = 101
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char = l;code = 108
char = a;code = 97
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char = y;code = 121
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char = h;code = 104
char = y;code = 121
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char = d;code = 100
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char = c;code = 99
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char = o;code = 111
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char = a;code = 97
char = ;code = 32
char = (;code = 40
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char = T;code = 84
char = C;code = 67
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char = .;code = 46
char = ;code = 32
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char = p;code = 112
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char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
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char = R;code = 82
char = E;code = 69
char = T;code = 84
char = ;code = 32
char = m;code = 109
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char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = a;code = 97
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char = ;code = 32
char = s;code = 115
char = u;code = 117
char = g;code = 103
char = g;code = 103
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char = s;code = 115
char = t;code = 116
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = i;code = 105
char = l;code = 108
char = e;code = 101
char = c;code = 99
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char = i;code = 105
char = o;code = 111
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char = t;code = 116
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char = w;code = 119
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char = d;code = 100
char = ;code = 32
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char = p;code = 112
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char = a;code = 97
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char = c;code = 99
char = o;code = 111
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char = s;code = 115
char = e;code = 101
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char = t;code = 116
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char = t;code = 116
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char = k;code = 107
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result sql = Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant hereditary cancer syndrome caused by missense gain-of-function mutations of the RET proto-oncogene. Three distinct clinical subtypes of MEN 2 have been characterized: MEN 2A, MEN 2B, and familial medullary thyroid carcinoma (FMTC). The specific RET mutation may suggest a predilection toward a particular phenotype and clinical course, with strong genotype-phenotype correlations. Recommendations on the timing of prophylactic thyroidectomy and extent of surgery are based on classification of RET mutations into risk levels according to genotype-phenotype correlations. The excellent prognosis for MTC diagnosed at its earliest stage underscores the importance of prospective screening (calcitonin screening) for sporadic MTC and early diagnosis by RET-mutation analysis for hereditary MTC. MEN 2 provides a unique model for early prevention and cure of cancer and for the roles of stratified mutation-based diagnosis and therapy of carriers.
Publication: Mol. Cell. Endocrinol. 2010 Jun 30 ;322(1-2)::2-7. :doi: 10.1016/j.mce.2010.01.012.
Publication Date: 2010 Jun 30
Study Author(s): Frank-Raue, Karin;Rondot, Susanne;Raue, Friedhelm;
Institution: Endocrine Practice, Molecular Laboratory, Brueckenstr. 21, Heidelberg 69120, Germany. karin.frankraue@raue-endokrinologie.de
Shortcut link to this study:
Publication Date: 2010 Jun 30
Study Author(s): Frank-Raue, Karin;Rondot, Susanne;Raue, Friedhelm;
Institution: Endocrine Practice, Molecular Laboratory, Brueckenstr. 21, Heidelberg 69120, Germany. karin.frankraue@raue-endokrinologie.de
Shortcut link to this study:
Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant hereditary cancer syndrome caused by missense gain-of-function mutations of the RET proto-oncogene. Three distinct clinical subtypes of MEN 2 have been characterized: MEN 2A, MEN 2B, and familial medullary thyroid carcinoma (FMTC). The specific RET mutation may suggest a predilection toward a particular phenotype and clinical course, with strong genotype-phenotype correlations. Recommendations on the timing of prophylactic thyroidectomy and extent of surgery are based on classification of RET mutations into risk levels according to genotype-phenotype correlations. The excellent prognosis for MTC diagnosed at its earliest stage underscores the importance of prospective screening (calcitonin screening) for sporadic MTC and early diagnosis by RET-mutation analysis for hereditary MTC. MEN 2 provides a unique model for early prevention and cure of cancer and for the roles of stratified mutation-based diagnosis and therapy of carriers.
PMID: 20083156
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