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char = w;code = 119
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char = a;code = 97
char = t;code = 116
char = u;code = 117
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char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = g;code = 103
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char = b;code = 98
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char = e;code = 101
char = r;code = 114
char = ;code = 32
char = r;code = 114
char = i;code = 105
char = s;code = 115
char = k;code = 107
char = .;code = 46
result sql = Interaction between menopausal status and obesity in affecting breast cancer risk.
Interaction between menopausal status and obesity in affecting breast cancer risk.
char = O;code = 79
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char = s;code = 115
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char = ;code = 32
char = a;code = 97
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
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char = e;code = 101
char = x;code = 120
char = ;code = 32
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char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = s;code = 115
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char = i;code = 105
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char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = r;code = 114
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char = t;code = 116
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char = f;code = 102
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char = m;code = 109
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char = m;code = 109
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char = .;code = 46
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char = B;code = 66
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char = e;code = 101
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char = h;code = 104
char = e;code = 101
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char = l;code = 108
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char = e;code = 101
char = l;code = 108
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
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char = i;code = 105
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = s;code = 115
char = ;code = 32
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char = t;code = 116
char = h;code = 104
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char = o;code = 111
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char = s;code = 115
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char = m;code = 109
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char = o;code = 111
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char = d;code = 100
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char = i;code = 105
char = z;code = 122
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char = d;code = 100
char = ;code = 32
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char = r;code = 114
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char = g;code = 103
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char = d;code = 100
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char = i;code = 105
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char = n;code = 110
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char = a;code = 97
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char = l;code = 108
char = ;code = 32
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char = a;code = 97
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char = t;code = 116
char = ;code = 32
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char = s;code = 115
char = ;code = 32
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char = f;code = 102
char = ;code = 32
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char = e;code = 101
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char = g;code = 103
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char = c;code = 99
char = o;code = 111
char = n;code = 110
char = t;code = 116
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char = o;code = 111
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = r;code = 114
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char = a;code = 97
char = r;code = 114
char = d;code = 100
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char = s;code = 115
char = s;code = 115
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char = f;code = 102
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = o;code = 111
char = p;code = 112
char = a;code = 97
char = u;code = 117
char = s;code = 115
char = a;code = 97
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char = ;code = 32
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = u;code = 117
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char = >;code = 62
result sql = Obesity has a complex relationship to breast cancer risk that differs in premenopausal and postmenopausal women. Before the menopause, the level of adiposity is inversely related to risk, indicative of a protective effect, whereas in postmenopausal women, particularly the elderly, the association is a positive one, consistent with obesity being a risk factor. The importance of high estrogen production in adipose tissue, with consequent elevation of circulating biologically available estradiol, in the promotional effect of obesity on postmenopausal breast carcinogenesis is well established; the resulting tumors express both estrogen and progesterone receptors. The mechanism(s) for the protective effect in premenopausal women is less well understood, but the breast cancers that do develop in the presence of obesity are most often estrogen and progesterone receptor negative, consistent with the selection of non-estrogen-dependent tumor cells which are dependent on growth factors such as insulin, insulin-like growth factor-I and some adipokines. The influence of menopausal status on the relationships between adiposity and breast cancer appears to be modified within each category by age; the protective effect before the menopause may be limited to younger women (<35 years), and the adverse effect was found to apply specifically to older postmenopausal women. Although randomized trials of weight reduction for postmenopausal breast cancer prevention have not been performed, observational studies suggested that risk reduction does occur; in addition, other health benefits of weight control need to be considered regardless of menopausal status.

Publication: Maturitas 2010 May ;66(1)::33-8. :doi: 10.1016/j.maturitas.2010.01.019.
Publication Date: 2010 May
Study Author(s): Rose, David P;Vona-Davis, Linda;
Institution: Department of Surgery, Mary Babb Randolph Cancer Center, West Virginia University Robert C. Byrd Health Sciences Center, Morgantown, WV 26506, USA.
Shortcut link to this study:
Obesity has a complex relationship to breast cancer risk that differs in premenopausal and postmenopausal women. Before the menopause, the level of adiposity is inversely related to risk, indicative of a protective effect, whereas in postmenopausal women, particularly the elderly, the association is a positive one, consistent with obesity being a risk factor. The importance of high estrogen production in adipose tissue, with consequent elevation of circulating biologically available estradiol, in the promotional effect of obesity on postmenopausal breast carcinogenesis is well established; the resulting tumors express both estrogen and progesterone receptors. The mechanism(s) for the protective effect in premenopausal women is less well understood, but the breast cancers that do develop in the presence of obesity are most often estrogen and progesterone receptor negative, consistent with the selection of non-estrogen-dependent tumor cells which are dependent on growth factors such as insulin, insulin-like growth factor-I and some adipokines. The influence of menopausal status on the relationships between adiposity and breast cancer appears to be modified within each category by age; the protective effect before the menopause may be limited to younger women (<35 years), and the adverse effect was found to apply specifically to older postmenopausal women. Although randomized trials of weight reduction for postmenopausal breast cancer prevention have not been performed, observational studies suggested that risk reduction does occur; in addition, other health benefits of weight control need to be considered regardless of menopausal status.
PMID: 20181446

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