|
|
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result sql = Tolerability and efficacy of a novel formulation in the treatment of melasma.
Tolerability and efficacy of a novel formulation in the treatment of melasma.char = <;code = 60
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char = e;code = 101
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char = e;code = 101
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char = t;code = 116
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = p;code = 112
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char = c;code = 99
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char = a;code = 97
char = n;code = 110
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char = a;code = 97
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char = ;code = 32
char = e;code = 101
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char = l;code = 108
char = u;code = 117
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char = t;code = 116
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char = o;code = 111
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char = v;code = 118
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char = m;code = 109
char = e;code = 101
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char = t;code = 116
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char = n;code = 110
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char = l;code = 108
char = l;code = 108
char = ;code = 32
char = p;code = 112
char = a;code = 97
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char = i;code = 105
char = e;code = 101
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char = t;code = 116
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char = b;code = 98
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char = <;code = 60
char = b;code = 98
char = r;code = 114
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char = l;code = 108
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char = f;code = 102
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char = b;code = 98
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char = C;code = 67
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char = S;code = 83
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char = O;code = 79
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char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = A;code = 65
char = ;code = 32
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = m;code = 109
char = ;code = 32
char = c;code = 99
char = o;code = 111
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char = t;code = 116
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char = i;code = 105
char = n;code = 110
char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = d;code = 100
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = a;code = 97
char = l;code = 108
char = u;code = 117
char = r;code = 114
char = o;code = 111
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = m;code = 109
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = p;code = 112
char = r;code = 114
char = o;code = 111
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char = e;code = 101
char = m;code = 109
char = e;code = 101
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char = n;code = 110
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char = p;code = 112
char = a;code = 97
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char = i;code = 105
char = e;code = 101
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char = t;code = 116
char = s;code = 115
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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result sql = BACKGROUND : Topical agents containing mixtures of hydroquinone and glycolic acid often cause irritation in patients with melasma.
OBJECTIVE : The authors assessed the safety and efficacy of a new cream containing hydroquinone (HQ), glycolic acid, and hyaluronic acid for epidermal melasma.
METHODS : Fifteen Latin American women with bilateral epidermal melasma underwent twice-daily full face application with the study cream for 12 weeks. A moisturizer was added if irritation developed.
RESULTS : Mexameter data revealed that 14 of 15 patients (93%) improved, and there was a significant decrease in MASI (melasma area and severity index) scores of 64% over the course of the study. Fifty-three percent of the patients required a moisturizer after eight weeks of treatment. The majority of adverse events were mild. Patient and physician global evaluation showed moderate, obvious or very marked improvement in all patients.
LIMITATIONS : Open, uncontrolled trial in a small number of patients.
CONCLUSION : A cream containing hydroquinone, glycolic acid and hyaluronic acid demonstrates improvement in patients with melasma.
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char = f;code = 102
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char = f;code = 102
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result sql = Tolerability and efficacy of a novel formulation in the treatment of melasma.
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char = ;code = 32
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char = 4;code = 52
char = %;code = 37
char = ;code = 32
char = o;code = 111
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
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char = s;code = 115
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
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char = u;code = 117
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char = a;code = 97
char = t;code = 116
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = j;code = 106
char = o;code = 111
char = r;code = 114
char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = o;code = 111
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char = ;code = 32
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char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = m;code = 109
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char = l;code = 108
char = d;code = 100
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char = ;code = 32
char = P;code = 80
char = a;code = 97
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char = i;code = 105
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char = t;code = 116
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char = n;code = 110
char = d;code = 100
char = ;code = 32
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char = h;code = 104
char = y;code = 121
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char = c;code = 99
char = i;code = 105
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = g;code = 103
char = l;code = 108
char = o;code = 111
char = b;code = 98
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = e;code = 101
char = v;code = 118
char = a;code = 97
char = l;code = 108
char = u;code = 117
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = h;code = 104
char = o;code = 111
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = d;code = 100
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char = ;code = 32
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char = v;code = 118
char = i;code = 105
char = o;code = 111
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char = s;code = 115
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char = o;code = 111
char = r;code = 114
char = ;code = 32
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = y;code = 121
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char = a;code = 97
char = r;code = 114
char = k;code = 107
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = v;code = 118
char = e;code = 101
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = L;code = 76
char = I;code = 73
char = M;code = 77
char = I;code = 73
char = T;code = 84
char = A;code = 65
char = T;code = 84
char = I;code = 73
char = O;code = 79
char = N;code = 78
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = O;code = 79
char = p;code = 112
char = e;code = 101
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = u;code = 117
char = n;code = 110
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = l;code = 108
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = r;code = 114
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char = l;code = 108
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = ;code = 32
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char = m;code = 109
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char = ;code = 32
char = p;code = 112
char = a;code = 97
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char = s;code = 115
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char = b;code = 98
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char = <;code = 60
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char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
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char = C;code = 67
char = O;code = 79
char = N;code = 78
char = C;code = 67
char = L;code = 76
char = U;code = 85
char = S;code = 83
char = I;code = 73
char = O;code = 79
char = N;code = 78
char = ;code = 32
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char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = A;code = 65
char = ;code = 32
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char = r;code = 114
char = e;code = 101
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char = ;code = 32
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char = o;code = 111
char = n;code = 110
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char = i;code = 105
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char = o;code = 111
char = n;code = 110
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char = y;code = 121
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char = o;code = 111
char = l;code = 108
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = a;code = 97
char = l;code = 108
char = u;code = 117
char = r;code = 114
char = o;code = 111
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = m;code = 109
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = v;code = 118
char = e;code = 101
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = l;code = 108
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char = m;code = 109
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result sql = BACKGROUND : Topical agents containing mixtures of hydroquinone and glycolic acid often cause irritation in patients with melasma.
OBJECTIVE : The authors assessed the safety and efficacy of a new cream containing hydroquinone (HQ), glycolic acid, and hyaluronic acid for epidermal melasma.
METHODS : Fifteen Latin American women with bilateral epidermal melasma underwent twice-daily full face application with the study cream for 12 weeks. A moisturizer was added if irritation developed.
RESULTS : Mexameter data revealed that 14 of 15 patients (93%) improved, and there was a significant decrease in MASI (melasma area and severity index) scores of 64% over the course of the study. Fifty-three percent of the patients required a moisturizer after eight weeks of treatment. The majority of adverse events were mild. Patient and physician global evaluation showed moderate, obvious or very marked improvement in all patients.
LIMITATIONS : Open, uncontrolled trial in a small number of patients.
CONCLUSION : A cream containing hydroquinone, glycolic acid and hyaluronic acid demonstrates improvement in patients with melasma.
Publication: J Drugs Dermatol 2010 Mar ;9(3)::215-8.
Publication Date: 2010 Mar
Study Author(s): Guevara, Ian L;Werlinger, Kelly D;Pandya, Amit G;
Institution: University of Texas Southwestern Medical Center, Dallas, TX, USA.
Shortcut link to this study:
Publication Date: 2010 Mar
Study Author(s): Guevara, Ian L;Werlinger, Kelly D;Pandya, Amit G;
Institution: University of Texas Southwestern Medical Center, Dallas, TX, USA.
Shortcut link to this study:
BACKGROUND : Topical agents containing mixtures of hydroquinone and glycolic acid often cause irritation in patients with melasma.
OBJECTIVE : The authors assessed the safety and efficacy of a new cream containing hydroquinone (HQ), glycolic acid, and hyaluronic acid for epidermal melasma.
METHODS : Fifteen Latin American women with bilateral epidermal melasma underwent twice-daily full face application with the study cream for 12 weeks. A moisturizer was added if irritation developed.
RESULTS : Mexameter data revealed that 14 of 15 patients (93%) improved, and there was a significant decrease in MASI (melasma area and severity index) scores of 64% over the course of the study. Fifty-three percent of the patients required a moisturizer after eight weeks of treatment. The majority of adverse events were mild. Patient and physician global evaluation showed moderate, obvious or very marked improvement in all patients.
LIMITATIONS : Open, uncontrolled trial in a small number of patients.
CONCLUSION : A cream containing hydroquinone, glycolic acid and hyaluronic acid demonstrates improvement in patients with melasma.
OBJECTIVE : The authors assessed the safety and efficacy of a new cream containing hydroquinone (HQ), glycolic acid, and hyaluronic acid for epidermal melasma.
METHODS : Fifteen Latin American women with bilateral epidermal melasma underwent twice-daily full face application with the study cream for 12 weeks. A moisturizer was added if irritation developed.
RESULTS : Mexameter data revealed that 14 of 15 patients (93%) improved, and there was a significant decrease in MASI (melasma area and severity index) scores of 64% over the course of the study. Fifty-three percent of the patients required a moisturizer after eight weeks of treatment. The majority of adverse events were mild. Patient and physician global evaluation showed moderate, obvious or very marked improvement in all patients.
LIMITATIONS : Open, uncontrolled trial in a small number of patients.
CONCLUSION : A cream containing hydroquinone, glycolic acid and hyaluronic acid demonstrates improvement in patients with melasma.
PMID: 20232581
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