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result sql = Anti-inflammatory effect of crude extract and isolated compounds from Baccharis illinita DC in acute skin inflammation.
Anti-inflammatory effect of crude extract and isolated compounds from Baccharis illinita DC in acute skin inflammation.
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char = C;code = 67
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char = O;code = 79
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char = e;code = 101
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char = n;code = 110
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char = m;code = 109
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char = a;code = 97
char = l;code = 108
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char = f;code = 102
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char = c;code = 99
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char = ;code = 32
char = d;code = 100
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char = s;code = 115
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result sql = UNLABELLED : ETHNOPHARMACOLOGYCAL RELEVANCE: The tea from the leaves of Baccharis illinita DC (Asteraceae family) is commonly used by the population as anti-inflammatory (including topically), protective gastric and anti-infectious. However, no studies have been done with this species to confirm its topical anti-inflammatory action.

AIM : This study evaluated he topical effects of crude extract of leaves (CE) and its active constituents in 12-O-tetradecanoylphorbol acetate (TPA)-induced ear oedema.

METHODOLOGY : CE and compounds effects were tested in commonly used models of TPA-, arachidonic acid (AA)- and capsaicin-ear oedema. Polymorphonuclear (PMN) cell migration was evaluated by mieloperoxidase and analyzed histologically.

RESULTS : CE (0.1-1 mg/ear) caused a dose-related inhibition of TPA-induced ear oedema and PMN influx similarly to that produced by topical application of the steroidal anti-inflammatory drug dexamethasone. The active constituents of the AcOEt fraction kaurenoic acid, alpha-spinasterol, oleanolic acid and baurenol also inhibited TPA-induced ear edema. Histological analysis of the ear of CE-treated animals confirmed the reduction of edema and of PMN infiltration. Both CE and the nosteroidal anti-inflammatory drug indomethacin inhibited the AA-induced ear oedema, but did not change capsaicin-induced oedema.

CONCLUSION : These results indicate that the CE and the active constituents have a topical anti-inflammatory effect and the possible mechanisms for the pharmacological effects are discussed.

Publication: J Ethnopharmacol 2010 Jul 20 ;130(2)::262-6. :doi: 10.1016/j.jep.2010.05.001.
Publication Date: 2010 Jul 20
Study Author(s): Boller, Shirley;Soldi, Cristian;Marques, Maria C A;Santos, Elide P;Cabrini, Daniela A;Pizzolatti, Moacir G;Zampronio, Aleksander R;Otuki, Michel F;
Institution: Department of Pharmacology, Federal University Federal of Paraná, Curitiba, PR, Brazil.
Shortcut link to this study:
UNLABELLED : ETHNOPHARMACOLOGYCAL RELEVANCE: The tea from the leaves of Baccharis illinita DC (Asteraceae family) is commonly used by the population as anti-inflammatory (including topically), protective gastric and anti-infectious. However, no studies have been done with this species to confirm its topical anti-inflammatory action.

AIM : This study evaluated he topical effects of crude extract of leaves (CE) and its active constituents in 12-O-tetradecanoylphorbol acetate (TPA)-induced ear oedema.

METHODOLOGY : CE and compounds effects were tested in commonly used models of TPA-, arachidonic acid (AA)- and capsaicin-ear oedema. Polymorphonuclear (PMN) cell migration was evaluated by mieloperoxidase and analyzed histologically.

RESULTS : CE (0.1-1 mg/ear) caused a dose-related inhibition of TPA-induced ear oedema and PMN influx similarly to that produced by topical application of the steroidal anti-inflammatory drug dexamethasone. The active constituents of the AcOEt fraction kaurenoic acid, alpha-spinasterol, oleanolic acid and baurenol also inhibited TPA-induced ear edema. Histological analysis of the ear of CE-treated animals confirmed the reduction of edema and of PMN infiltration. Both CE and the nosteroidal anti-inflammatory drug indomethacin inhibited the AA-induced ear oedema, but did not change capsaicin-induced oedema.

CONCLUSION : These results indicate that the CE and the active constituents have a topical anti-inflammatory effect and the possible mechanisms for the pharmacological effects are discussed.
PMID: 20452414

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