|
|
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result sql = Upregulation of urotensin II receptor in preeclampsia causes in vitro placental release of soluble vascular endothelial growth factor receptor 1 in hypoxia.
Upregulation of urotensin II receptor in preeclampsia causes in vitro placental release of soluble vascular endothelial growth factor receptor 1 in hypoxia.char = P;code = 80
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result sql = Preeclampsia is a hypertensive disorder of pregnancy caused by abnormal placental function, partly because of chronic hypoxia at the utero-placental junction. The increase in levels of soluble vascular endothelial growth factor receptor 1, an antiangiogenic agent known to inhibit placental vascularization, is an important cellular factor implicated in the onset of preeclampsia. We investigated the ligand urotensin II (U-II), a potent endogenous vasoconstrictor and proangiogenic agent, for which levels have been reported to increase in patients with preeclampsia. We hypothesized that an increased sensitivity to U-II in preeclampsia might be achieved by upregulation of placental U-II receptors. We further investigated the role of U-II receptor stimulation on soluble vascular endothelial growth factor receptor 1 release in placental explants from diseased and normal patients. Immunohistochemistry, real-time PCR, and Western blotting analysis revealed that U-II receptor expression was significantly upregulated in preeclampsia placentas compared with controls (P<0.01). Cellular models of syncytiotrophoblast and vascular endothelial cells subjected to hypoxic conditions revealed an increase in U-II receptor levels in the syncytiotrophoblast model. This induction is regulated by the transcriptional activator hypoxia-inducible factor 1alpha U-II : treatment is associated with increased secretion of soluble vascular endothelial growth factor receptor 1 only in preeclamptic placental explants under hypoxia but not in control conditions. Interestingly, normal placental explants did not respond to U-II stimulation.
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char = I;code = 73
char = I;code = 73
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char = r;code = 114
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char = c;code = 99
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char = e;code = 101
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char = r;code = 114
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char = l;code = 108
char = e;code = 101
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char = e;code = 101
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char = f;code = 102
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char = s;code = 115
char = o;code = 111
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char = l;code = 108
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char = n;code = 110
char = d;code = 100
char = o;code = 111
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char = i;code = 105
char = a;code = 97
char = l;code = 108
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char = g;code = 103
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char = r;code = 114
char = e;code = 101
char = c;code = 99
char = e;code = 101
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char = o;code = 111
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char = 1;code = 49
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char = y;code = 121
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char = o;code = 111
char = x;code = 120
char = i;code = 105
char = a;code = 97
char = .;code = 46
result sql = Upregulation of urotensin II receptor in preeclampsia causes in vitro placental release of soluble vascular endothelial growth factor receptor 1 in hypoxia.
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char = e;code = 101
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char = ;code = 32
char = h;code = 104
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char = e;code = 101
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char = g;code = 103
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char = n;code = 110
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char = c;code = 99
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char = u;code = 117
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char = h;code = 104
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char = u;code = 117
char = t;code = 116
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char = l;code = 108
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char = j;code = 106
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char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = i;code = 105
char = n;code = 110
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char = r;code = 114
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char = l;code = 108
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char = e;code = 101
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char = f;code = 102
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char = c;code = 99
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char = v;code = 118
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char = a;code = 97
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char = i;code = 105
char = m;code = 109
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char = o;code = 111
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char = t;code = 116
char = a;code = 97
char = n;code = 110
char = t;code = 116
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char = c;code = 99
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char = l;code = 108
char = u;code = 117
char = l;code = 108
char = a;code = 97
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char = f;code = 102
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char = o;code = 111
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char = i;code = 105
char = m;code = 109
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char = l;code = 108
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char = e;code = 101
char = d;code = 100
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char = e;code = 101
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char = a;code = 97
char = .;code = 46
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char = W;code = 87
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char = n;code = 110
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char = I;code = 73
char = I;code = 73
char = ;code = 32
char = (;code = 40
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char = I;code = 73
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result sql = Preeclampsia is a hypertensive disorder of pregnancy caused by abnormal placental function, partly because of chronic hypoxia at the utero-placental junction. The increase in levels of soluble vascular endothelial growth factor receptor 1, an antiangiogenic agent known to inhibit placental vascularization, is an important cellular factor implicated in the onset of preeclampsia. We investigated the ligand urotensin II (U-II), a potent endogenous vasoconstrictor and proangiogenic agent, for which levels have been reported to increase in patients with preeclampsia. We hypothesized that an increased sensitivity to U-II in preeclampsia might be achieved by upregulation of placental U-II receptors. We further investigated the role of U-II receptor stimulation on soluble vascular endothelial growth factor receptor 1 release in placental explants from diseased and normal patients. Immunohistochemistry, real-time PCR, and Western blotting analysis revealed that U-II receptor expression was significantly upregulated in preeclampsia placentas compared with controls (P<0.01). Cellular models of syncytiotrophoblast and vascular endothelial cells subjected to hypoxic conditions revealed an increase in U-II receptor levels in the syncytiotrophoblast model. This induction is regulated by the transcriptional activator hypoxia-inducible factor 1alpha U-II : treatment is associated with increased secretion of soluble vascular endothelial growth factor receptor 1 only in preeclamptic placental explants under hypoxia but not in control conditions. Interestingly, normal placental explants did not respond to U-II stimulation.
Publication: Hypertension 2010 Jul ;56(1)::172-8. :doi: 10.1161/HYPERTENSIONAHA.110.152074.
Publication Date: 2010 Jul
Study Author(s): Gould, Phillip S;Gu, Mei;Liao, Jianqin;Ahmad, Shakil;Cudmore, Melissa J;Ahmed, Asif;Vatish, Manu;
Institution: Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, United Kingdom.
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Publication Date: 2010 Jul
Study Author(s): Gould, Phillip S;Gu, Mei;Liao, Jianqin;Ahmad, Shakil;Cudmore, Melissa J;Ahmed, Asif;Vatish, Manu;
Institution: Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry, United Kingdom.
Shortcut link to this study:
Preeclampsia is a hypertensive disorder of pregnancy caused by abnormal placental function, partly because of chronic hypoxia at the utero-placental junction. The increase in levels of soluble vascular endothelial growth factor receptor 1, an antiangiogenic agent known to inhibit placental vascularization, is an important cellular factor implicated in the onset of preeclampsia. We investigated the ligand urotensin II (U-II), a potent endogenous vasoconstrictor and proangiogenic agent, for which levels have been reported to increase in patients with preeclampsia. We hypothesized that an increased sensitivity to U-II in preeclampsia might be achieved by upregulation of placental U-II receptors. We further investigated the role of U-II receptor stimulation on soluble vascular endothelial growth factor receptor 1 release in placental explants from diseased and normal patients. Immunohistochemistry, real-time PCR, and Western blotting analysis revealed that U-II receptor expression was significantly upregulated in preeclampsia placentas compared with controls (P<0.01). Cellular models of syncytiotrophoblast and vascular endothelial cells subjected to hypoxic conditions revealed an increase in U-II receptor levels in the syncytiotrophoblast model. This induction is regulated by the transcriptional activator hypoxia-inducible factor 1alpha U-II : treatment is associated with increased secretion of soluble vascular endothelial growth factor receptor 1 only in preeclamptic placental explants under hypoxia but not in control conditions. Interestingly, normal placental explants did not respond to U-II stimulation.
PMID: 20479331
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