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result sql = S-aryltriazole acyclonucleosides: synthesis and biological evaluation against hepatitis C virus.
S-aryltriazole acyclonucleosides: synthesis and biological evaluation against hepatitis C virus.
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result sql = Novel S-aryltriazole acyclonucleosides were designed as structural analogs based on the previously identified antiviral aryltriazole acyclonucleosides in our laboratories. These S-aryltriazole nucleosides were synthesized in excellent yields via S(N)Ar-mediated S-arylation, followed by subsequent ammonolysis. X-ray structural analysis revealed special structural feature brought by the S-linkage, which may represent an unfavorable factor contributing to the lack of anti-HCV activity for this family of triazole nucleosides.

Publication: Bioorg. Med. Chem. Lett. 2010 Jun 15 ;20(12)::3610-3. :doi: 10.1016/j.bmcl.2010.04.115.
Publication Date: 2010 Jun 15
Study Author(s): Liu, Yang;Xia, Yi;Li, Wei;Cong, Mei;Maggiani, Alain;Leyssen, Pieter;Qu, Fanqi;Neyts, Johan;Peng, Ling;
Institution: State Key Laboratory of Virology, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, PR China.
Shortcut link to this study:
Novel S-aryltriazole acyclonucleosides were designed as structural analogs based on the previously identified antiviral aryltriazole acyclonucleosides in our laboratories. These S-aryltriazole nucleosides were synthesized in excellent yields via S(N)Ar-mediated S-arylation, followed by subsequent ammonolysis. X-ray structural analysis revealed special structural feature brought by the S-linkage, which may represent an unfavorable factor contributing to the lack of anti-HCV activity for this family of triazole nucleosides.
PMID: 20483607

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