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result sql = Type I interferon signaling contributes to chronic inflammation in a murine model of silicosis.
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result sql = Lung disorders induced by inhaled inorganic particles such as crystalline silica are characterized by chronic inflammation and pulmonary fibrosis. Here, we demonstrate the importance of type I interferon (IFN) in the development of crystalline silica-induced lung inflammation in mice, revealing that viruses and inorganic particles share similar signaling pathways. We found that instillation of silica is followed by the upregulation of IFN-beta and IRF-7 and that granulocytes (GR1(+)) and macrophages/dendritic cells (CD11c(+)) are major producers of type I IFN in response to silica. Two months after silica administration, both IFNAR- and IRF-7-deficient mice produced significantly less pulmonary inflammation and chemokines (KC and CCL2) than competent mice but developed similar lung fibrosis. Our data indicate that type I IFN contributes to the chronic lung inflammation that accompanies silica exposure in mice. Type I IFN is, however, dispensable in the development of silica-induced acute lung inflammation and pulmonary fibrosis.
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result sql = Type I interferon signaling contributes to chronic inflammation in a murine model of silicosis.
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result sql = Lung disorders induced by inhaled inorganic particles such as crystalline silica are characterized by chronic inflammation and pulmonary fibrosis. Here, we demonstrate the importance of type I interferon (IFN) in the development of crystalline silica-induced lung inflammation in mice, revealing that viruses and inorganic particles share similar signaling pathways. We found that instillation of silica is followed by the upregulation of IFN-beta and IRF-7 and that granulocytes (GR1(+)) and macrophages/dendritic cells (CD11c(+)) are major producers of type I IFN in response to silica. Two months after silica administration, both IFNAR- and IRF-7-deficient mice produced significantly less pulmonary inflammation and chemokines (KC and CCL2) than competent mice but developed similar lung fibrosis. Our data indicate that type I IFN contributes to the chronic lung inflammation that accompanies silica exposure in mice. Type I IFN is, however, dispensable in the development of silica-induced acute lung inflammation and pulmonary fibrosis.
Publication: Toxicol. Sci. 2010 Aug ;116(2)::682-92. :doi: 10.1093/toxsci/kfq158.
Publication Date: 2010 Aug
Study Author(s): Giordano, Giulia;van den Brûle, Sybille;Lo Re, Sandra;Triqueneaux, Perrine;Uwambayinema, Francine;Yakoub, Yousof;Couillin, Isabelle;Ryffel, Bernhard;Michiels, Thomas;Renauld, Jean-Christophe;Lison, Dominique;Huaux, François;
Institution: Louvain Centre for Toxicology and Applied Pharmacology, Université catholique de Louvain, 1200 Brussels, Belgium.
Shortcut link to this study:
Publication Date: 2010 Aug
Study Author(s): Giordano, Giulia;van den Brûle, Sybille;Lo Re, Sandra;Triqueneaux, Perrine;Uwambayinema, Francine;Yakoub, Yousof;Couillin, Isabelle;Ryffel, Bernhard;Michiels, Thomas;Renauld, Jean-Christophe;Lison, Dominique;Huaux, François;
Institution: Louvain Centre for Toxicology and Applied Pharmacology, Université catholique de Louvain, 1200 Brussels, Belgium.
Shortcut link to this study:
Lung disorders induced by inhaled inorganic particles such as crystalline silica are characterized by chronic inflammation and pulmonary fibrosis. Here, we demonstrate the importance of type I interferon (IFN) in the development of crystalline silica-induced lung inflammation in mice, revealing that viruses and inorganic particles share similar signaling pathways. We found that instillation of silica is followed by the upregulation of IFN-beta and IRF-7 and that granulocytes (GR1(+)) and macrophages/dendritic cells (CD11c(+)) are major producers of type I IFN in response to silica. Two months after silica administration, both IFNAR- and IRF-7-deficient mice produced significantly less pulmonary inflammation and chemokines (KC and CCL2) than competent mice but developed similar lung fibrosis. Our data indicate that type I IFN contributes to the chronic lung inflammation that accompanies silica exposure in mice. Type I IFN is, however, dispensable in the development of silica-induced acute lung inflammation and pulmonary fibrosis.
PMID: 20513754
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