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char = 2;code = 50
char = A;code = 65
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char = d;code = 100
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char = m;code = 109
char = o;code = 111
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char = t;code = 116
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char = o;code = 111
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char = d;code = 100
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char = o;code = 111
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char = ;code = 32
char = n;code = 110
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char = v;code = 118
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char = f;code = 102
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char = t;code = 116
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = T;code = 84
char = L;code = 76
char = R;code = 82
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = o;code = 111
char = n;code = 110
char = i;code = 105
char = s;code = 115
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char = ';code = 39
char = s;code = 115
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char = a;code = 97
char = n;code = 110
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char = t;code = 116
char = u;code = 117
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char = o;code = 111
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char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = ;code = 32
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char = d;code = 100
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char = n;code = 110
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char = t;code = 116
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result sql = The aim of the current study was to evaluate the influence of chemotherapeutic drugs on immunotherapy with Imidazoquinoline Toll-like Receptor (TLR) agonists in cancer. First, the previously described antitumor efficacy of TLR agonists [i.e. a TLR7 agonist (852A) and a dual TLR7/8 agonist (3M-011)] was confirmed in additional cancer models, and second the therapeutic potential of TLR agonists in combination with cyclophosphamide was investigated. The antitumor potential was evaluated against a panel of syngeneic tumor models; namely B16-F10 melanoma, M3 melanoma and MC-26 colon carcinoma. Systemic administration of either 3M-011 or 852A in these various syngeneic models induced significant antitumor activity as evidenced by delays in tumor growth curves. Combination of cyclophosphamide with either 3M-011 or 852A demonstrated that cyclophosphamide does not negatively interfere with the TLR agonist's antitumor effects, but may, depending on the dosing schedule, to actually potentiate the effect. These findings suggest that the immunomodulatory TLR agonists may be used in combination with cytotoxic agents in the treatment of cancer.
char = o;code = 111
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char = i;code = 105
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = -;code = 45
char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = i;code = 105
char = m;code = 109
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char = d;code = 100
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char = z;code = 122
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char = y;code = 121
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char = d;code = 100
char = e;code = 101
char = .;code = 46
result sql = Potentiation of the anti-tumor effects of imidazoquinoline immune response modifiers by cyclophosphamide.
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char = r;code = 114
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result sql = The aim of the current study was to evaluate the influence of chemotherapeutic drugs on immunotherapy with Imidazoquinoline Toll-like Receptor (TLR) agonists in cancer. First, the previously described antitumor efficacy of TLR agonists [i.e. a TLR7 agonist (852A) and a dual TLR7/8 agonist (3M-011)] was confirmed in additional cancer models, and second the therapeutic potential of TLR agonists in combination with cyclophosphamide was investigated. The antitumor potential was evaluated against a panel of syngeneic tumor models; namely B16-F10 melanoma, M3 melanoma and MC-26 colon carcinoma. Systemic administration of either 3M-011 or 852A in these various syngeneic models induced significant antitumor activity as evidenced by delays in tumor growth curves. Combination of cyclophosphamide with either 3M-011 or 852A demonstrated that cyclophosphamide does not negatively interfere with the TLR agonist's antitumor effects, but may, depending on the dosing schedule, to actually potentiate the effect. These findings suggest that the immunomodulatory TLR agonists may be used in combination with cytotoxic agents in the treatment of cancer.
Publication: Cancer Biol. Ther. 2010 Jul 15 ;10(2)::155-65.
Publication Date: 2010 Jul 15
Study Author(s): Dumitru, Calin D;Antonysamy, Mary A;Tomai, Mark A;Lipson, Kenneth E;
Institution: Merck Research Laboratories, Rahway, NJ, USA. [email protected]
Shortcut link to this study:
Publication Date: 2010 Jul 15
Study Author(s): Dumitru, Calin D;Antonysamy, Mary A;Tomai, Mark A;Lipson, Kenneth E;
Institution: Merck Research Laboratories, Rahway, NJ, USA. [email protected]
Shortcut link to this study:
The aim of the current study was to evaluate the influence of chemotherapeutic drugs on immunotherapy with Imidazoquinoline Toll-like Receptor (TLR) agonists in cancer. First, the previously described antitumor efficacy of TLR agonists [i.e. a TLR7 agonist (852A) and a dual TLR7/8 agonist (3M-011)] was confirmed in additional cancer models, and second the therapeutic potential of TLR agonists in combination with cyclophosphamide was investigated. The antitumor potential was evaluated against a panel of syngeneic tumor models; namely B16-F10 melanoma, M3 melanoma and MC-26 colon carcinoma. Systemic administration of either 3M-011 or 852A in these various syngeneic models induced significant antitumor activity as evidenced by delays in tumor growth curves. Combination of cyclophosphamide with either 3M-011 or 852A demonstrated that cyclophosphamide does not negatively interfere with the TLR agonist's antitumor effects, but may, depending on the dosing schedule, to actually potentiate the effect. These findings suggest that the immunomodulatory TLR agonists may be used in combination with cytotoxic agents in the treatment of cancer.
PMID: 20519933
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