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result sql = T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis.
T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis.
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result sql = A series of spiro-azetidines and azetidinones has been evaluated as novel blockers of the T-type calcium channel (Ca(V)3.2) which is a new therapeutic target for the potential treatment of both inflammatory and neuropathic pain. Confirmation and optimization of the potency, selectivity and DMPK properties of leads will be described.

Publication: Bioorg. Med. Chem. Lett. 2010 Aug 1 ;20(15)::4602-6. :doi: 10.1016/j.bmcl.2010.06.012.
Publication Date: 2010 Aug 1
Study Author(s): Smith, Elizabeth M;Sorota, Steve;Kim, Hyunjin M;McKittrick, Brian A;Nechuta, Terry L;Bennett, Chad;Knutson, Chad;Burnett, Duane A;Kieselgof, Jane;Tan, Zheng;Rindgen, Diane;Bridal, Terry;Zhou, Xiaoping;Jia, Yu-Ping;Dong, Zoe;Mullins, Debbie;Zhang, Xiaoping;Priestley, Tony;Correll, Craig C;Tulshian, Deen;Czarniecki, Michael;Greenlee, William J;
Institution: Department of Medicinal Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, USA. [email protected]
Shortcut link to this study:
A series of spiro-azetidines and azetidinones has been evaluated as novel blockers of the T-type calcium channel (Ca(V)3.2) which is a new therapeutic target for the potential treatment of both inflammatory and neuropathic pain. Confirmation and optimization of the potency, selectivity and DMPK properties of leads will be described.
PMID: 20580233

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