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char = o;code = 111
char = p;code = 112
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char = c;code = 99
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char = n;code = 110
char = d;code = 100
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = x;code = 120
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = o;code = 111
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = -;code = 45
char = 9;code = 57
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = a;code = 97
char = n;code = 110
char = g;code = 103
char = i;code = 105
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = b;code = 98
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = .;code = 46
result sql = Sesamin inhibits macrophage-induced vascular endothelial growth factor and matrix metalloproteinase-9 expression and proangiogenic activity in breast cancer cells.

Sesamin inhibits macrophage-induced vascular endothelial growth factor and matrix metalloproteinase-9 expression and proangiogenic activity in breast cancer cells.

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char = ;code = 32
char = M;code = 77
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char = l;code = 108
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char = p;code = 112
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char = s;code = 115
char = s;code = 115
char = e;code = 101
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char = s;code = 115
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char = s;code = 115
char = a;code = 97
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char = V;code = 86
char = a;code = 97
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char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
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char = e;code = 101
char = n;code = 110
char = d;code = 100
char = o;code = 111
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char = i;code = 105
char = a;code = 97
char = l;code = 108
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char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
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char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
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char = r;code = 114
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char = V;code = 86
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char = G;code = 71
char = F;code = 70
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char = d;code = 100
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char = a;code = 97
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char = r;code = 114
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char = x;code = 120
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char = a;code = 97
char = l;code = 108
char = l;code = 108
char = o;code = 111
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = M;code = 77
char = M;code = 77
char = P;code = 80
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char = p;code = 112
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char = a;code = 97
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char = e;code = 101
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char = i;code = 105
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char = o;code = 111
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char = c;code = 99
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char = l;code = 108
char = ;code = 32
char = l;code = 108
char = i;code = 105
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char = e;code = 101
char = s;code = 115
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char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = o;code = 111
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char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
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char = b;code = 98
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char = s;code = 115
char = e;code = 101
char = s;code = 115
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = .;code = 46
char = ;code = 32
char = N;code = 78
char = u;code = 117
char = c;code = 99
char = l;code = 108
char = e;code = 101
char = a;code = 97
char = r;code = 114
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char = l;code = 108
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = H;code = 72
char = I;code = 73
char = F;code = 70
char = -;code = 45
char = 1;code = 49
char = &;code = 38
char = #;code = 35
char = 9;code = 57
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char = 5;code = 53
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = N;code = 78
char = F;code = 70
char = -;code = 45
char = &;code = 38
char = #;code = 35
char = 9;code = 57
char = 5;code = 53
char = 4;code = 52
char = ;;code = 59
char = B;code = 66
char = ,;code = 44
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char = i;code = 105
char = m;code = 109
char = p;code = 112
char = o;code = 111
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char = t;code = 116
char = a;code = 97
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char = t;code = 116
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char = t;code = 116
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = s;code = 115
char = c;code = 99
char = r;code = 114
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char = p;code = 112
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
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char = r;code = 114
char = s;code = 115
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = V;code = 86
char = E;code = 69
char = G;code = 71
char = F;code = 70
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = M;code = 77
char = M;code = 77
char = P;code = 80
char = -;code = 45
char = 9;code = 57
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char = e;code = 101
char = x;code = 120
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char = r;code = 114
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char = s;code = 115
char = s;code = 115
char = i;code = 105
char = o;code = 111
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char = ,;code = 44
char = ;code = 32
char = r;code = 114
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char = s;code = 115
char = p;code = 112
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char = c;code = 99
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char = e;code = 101
char = l;code = 108
char = y;code = 121
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char = ;code = 32
char = w;code = 119
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char = r;code = 114
char = e;code = 101
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char = u;code = 117
char = s;code = 115
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char = u;code = 117
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char = s;code = 115
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char = V;code = 86
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char = G;code = 71
char = F;code = 70
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char = :;code = 58
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char = <;code = 60
char = /;code = 47
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char = o;code = 111
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char = a;code = 97
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char = s;code = 115
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char = E;code = 69
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char = K;code = 75
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char = J;code = 74
char = N;code = 78
char = K;code = 75
char = ,;code = 44
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char = d;code = 100
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char = N;code = 78
char = F;code = 70
char = -;code = 45
char = &;code = 38
char = #;code = 35
char = 9;code = 57
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char = a;code = 97
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char = T;code = 84
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char = a;code = 97
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char = M;code = 77
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char = K;code = 75
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char = a;code = 97
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char = a;code = 97
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char = u;code = 117
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char = d;code = 100
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char = M;code = 77
char = M;code = 77
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char = -;code = 45
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char = e;code = 101
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char = e;code = 101
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char = s;code = 115
char = i;code = 105
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char = e;code = 101
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char = e;code = 101
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char = a;code = 97
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char = h;code = 104
char = w;code = 119
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char = 6;code = 54
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char = V;code = 86
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char = G;code = 71
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char = M;code = 77
char = P;code = 80
char = -;code = 45
char = 9;code = 57
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char = m;code = 109
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char = N;code = 78
char = A;code = 65
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char = e;code = 101
char = x;code = 120
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char = F;code = 70
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char = S;code = 83
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char = a;code = 97
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char = i;code = 105
char = n;code = 110
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char = d;code = 100
char = ;code = 32
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char = M;code = 77
char = P;code = 80
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char = ;code = 32
char = I;code = 73
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result sql = Sesamin is a sesame component with antihypertensive and antioxidative activities and has recently aroused much interest in studying its potential anticancer application. Macrophage is one of the infiltrating inflammatory cells in solid tumor and may promote tumor progression via enhancement of tumor angiogenesis. In this study, we investigated whether sesamin inhibited macrophage-enhanced proangiogenic activity of breast cancer cell lines MCF-7 and MDA-MB-231. Using vascular endothelial cell capillary tube and network formation assays, both breast cancer cell lines exhibited elevated proangiogenic activities after coculture with macrophages or pretreatment with macrophage-conditioned medium. This elevation of proangiogenic activity was drastically suppressed by sesamin. Vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) induced by macrophages in both cell lines were also inhibited by sesamin. Nuclear levels of HIF-1α and NF-κB, important transcription factors for VEGF and MMP-9 expression, respectively, were obviously reduced by sesamin VEGF : induction by macrophage in MCF-7 cells was shown to be via ERK, JNK, phosphatidylinositol 3-kinase, and NF-κB-mediated pathways. These signaling molecules and additional p38(MAPK) were also involved in macrophage-induced MMP-9 expression. Despite such diverse pathways were induced by macrophage, only Akt and p38(MAPK) activities were potently inhibited by sesamin. Expression of interleukin (IL)-6, IL-8, and tumor necrosis factor-α were substantially increased and involved in macrophage-induced VEGF and MMP-9 mRNA expression in MCF-7 cells. Sesamin effectively inhibited the expression of these cytokines to avoid the reinforced induction of VEGF and MMP-9. In conclusion, sesamin potently inhibited macrophage-enhanced proangiogenic activity of breast cancer cells via inhibition of VEGF and MMP-9 induction.

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