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result sql = Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD.
Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD.char = <;code = 60
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result sql = BACKGROUND : Chronic obstructive pulmonary disease is associated with numerous vascular effects including endothelial dysfunction, arterial stiffness and atherogenesis. It is also known that a decline in lung function is associated with increased cardiovascular comorbidity in smokers. The mechanism of this cardiopulmonary dual risk by cigarette smoke (CS) is not known. We studied the molecular mechanisms involved in development of emphysema in atherosclerosis-prone apolipoprotein E-deficient (ApoE-/-) mice in response to CS exposure.
METHODS : Adult male and female wild-type (WT) mice of genetic background C57BL/6J and ApoE-/- mice were exposed to CS, and lung inflammatory responses, oxidative stress (lipid peroxidation products), mechanical properties as well as airspace enlargement were assessed.
RESULTS AND DISCUSSION : The lungs of ApoE-/- mice showed augmented inflammatory response and increased oxidative stress with development of distal airspace enlargement which was accompanied with decline in lung function. Interestingly, the levels and activities of matrix metalloproteinases (MMP-9 and MMP-12) were increased, whereas the level of eNOS was decreased in lungs of CS-exposed ApoE-/- mice as compared to air-exposed ApoE-/- mice or CS-exposed WT mice.
CONCLUSION : These findings suggest that CS causes premature emphysema and a decline of lung function in mice susceptible to cardiovascular abnormalities via abnormal lung inflammation, increased oxidative stress and alterations in levels of MMPs and eNOS.
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char = l;code = 108
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char = o;code = 111
char = s;code = 115
char = i;code = 105
char = s;code = 115
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char = p;code = 112
char = r;code = 114
char = o;code = 111
char = n;code = 110
char = e;code = 101
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char = m;code = 109
char = i;code = 105
char = c;code = 99
char = e;code = 101
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char = b;code = 98
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char = ;code = 32
char = c;code = 99
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char = g;code = 103
char = a;code = 97
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char = t;code = 116
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = m;code = 109
char = o;code = 111
char = k;code = 107
char = e;code = 101
char = :;code = 58
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char = i;code = 105
char = m;code = 109
char = p;code = 112
char = l;code = 108
char = i;code = 105
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char = i;code = 105
char = o;code = 111
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char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = o;code = 111
char = r;code = 114
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char = i;code = 105
char = d;code = 100
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = C;code = 67
char = O;code = 79
char = P;code = 80
char = D;code = 68
char = .;code = 46
result sql = Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD.
char = b;code = 98
char = >;code = 62
char = B;code = 66
char = A;code = 65
char = C;code = 67
char = K;code = 75
char = G;code = 71
char = R;code = 82
char = O;code = 79
char = U;code = 85
char = N;code = 78
char = D;code = 68
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = C;code = 67
char = h;code = 104
char = r;code = 114
char = o;code = 111
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char = i;code = 105
char = c;code = 99
char = ;code = 32
char = o;code = 111
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char = t;code = 116
char = r;code = 114
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char = t;code = 116
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char = v;code = 118
char = e;code = 101
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char = p;code = 112
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char = l;code = 108
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char = a;code = 97
char = r;code = 114
char = y;code = 121
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char = s;code = 115
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = o;code = 111
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = m;code = 109
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char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = g;code = 103
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char = d;code = 100
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char = h;code = 104
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char = i;code = 105
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char = l;code = 108
char = ;code = 32
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char = i;code = 105
char = o;code = 111
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char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = f;code = 102
char = f;code = 102
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = a;code = 97
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char = h;code = 104
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char = o;code = 111
char = g;code = 103
char = e;code = 101
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char = e;code = 101
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char = s;code = 115
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = t;code = 116
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char = i;code = 105
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char = ;code = 32
char = a;code = 97
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char = s;code = 115
char = o;code = 111
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char = k;code = 107
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char = o;code = 111
char = w;code = 119
char = n;code = 110
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char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = e;code = 101
char = c;code = 99
char = l;code = 108
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char = i;code = 105
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char = l;code = 108
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char = g;code = 103
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char = f;code = 102
char = u;code = 117
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char = o;code = 111
char = n;code = 110
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char = i;code = 105
char = s;code = 115
char = ;code = 32
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char = s;code = 115
char = s;code = 115
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char = t;code = 116
char = e;code = 101
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char = t;code = 116
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char = i;code = 105
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char = r;code = 114
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char = m;code = 109
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char = k;code = 107
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char = r;code = 114
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
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char = e;code = 101
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char = s;code = 115
char = m;code = 109
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = d;code = 100
char = i;code = 105
char = o;code = 111
char = p;code = 112
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char = m;code = 109
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char = d;code = 100
char = u;code = 117
char = a;code = 97
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char = r;code = 114
char = i;code = 105
char = s;code = 115
char = k;code = 107
char = ;code = 32
char = b;code = 98
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char = c;code = 99
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char = g;code = 103
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char = e;code = 101
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char = t;code = 116
char = e;code = 101
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char = o;code = 111
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char = ;code = 32
char = (;code = 40
char = C;code = 67
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char = ;code = 32
char = W;code = 87
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char = s;code = 115
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result sql = BACKGROUND : Chronic obstructive pulmonary disease is associated with numerous vascular effects including endothelial dysfunction, arterial stiffness and atherogenesis. It is also known that a decline in lung function is associated with increased cardiovascular comorbidity in smokers. The mechanism of this cardiopulmonary dual risk by cigarette smoke (CS) is not known. We studied the molecular mechanisms involved in development of emphysema in atherosclerosis-prone apolipoprotein E-deficient (ApoE-/-) mice in response to CS exposure.
METHODS : Adult male and female wild-type (WT) mice of genetic background C57BL/6J and ApoE-/- mice were exposed to CS, and lung inflammatory responses, oxidative stress (lipid peroxidation products), mechanical properties as well as airspace enlargement were assessed.
RESULTS AND DISCUSSION : The lungs of ApoE-/- mice showed augmented inflammatory response and increased oxidative stress with development of distal airspace enlargement which was accompanied with decline in lung function. Interestingly, the levels and activities of matrix metalloproteinases (MMP-9 and MMP-12) were increased, whereas the level of eNOS was decreased in lungs of CS-exposed ApoE-/- mice as compared to air-exposed ApoE-/- mice or CS-exposed WT mice.
CONCLUSION : These findings suggest that CS causes premature emphysema and a decline of lung function in mice susceptible to cardiovascular abnormalities via abnormal lung inflammation, increased oxidative stress and alterations in levels of MMPs and eNOS.
Publication: J Inflamm (Lond) 2010 ;7:34. :doi: 10.1186/1476-9255-7-34.
Publication Date: 2010
Study Author(s): Arunachalam, Gnanapragasam;Sundar, Isaac K;Hwang, Jae-Woong;Yao, Hongwei;Rahman, Irfan;
Institution: Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, USA. [email protected].
Shortcut link to this study:
Publication Date: 2010
Study Author(s): Arunachalam, Gnanapragasam;Sundar, Isaac K;Hwang, Jae-Woong;Yao, Hongwei;Rahman, Irfan;
Institution: Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY, USA. [email protected].
Shortcut link to this study:
BACKGROUND : Chronic obstructive pulmonary disease is associated with numerous vascular effects including endothelial dysfunction, arterial stiffness and atherogenesis. It is also known that a decline in lung function is associated with increased cardiovascular comorbidity in smokers. The mechanism of this cardiopulmonary dual risk by cigarette smoke (CS) is not known. We studied the molecular mechanisms involved in development of emphysema in atherosclerosis-prone apolipoprotein E-deficient (ApoE-/-) mice in response to CS exposure.
METHODS : Adult male and female wild-type (WT) mice of genetic background C57BL/6J and ApoE-/- mice were exposed to CS, and lung inflammatory responses, oxidative stress (lipid peroxidation products), mechanical properties as well as airspace enlargement were assessed.
RESULTS AND DISCUSSION : The lungs of ApoE-/- mice showed augmented inflammatory response and increased oxidative stress with development of distal airspace enlargement which was accompanied with decline in lung function. Interestingly, the levels and activities of matrix metalloproteinases (MMP-9 and MMP-12) were increased, whereas the level of eNOS was decreased in lungs of CS-exposed ApoE-/- mice as compared to air-exposed ApoE-/- mice or CS-exposed WT mice.
CONCLUSION : These findings suggest that CS causes premature emphysema and a decline of lung function in mice susceptible to cardiovascular abnormalities via abnormal lung inflammation, increased oxidative stress and alterations in levels of MMPs and eNOS.
METHODS : Adult male and female wild-type (WT) mice of genetic background C57BL/6J and ApoE-/- mice were exposed to CS, and lung inflammatory responses, oxidative stress (lipid peroxidation products), mechanical properties as well as airspace enlargement were assessed.
RESULTS AND DISCUSSION : The lungs of ApoE-/- mice showed augmented inflammatory response and increased oxidative stress with development of distal airspace enlargement which was accompanied with decline in lung function. Interestingly, the levels and activities of matrix metalloproteinases (MMP-9 and MMP-12) were increased, whereas the level of eNOS was decreased in lungs of CS-exposed ApoE-/- mice as compared to air-exposed ApoE-/- mice or CS-exposed WT mice.
CONCLUSION : These findings suggest that CS causes premature emphysema and a decline of lung function in mice susceptible to cardiovascular abnormalities via abnormal lung inflammation, increased oxidative stress and alterations in levels of MMPs and eNOS.
PMID: 20663150
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