|
|
char = T;code = 84
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char = o;code = 111
char = m;code = 109
char = i;code = 105
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char = ;code = 32
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char = n;code = 110
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char = m;code = 109
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char = a;code = 97
char = m;code = 109
char = m;code = 109
char = a;code = 97
char = t;code = 116
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char = y;code = 121
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char = ;code = 32
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char = p;code = 112
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char = c;code = 99
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char = t;code = 116
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char = e;code = 101
char = r;code = 114
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char = .;code = 46
result sql = Thalidomide and analogues: potential for immunomodulation of inflammatory and neoplastic dermatologic disorders.
Thalidomide and analogues: potential for immunomodulation of inflammatory and neoplastic dermatologic disorders.char = T;code = 84
char = h;code = 104
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char = i;code = 105
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char = s;code = 115
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char = T;code = 84
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char = U;code = 85
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char = A;code = 65
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char = a;code = 97
char = t;code = 116
char = i;code = 105
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char = ;code = 32
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char = o;code = 111
char = r;code = 114
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char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = m;code = 109
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char = o;code = 111
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char = ;code = 32
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char = r;code = 114
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char = s;code = 115
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char = s;code = 115
char = s;code = 115
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char = t;code = 116
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char = r;code = 114
char = o;code = 111
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char = ;code = 32
char = l;code = 108
char = e;code = 101
char = p;code = 112
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char = r;code = 114
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char = n;code = 110
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char = l;code = 108
char = ;code = 32
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char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = l;code = 108
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
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char = h;code = 104
char = e;code = 101
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char = T;code = 84
char = ;code = 32
char = c;code = 99
char = e;code = 101
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char = l;code = 108
char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = u;code = 117
char = t;code = 116
char = h;code = 104
char = o;code = 111
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char = e;code = 101
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char = h;code = 104
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char = s;code = 115
char = i;code = 105
char = z;code = 122
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char = d;code = 100
char = v;code = 118
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = u;code = 117
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = T;code = 84
char = -;code = 45
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char = l;code = 108
char = l;code = 108
char = ;code = 32
char = s;code = 115
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char = s;code = 115
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char = t;code = 116
char = s;code = 115
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = h;code = 104
char = u;code = 117
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = k;code = 107
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = s;code = 115
char = o;code = 111
char = r;code = 114
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = Thalidomide and analogues are a class of immunomodulatory drugs or IMiDS. Thalidomide was initially approved by the U.S. Food and Drug Administation for treatment of erythema nodosum in leprosy and is now approved for multiple myeloma as well. A second generation IMiD, lenalidomide, is also approved for multiple myeloma and refractory myelodysplastic syndrome. Discovery of this class of drugs has been serendipitous and empirical, as the drug targets have been unknown. In this review, the authors integrate recent identification of drug targets of IMiDS, which include the inducible form of nitric oxide synthase (iNOS), Rho GTPase and caspase-1, with the developments in the understanding of the molecular biology of human inflammatory, infectious and neoplastic skin disorders. Because thalidomide reemerged through leprosy, the original disease classified by the T cell, the authors have also emphasized advances in the understanding of T-cell subsets in human skin disorders.
char = h;code = 104
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char = i;code = 105
char = d;code = 100
char = o;code = 111
char = m;code = 109
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = u;code = 117
char = e;code = 101
char = s;code = 115
char = :;code = 58
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = m;code = 109
char = u;code = 117
char = n;code = 110
char = o;code = 111
char = m;code = 109
char = o;code = 111
char = d;code = 100
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
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char = l;code = 108
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char = m;code = 109
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char = r;code = 114
char = y;code = 121
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = n;code = 110
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char = o;code = 111
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = d;code = 100
char = e;code = 101
char = r;code = 114
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = i;code = 105
char = c;code = 99
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char = d;code = 100
char = i;code = 105
char = s;code = 115
char = o;code = 111
char = r;code = 114
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = .;code = 46
result sql = Thalidomide and analogues: potential for immunomodulation of inflammatory and neoplastic dermatologic disorders.
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char = d;code = 100
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char = I;code = 73
char = M;code = 77
char = i;code = 105
char = D;code = 68
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char = a;code = 97
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char = p;code = 112
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char = a;code = 97
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char = i;code = 105
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char = s;code = 115
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char = o;code = 111
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char = e;code = 101
char = .;code = 46
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char = s;code = 115
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char = n;code = 110
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char = ;code = 32
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result sql = Thalidomide and analogues are a class of immunomodulatory drugs or IMiDS. Thalidomide was initially approved by the U.S. Food and Drug Administation for treatment of erythema nodosum in leprosy and is now approved for multiple myeloma as well. A second generation IMiD, lenalidomide, is also approved for multiple myeloma and refractory myelodysplastic syndrome. Discovery of this class of drugs has been serendipitous and empirical, as the drug targets have been unknown. In this review, the authors integrate recent identification of drug targets of IMiDS, which include the inducible form of nitric oxide synthase (iNOS), Rho GTPase and caspase-1, with the developments in the understanding of the molecular biology of human inflammatory, infectious and neoplastic skin disorders. Because thalidomide reemerged through leprosy, the original disease classified by the T cell, the authors have also emphasized advances in the understanding of T-cell subsets in human skin disorders.
Publication: J Drugs Dermatol 2010 Jul ;9(7)::814-26.
Publication Date: 2010 Jul
Study Author(s): Ladizinski, Barry;Shannon, Edward J;Sanchez, Miguel R;Levis, William R;
Institution: Dartmouth Medical School, Hanover, NH, USA.
Shortcut link to this study:
Publication Date: 2010 Jul
Study Author(s): Ladizinski, Barry;Shannon, Edward J;Sanchez, Miguel R;Levis, William R;
Institution: Dartmouth Medical School, Hanover, NH, USA.
Shortcut link to this study:
Thalidomide and analogues are a class of immunomodulatory drugs or IMiDS. Thalidomide was initially approved by the U.S. Food and Drug Administation for treatment of erythema nodosum in leprosy and is now approved for multiple myeloma as well. A second generation IMiD, lenalidomide, is also approved for multiple myeloma and refractory myelodysplastic syndrome. Discovery of this class of drugs has been serendipitous and empirical, as the drug targets have been unknown. In this review, the authors integrate recent identification of drug targets of IMiDS, which include the inducible form of nitric oxide synthase (iNOS), Rho GTPase and caspase-1, with the developments in the understanding of the molecular biology of human inflammatory, infectious and neoplastic skin disorders. Because thalidomide reemerged through leprosy, the original disease classified by the T cell, the authors have also emphasized advances in the understanding of T-cell subsets in human skin disorders.
PMID: 20677538
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