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result sql = (-)-Epigallocatethin-3-O-gallate counteracts caffeine-induced hyperactivity: evidence of dopaminergic blockade.
(-)-Epigallocatethin-3-O-gallate counteracts caffeine-induced hyperactivity: evidence of dopaminergic blockade.char = T;code = 84
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char = f;code = 102
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result sql = This experiment was designed to know whether (-)-epigallocatethin-3-O-gallate (EGCG) counteracts caffeine-induced hyperactivity, and its potential mechanisms in mice. EGCG inhibited methamphetamine-induced, cocaine-induced and caffeine-induced horizontal hyperlocomotion and rearing activity. EGCG also inhibited hyperlocomotion and rearing activity induced by apomorphine, a D1/D2-like agonist. Moreover, EGCG inhibited climbing behavior, a typical stereotyped behavior induced by stimulation of dopamine receptors through the activation of those receptors by apomorphine. From this experiment, we suggest that EGCG inhibits hyperactivity induced by psychostimulants including caffeine, in part by modulating dopaminergic transmission, and these inhibitory effects of EGCG counteract the stimulant actions of caffeine in green tea.
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char = l;code = 108
char = o;code = 111
char = c;code = 99
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char = t;code = 116
char = e;code = 101
char = t;code = 116
char = h;code = 104
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char = 3;code = 51
char = -;code = 45
char = O;code = 79
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char = l;code = 108
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char = e;code = 101
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char = c;code = 99
char = o;code = 111
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char = e;code = 101
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char = c;code = 99
char = t;code = 116
char = s;code = 115
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char = c;code = 99
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char = f;code = 102
char = e;code = 101
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char = i;code = 105
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char = d;code = 100
char = o;code = 111
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char = a;code = 97
char = m;code = 109
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char = n;code = 110
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char = r;code = 114
char = g;code = 103
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = b;code = 98
char = l;code = 108
char = o;code = 111
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char = d;code = 100
char = e;code = 101
char = .;code = 46
result sql = (-)-Epigallocatethin-3-O-gallate counteracts caffeine-induced hyperactivity: evidence of dopaminergic blockade.
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char = G;code = 71
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char = e;code = 101
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char = t;code = 116
char = h;code = 104
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char = ;code = 32
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result sql = This experiment was designed to know whether (-)-epigallocatethin-3-O-gallate (EGCG) counteracts caffeine-induced hyperactivity, and its potential mechanisms in mice. EGCG inhibited methamphetamine-induced, cocaine-induced and caffeine-induced horizontal hyperlocomotion and rearing activity. EGCG also inhibited hyperlocomotion and rearing activity induced by apomorphine, a D1/D2-like agonist. Moreover, EGCG inhibited climbing behavior, a typical stereotyped behavior induced by stimulation of dopamine receptors through the activation of those receptors by apomorphine. From this experiment, we suggest that EGCG inhibits hyperactivity induced by psychostimulants including caffeine, in part by modulating dopaminergic transmission, and these inhibitory effects of EGCG counteract the stimulant actions of caffeine in green tea.
Publication: Behav Pharmacol 2010 Sep ;21(5-6)::572-5.
Publication Date: 2010 Sep
Study Author(s): Park, Kwang-Soon;Eun, Jae Soon;Kim, Hyoung-Chun;Moon, Dong-Cheul;Hong, Jin-Tae;Oh, Ki-Wan;
Institution: College of Pharmacy, Chungbuk National University, Cheongju, Korea.
Shortcut link to this study:
Publication Date: 2010 Sep
Study Author(s): Park, Kwang-Soon;Eun, Jae Soon;Kim, Hyoung-Chun;Moon, Dong-Cheul;Hong, Jin-Tae;Oh, Ki-Wan;
Institution: College of Pharmacy, Chungbuk National University, Cheongju, Korea.
Shortcut link to this study:
This experiment was designed to know whether (-)-epigallocatethin-3-O-gallate (EGCG) counteracts caffeine-induced hyperactivity, and its potential mechanisms in mice. EGCG inhibited methamphetamine-induced, cocaine-induced and caffeine-induced horizontal hyperlocomotion and rearing activity. EGCG also inhibited hyperlocomotion and rearing activity induced by apomorphine, a D1/D2-like agonist. Moreover, EGCG inhibited climbing behavior, a typical stereotyped behavior induced by stimulation of dopamine receptors through the activation of those receptors by apomorphine. From this experiment, we suggest that EGCG inhibits hyperactivity induced by psychostimulants including caffeine, in part by modulating dopaminergic transmission, and these inhibitory effects of EGCG counteract the stimulant actions of caffeine in green tea.
PMID: 20700049
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