|
|
char = S;code = 83
char = u;code = 117
char = n;code = 110
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char = g;code = 103
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char = t;code = 116
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = i;code = 105
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char = g;code = 103
char = e;code = 101
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char = d;code = 100
char = e;code = 101
char = f;code = 102
char = o;code = 111
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char = m;code = 109
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = o;code = 111
char = m;code = 109
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = L;code = 76
char = e;code = 101
char = i;code = 105
char = s;code = 115
char = h;code = 104
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = a;code = 97
char = ;code = 32
char = b;code = 98
char = r;code = 114
char = a;code = 97
char = z;code = 122
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = o;code = 111
char = ;code = 32
char = l;code = 108
char = e;code = 101
char = i;code = 105
char = s;code = 115
char = h;code = 104
char = m;code = 109
char = a;code = 97
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char = c;code = 99
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char = d;code = 100
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char = l;code = 108
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char = i;code = 105
char = n;code = 110
char = ;code = 32
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char = d;code = 100
char = a;code = 97
char = r;code = 114
char = k;code = 107
char = .;code = 46
result sql = Sunlight triggered photodynamic ultradeformable liposomes against Leishmania braziliensis are also leishmanicidal in the dark.
Sunlight triggered photodynamic ultradeformable liposomes against Leishmania braziliensis are also leishmanicidal in the dark.char = B;code = 66
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char = e;code = 101
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char = d;code = 100
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char = n;code = 110
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char = i;code = 105
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char = l;code = 108
char = ;code = 32
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char = o;code = 111
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char = e;code = 101
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char = s;code = 115
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char = ;code = 32
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char = f;code = 102
char = ;code = 32
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char = d;code = 100
char = m;code = 109
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char = e;code = 101
char = d;code = 100
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char = g;code = 103
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char = d;code = 100
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char = a;code = 97
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char = a;code = 97
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char = y;code = 121
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char = a;code = 97
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char = m;code = 109
char = e;code = 101
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char = t;code = 116
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char = f;code = 102
char = o;code = 111
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char = o;code = 111
char = m;code = 109
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char = e;code = 101
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char = n;code = 110
char = P;code = 80
char = c;code = 99
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char = a;code = 97
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char = o;code = 111
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char = u;code = 117
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = d;code = 100
char = e;code = 101
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char = e;code = 101
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char = m;code = 109
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = Z;code = 90
char = n;code = 110
char = P;code = 80
char = c;code = 99
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = f;code = 102
char = i;code = 105
char = r;code = 114
char = m;code = 109
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = U;code = 85
char = D;code = 68
char = L;code = 76
char = -;code = 45
char = Z;code = 90
char = n;code = 110
char = P;code = 80
char = c;code = 99
char = ;code = 32
char = p;code = 112
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = h;code = 104
char = o;code = 111
char = m;code = 109
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = o;code = 111
char = u;code = 117
char = s;code = 115
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = r;code = 114
char = n;code = 110
char = e;code = 101
char = u;code = 117
char = m;code = 109
char = ,;code = 44
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = r;code = 114
char = y;code = 121
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = 7;code = 55
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = l;code = 108
char = d;code = 100
char = s;code = 115
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = m;code = 109
char = o;code = 111
char = u;code = 117
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = Z;code = 90
char = n;code = 110
char = P;code = 80
char = c;code = 99
char = ;code = 32
char = 8;code = 56
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = l;code = 108
char = d;code = 100
char = s;code = 115
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = e;code = 101
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = L;code = 76
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char = Z;code = 90
char = n;code = 110
char = P;code = 80
char = c;code = 99
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char = ;code = 32
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char = t;code = 116
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = e;code = 101
char = n;code = 110
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char = i;code = 105
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = i;code = 105
char = p;code = 112
char = l;code = 108
char = e;code = 101
char = ;code = 32
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = U;code = 85
char = D;code = 68
char = L;code = 76
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char = s;code = 115
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = r;code = 114
char = o;code = 111
char = l;code = 108
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char = n;code = 110
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = p;code = 112
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char = y;code = 121
char = l;code = 108
char = a;code = 97
char = x;code = 120
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = e;code = 101
char = u;code = 117
char = t;code = 116
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char = a;code = 97
char = t;code = 116
char = ;code = 32
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = l;code = 108
char = y;code = 121
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char = s;code = 115
char = t;code = 116
char = a;code = 97
char = g;code = 103
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = Being independent of artificial power sources, self administered sunlight triggered photodynamic therapy could be a suitable alternative treatment for cutaneous leishmaniasis, that avoids the need for injectables and the toxic side effects of pentavalent antimonials. In this work we have determined the in vitro leishmanicidal activity of sunlight triggered photodynamic ultradeformable liposomes (UDL). ZnPc is a hydrophobic Zn phthalocyanine that showed 20% anti-promastigote activity (APA) and 20% anti-amastigote activity (AA) against Leishmania braziliensis (strain 2903) after 15min sunlight irradiation (15J/cm(2)). However, when loaded in UDL as UDL-ZnPc (1.25μM ZnPc-1mM phospholipids) it elicited 100% APA and 80% AA at the same light dose. In the absence of host cell toxicity, UDL and UDL-ZnPc also showed non-photodynamic leishmanicidal activity. Confocal laser scanning microscopy of cryosectioned human skin mounted in non-occlusive Saarbrücken Penetration Model, showed that upon transcutaneous administration ZnPc penetrated nearly 10 folds deeper as UDL-ZnPc than if loaded in conventional liposomes (L-ZnPc). Quantitative determination of ZnPc confirmed that UDL-ZnPc penetrated homogeneously in the stratum corneum, carrying 7 folds higher amount of ZnPc 8 folds deeper than L-ZnPc. It is envisioned that the multiple leishmanicidal effects of UDL-ZnPc could play a synergistic role in prophylaxis or therapeutic at early stages of the infection.
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char = n;code = 110
char = l;code = 108
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = t;code = 116
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char = t;code = 116
char = r;code = 114
char = i;code = 105
char = g;code = 103
char = g;code = 103
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = t;code = 116
char = o;code = 111
char = d;code = 100
char = y;code = 121
char = n;code = 110
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = d;code = 100
char = e;code = 101
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = o;code = 111
char = m;code = 109
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = L;code = 76
char = e;code = 101
char = i;code = 105
char = s;code = 115
char = h;code = 104
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = a;code = 97
char = ;code = 32
char = b;code = 98
char = r;code = 114
char = a;code = 97
char = z;code = 122
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = o;code = 111
char = ;code = 32
char = l;code = 108
char = e;code = 101
char = i;code = 105
char = s;code = 115
char = h;code = 104
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = d;code = 100
char = a;code = 97
char = r;code = 114
char = k;code = 107
char = .;code = 46
result sql = Sunlight triggered photodynamic ultradeformable liposomes against Leishmania braziliensis are also leishmanicidal in the dark.
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char = o;code = 111
char = u;code = 117
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char = c;code = 99
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char = i;code = 105
char = n;code = 110
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char = s;code = 115
char = t;code = 116
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char = e;code = 101
char = d;code = 100
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char = h;code = 104
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char = t;code = 116
char = r;code = 114
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char = g;code = 103
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = d;code = 100
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char = h;code = 104
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char = t;code = 116
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char = a;code = 97
char = m;code = 109
char = i;code = 105
char = c;code = 99
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = y;code = 121
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char = c;code = 99
char = o;code = 111
char = u;code = 117
char = l;code = 108
char = d;code = 100
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char = b;code = 98
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = s;code = 115
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char = i;code = 105
char = t;code = 116
char = a;code = 97
char = b;code = 98
char = l;code = 108
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char = a;code = 97
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char = r;code = 114
char = n;code = 110
char = a;code = 97
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char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = m;code = 109
char = e;code = 101
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char = t;code = 116
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char = o;code = 111
char = r;code = 114
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char = c;code = 99
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char = t;code = 116
char = a;code = 97
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char = e;code = 101
char = o;code = 111
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char = s;code = 115
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char = l;code = 108
char = e;code = 101
char = i;code = 105
char = s;code = 115
char = h;code = 104
char = m;code = 109
char = a;code = 97
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char = i;code = 105
char = a;code = 97
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char = i;code = 105
char = s;code = 115
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = a;code = 97
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char = o;code = 111
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char = d;code = 100
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = n;code = 110
char = e;code = 101
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = j;code = 106
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = s;code = 115
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = d;code = 100
char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = p;code = 112
char = e;code = 101
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char = t;code = 116
char = a;code = 97
char = v;code = 118
char = a;code = 97
char = l;code = 108
char = e;code = 101
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char = t;code = 116
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = m;code = 109
char = o;code = 111
char = n;code = 110
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = o;code = 111
char = r;code = 114
char = k;code = 107
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
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char = d;code = 100
char = e;code = 101
char = t;code = 116
char = e;code = 101
char = r;code = 114
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char = i;code = 105
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = i;code = 105
char = n;code = 110
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char = v;code = 118
char = i;code = 105
char = t;code = 116
char = r;code = 114
char = o;code = 111
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char = l;code = 108
char = e;code = 101
char = i;code = 105
char = s;code = 115
char = h;code = 104
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = d;code = 100
char = a;code = 97
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char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
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char = i;code = 105
char = t;code = 116
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char = f;code = 102
char = ;code = 32
char = s;code = 115
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char = l;code = 108
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = g;code = 103
char = g;code = 103
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = t;code = 116
char = o;code = 111
char = d;code = 100
char = y;code = 121
char = n;code = 110
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = c;code = 99
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char = u;code = 117
char = l;code = 108
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = d;code = 100
char = e;code = 101
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
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char = l;code = 108
char = i;code = 105
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = o;code = 111
char = m;code = 109
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = U;code = 85
char = D;code = 68
char = L;code = 76
char = );code = 41
char = .;code = 46
char = ;code = 32
char = Z;code = 90
char = n;code = 110
char = P;code = 80
char = c;code = 99
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = b;code = 98
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = Z;code = 90
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = h;code = 104
char = t;code = 116
char = h;code = 104
char = a;code = 97
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char = o;code = 111
char = c;code = 99
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char = a;code = 97
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char = i;code = 105
char = n;code = 110
char = e;code = 101
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char = t;code = 116
char = h;code = 104
char = a;code = 97
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char = ;code = 32
char = s;code = 115
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char = a;code = 97
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char = i;code = 105
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char = o;code = 111
char = m;code = 109
char = a;code = 97
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char = t;code = 116
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char = g;code = 103
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char = a;code = 97
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char = v;code = 118
char = i;code = 105
char = t;code = 116
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char = A;code = 65
char = P;code = 80
char = A;code = 65
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char = ;code = 32
char = a;code = 97
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char = ;code = 32
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char = a;code = 97
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char = a;code = 97
char = s;code = 115
char = t;code = 116
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char = a;code = 97
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char = i;code = 105
char = t;code = 116
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char = A;code = 65
char = A;code = 65
char = );code = 41
char = ;code = 32
char = a;code = 97
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char = a;code = 97
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char = n;code = 110
char = s;code = 115
char = t;code = 116
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char = L;code = 76
char = e;code = 101
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char = s;code = 115
char = h;code = 104
char = m;code = 109
char = a;code = 97
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char = i;code = 105
char = a;code = 97
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char = b;code = 98
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char = a;code = 97
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char = i;code = 105
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char = s;code = 115
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char = s;code = 115
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char = s;code = 115
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = i;code = 105
char = n;code = 110
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char = 2;code = 50
char = 9;code = 57
char = 0;code = 48
char = 3;code = 51
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char = ;code = 32
char = a;code = 97
char = f;code = 102
char = t;code = 116
char = e;code = 101
char = r;code = 114
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char = 1;code = 49
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char = m;code = 109
char = i;code = 105
char = n;code = 110
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char = s;code = 115
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char = n;code = 110
char = l;code = 108
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = t;code = 116
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char = i;code = 105
char = r;code = 114
char = r;code = 114
char = a;code = 97
char = d;code = 100
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = (;code = 40
char = 1;code = 49
char = 5;code = 53
char = J;code = 74
char = /;code = 47
char = c;code = 99
char = m;code = 109
char = (;code = 40
char = 2;code = 50
char = );code = 41
char = );code = 41
char = .;code = 46
char = ;code = 32
char = H;code = 72
char = o;code = 111
char = w;code = 119
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = h;code = 104
char = e;code = 101
char = n;code = 110
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char = l;code = 108
char = o;code = 111
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = U;code = 85
char = D;code = 68
char = L;code = 76
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = U;code = 85
char = D;code = 68
char = L;code = 76
char = -;code = 45
char = Z;code = 90
char = n;code = 110
char = P;code = 80
char = c;code = 99
char = ;code = 32
char = (;code = 40
char = 1;code = 49
char = .;code = 46
char = 2;code = 50
char = 5;code = 53
char = &;code = 38
char = #;code = 35
char = 9;code = 57
char = 5;code = 53
char = 6;code = 54
char = ;;code = 59
char = M;code = 77
char = ;code = 32
char = Z;code = 90
char = n;code = 110
char = P;code = 80
char = c;code = 99
char = -;code = 45
char = 1;code = 49
char = m;code = 109
char = M;code = 77
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char = p;code = 112
char = h;code = 104
char = o;code = 111
char = s;code = 115
char = p;code = 112
char = h;code = 104
char = o;code = 111
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char = i;code = 105
char = p;code = 112
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char = d;code = 100
char = s;code = 115
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char = ;code = 32
char = i;code = 105
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char = i;code = 105
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char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = 1;code = 49
char = 0;code = 48
char = 0;code = 48
char = %;code = 37
char = ;code = 32
char = A;code = 65
char = P;code = 80
char = A;code = 65
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = 8;code = 56
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char = %;code = 37
char = ;code = 32
char = A;code = 65
char = A;code = 65
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char = a;code = 97
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char = ;code = 32
char = t;code = 116
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char = e;code = 101
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char = ;code = 32
char = I;code = 73
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char = e;code = 101
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char = a;code = 97
char = b;code = 98
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char = f;code = 102
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char = s;code = 115
char = t;code = 116
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char = c;code = 99
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char = l;code = 108
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char = t;code = 116
char = o;code = 111
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char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = ;code = 32
char = U;code = 85
char = D;code = 68
char = L;code = 76
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = U;code = 85
char = D;code = 68
char = L;code = 76
char = -;code = 45
char = Z;code = 90
char = n;code = 110
char = P;code = 80
char = c;code = 99
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char = a;code = 97
char = l;code = 108
char = s;code = 115
char = o;code = 111
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char = s;code = 115
char = h;code = 104
char = o;code = 111
char = w;code = 119
char = e;code = 101
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char = a;code = 97
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char = i;code = 105
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char = a;code = 97
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char = a;code = 97
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char = t;code = 116
char = i;code = 105
char = v;code = 118
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char = t;code = 116
char = y;code = 121
char = .;code = 46
char = ;code = 32
char = C;code = 67
char = o;code = 111
char = n;code = 110
char = f;code = 102
char = o;code = 111
char = c;code = 99
char = a;code = 97
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char = l;code = 108
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = r;code = 114
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char = s;code = 115
char = c;code = 99
char = a;code = 97
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char = n;code = 110
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char = n;code = 110
char = g;code = 103
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char = m;code = 109
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char = c;code = 99
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = c;code = 99
char = o;code = 111
char = p;code = 112
char = y;code = 121
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = r;code = 114
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char = s;code = 115
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char = c;code = 99
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char = i;code = 105
char = o;code = 111
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = h;code = 104
char = u;code = 117
char = m;code = 109
char = a;code = 97
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char = s;code = 115
char = k;code = 107
char = i;code = 105
char = n;code = 110
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char = m;code = 109
char = o;code = 111
char = u;code = 117
char = n;code = 110
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = n;code = 110
char = -;code = 45
char = o;code = 111
char = c;code = 99
char = c;code = 99
char = l;code = 108
char = u;code = 117
char = s;code = 115
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = S;code = 83
char = a;code = 97
char = a;code = 97
char = r;code = 114
char = b;code = 98
char = r;code = 114
char = &;code = 38
char = #;code = 35
char = 2;code = 50
char = 5;code = 53
char = 2;code = 50
char = ;;code = 59
char = c;code = 99
char = k;code = 107
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = P;code = 80
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
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result sql = Being independent of artificial power sources, self administered sunlight triggered photodynamic therapy could be a suitable alternative treatment for cutaneous leishmaniasis, that avoids the need for injectables and the toxic side effects of pentavalent antimonials. In this work we have determined the in vitro leishmanicidal activity of sunlight triggered photodynamic ultradeformable liposomes (UDL). ZnPc is a hydrophobic Zn phthalocyanine that showed 20% anti-promastigote activity (APA) and 20% anti-amastigote activity (AA) against Leishmania braziliensis (strain 2903) after 15min sunlight irradiation (15J/cm(2)). However, when loaded in UDL as UDL-ZnPc (1.25μM ZnPc-1mM phospholipids) it elicited 100% APA and 80% AA at the same light dose. In the absence of host cell toxicity, UDL and UDL-ZnPc also showed non-photodynamic leishmanicidal activity. Confocal laser scanning microscopy of cryosectioned human skin mounted in non-occlusive Saarbrücken Penetration Model, showed that upon transcutaneous administration ZnPc penetrated nearly 10 folds deeper as UDL-ZnPc than if loaded in conventional liposomes (L-ZnPc). Quantitative determination of ZnPc confirmed that UDL-ZnPc penetrated homogeneously in the stratum corneum, carrying 7 folds higher amount of ZnPc 8 folds deeper than L-ZnPc. It is envisioned that the multiple leishmanicidal effects of UDL-ZnPc could play a synergistic role in prophylaxis or therapeutic at early stages of the infection.
Publication: J Control Release 2010 Nov 1 ;147(3)::368-76. :doi: 10.1016/j.jconrel.2010.08.014.
Publication Date: 2010 Nov 1
Study Author(s): Montanari, Jorge;Maidana, Cristina;Esteva, Mónica Inés;Salomon, Cristina;Morilla, Maria Jose;Romero, Eder L;
Institution: Programa de Nanomedicinas, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Roque Saenz Peña 352, Bernal, B1876 BXD, Buenos Aires, Argentina.
Shortcut link to this study:
Publication Date: 2010 Nov 1
Study Author(s): Montanari, Jorge;Maidana, Cristina;Esteva, Mónica Inés;Salomon, Cristina;Morilla, Maria Jose;Romero, Eder L;
Institution: Programa de Nanomedicinas, Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Roque Saenz Peña 352, Bernal, B1876 BXD, Buenos Aires, Argentina.
Shortcut link to this study:
Being independent of artificial power sources, self administered sunlight triggered photodynamic therapy could be a suitable alternative treatment for cutaneous leishmaniasis, that avoids the need for injectables and the toxic side effects of pentavalent antimonials. In this work we have determined the in vitro leishmanicidal activity of sunlight triggered photodynamic ultradeformable liposomes (UDL). ZnPc is a hydrophobic Zn phthalocyanine that showed 20% anti-promastigote activity (APA) and 20% anti-amastigote activity (AA) against Leishmania braziliensis (strain 2903) after 15min sunlight irradiation (15J/cm(2)). However, when loaded in UDL as UDL-ZnPc (1.25μM ZnPc-1mM phospholipids) it elicited 100% APA and 80% AA at the same light dose. In the absence of host cell toxicity, UDL and UDL-ZnPc also showed non-photodynamic leishmanicidal activity. Confocal laser scanning microscopy of cryosectioned human skin mounted in non-occlusive Saarbrücken Penetration Model, showed that upon transcutaneous administration ZnPc penetrated nearly 10 folds deeper as UDL-ZnPc than if loaded in conventional liposomes (L-ZnPc). Quantitative determination of ZnPc confirmed that UDL-ZnPc penetrated homogeneously in the stratum corneum, carrying 7 folds higher amount of ZnPc 8 folds deeper than L-ZnPc. It is envisioned that the multiple leishmanicidal effects of UDL-ZnPc could play a synergistic role in prophylaxis or therapeutic at early stages of the infection.
PMID: 20727925
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