|
|
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result sql = Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations.
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result sql = Ischemic heart disease (IHD) is the leading cause of death worldwide. Novel cardioprotective strategies are therefore required to improve clinical outcomes in patients with IHD. Although a large number of novel cardioprotective strategies have been discovered in the research laboratory, their translation to the clinical setting has been largely disappointing. The reason for this failure can be attributed to a number of factors including the inadequacy of the animal ischemia-reperfusion injury models used in the preclinical cardioprotection studies and the inappropriate design and execution of the clinical cardioprotection studies. This important issue was the main topic of discussion of the UCL-Hatter Cardiovascular Institute 6th International Cardioprotection Workshop, the outcome of which has been published in this article as the "Hatter Workshop Recommendations". These have been proposed to provide guidance on the design and execution of both preclinical and clinical cardioprotection studies in order to facilitate the translation of future novel cardioprotective strategies for patient benefit.
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result sql = Translating novel strategies for cardioprotection: the Hatter Workshop Recommendations.
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char = v;code = 118
char = e;code = 101
char = l;code = 108
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char = r;code = 114
char = d;code = 100
char = i;code = 105
char = o;code = 111
char = p;code = 112
char = r;code = 114
char = o;code = 111
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char = c;code = 99
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char = e;code = 101
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char = i;code = 105
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char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
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char = e;code = 101
char = f;code = 102
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result sql = Ischemic heart disease (IHD) is the leading cause of death worldwide. Novel cardioprotective strategies are therefore required to improve clinical outcomes in patients with IHD. Although a large number of novel cardioprotective strategies have been discovered in the research laboratory, their translation to the clinical setting has been largely disappointing. The reason for this failure can be attributed to a number of factors including the inadequacy of the animal ischemia-reperfusion injury models used in the preclinical cardioprotection studies and the inappropriate design and execution of the clinical cardioprotection studies. This important issue was the main topic of discussion of the UCL-Hatter Cardiovascular Institute 6th International Cardioprotection Workshop, the outcome of which has been published in this article as the "Hatter Workshop Recommendations". These have been proposed to provide guidance on the design and execution of both preclinical and clinical cardioprotection studies in order to facilitate the translation of future novel cardioprotective strategies for patient benefit.
Publication: Basic Res. Cardiol. 2010 Nov ;105(6)::677-86. :doi: 10.1007/s00395-010-0121-4.
Publication Date: 2010 Nov
Study Author(s): Hausenloy, Derek J;Baxter, Gary;Bell, Robert;Bøtker, Hans Erik;Davidson, Sean M;Downey, James;Heusch, Gerd;Kitakaze, Masafumi;Lecour, Sandrine;Mentzer, Robert;Mocanu, Mihaela M;Ovize, Michel;Schulz, Rainer;Shannon, Richard;Walker, Malcolm;Walkinshaw, Gail;Yellon, Derek M;
Institution: The Hatter Cardiovascular Institute, University College London Hospitals and Medical School, 67 Chenies Mews, London, WC1E 6HX, UK.
Shortcut link to this study:
Publication Date: 2010 Nov
Study Author(s): Hausenloy, Derek J;Baxter, Gary;Bell, Robert;Bøtker, Hans Erik;Davidson, Sean M;Downey, James;Heusch, Gerd;Kitakaze, Masafumi;Lecour, Sandrine;Mentzer, Robert;Mocanu, Mihaela M;Ovize, Michel;Schulz, Rainer;Shannon, Richard;Walker, Malcolm;Walkinshaw, Gail;Yellon, Derek M;
Institution: The Hatter Cardiovascular Institute, University College London Hospitals and Medical School, 67 Chenies Mews, London, WC1E 6HX, UK.
Shortcut link to this study:
Ischemic heart disease (IHD) is the leading cause of death worldwide. Novel cardioprotective strategies are therefore required to improve clinical outcomes in patients with IHD. Although a large number of novel cardioprotective strategies have been discovered in the research laboratory, their translation to the clinical setting has been largely disappointing. The reason for this failure can be attributed to a number of factors including the inadequacy of the animal ischemia-reperfusion injury models used in the preclinical cardioprotection studies and the inappropriate design and execution of the clinical cardioprotection studies. This important issue was the main topic of discussion of the UCL-Hatter Cardiovascular Institute 6th International Cardioprotection Workshop, the outcome of which has been published in this article as the "Hatter Workshop Recommendations". These have been proposed to provide guidance on the design and execution of both preclinical and clinical cardioprotection studies in order to facilitate the translation of future novel cardioprotective strategies for patient benefit.
PMID: 20865418
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