|
|
char = N;code = 78
char = e;code = 101
char = u;code = 117
char = r;code = 114
char = o;code = 111
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = h;code = 104
char = o;code = 111
char = n;code = 110
char = o;code = 111
char = k;code = 107
char = i;code = 105
char = o;code = 111
char = l;code = 108
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char = n;code = 110
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char = l;code = 108
char = o;code = 111
char = l;code = 108
char = ,;code = 44
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = o;code = 111
char = u;code = 117
char = n;code = 110
char = d;code = 100
char = s;code = 115
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = ;code = 32
char = M;code = 77
char = a;code = 97
char = g;code = 103
char = n;code = 110
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = a;code = 97
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = i;code = 105
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = -;code = 45
char = a;code = 97
char = m;code = 109
char = y;code = 121
char = l;code = 108
char = o;code = 111
char = i;code = 105
char = d;code = 100
char = -;code = 45
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = P;code = 80
char = C;code = 67
char = 1;code = 49
char = 2;code = 50
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = .;code = 46
result sql = Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells.
Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells.char = A;code = 65
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char = y;code = 121
char = l;code = 108
char = o;code = 111
char = i;code = 105
char = d;code = 100
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char = &;code = 38
char = #;code = 35
char = 9;code = 57
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char = 6;code = 54
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char = ;code = 32
char = p;code = 112
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char = p;code = 112
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char = i;code = 105
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char = e;code = 101
char = ;code = 32
char = (;code = 40
char = A;code = 65
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char = );code = 41
char = ;code = 32
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char = l;code = 108
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char = i;code = 105
char = c;code = 99
char = h;code = 104
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = g;code = 103
char = h;code = 104
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char = ;code = 32
char = p;code = 112
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char = a;code = 97
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char = ;code = 32
char = a;code = 97
char = ;code = 32
char = r;code = 114
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char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = A;code = 65
char = l;code = 108
char = z;code = 122
char = h;code = 104
char = e;code = 101
char = i;code = 105
char = m;code = 109
char = e;code = 101
char = r;code = 114
char = ';code = 39
char = s;code = 115
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = s;code = 115
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = ;code = 32
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char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = g;code = 103
char = a;code = 97
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char = d;code = 100
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char = h;code = 104
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char = f;code = 102
char = e;code = 101
char = c;code = 99
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char = ;code = 32
char = A;code = 65
char = &;code = 38
char = #;code = 35
char = 9;code = 57
char = 4;code = 52
char = 6;code = 54
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char = ;code = 32
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = A;code = 65
char = &;code = 38
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char = 6;code = 54
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char = n;code = 110
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char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = g;code = 103
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char = n;code = 110
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = n;code = 110
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char = r;code = 114
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char = ;code = 32
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char = o;code = 111
char = u;code = 117
char = n;code = 110
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char = ;code = 32
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char = t;code = 116
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = E;code = 69
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char = &;code = 38
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char = 5;code = 53
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char = a;code = 97
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char = ,;code = 44
char = ;code = 32
char = s;code = 115
char = a;code = 97
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char = i;code = 105
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char = o;code = 111
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char = i;code = 105
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char = ;code = 32
char = b;code = 98
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char = s;code = 115
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char = p;code = 112
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char = s;code = 115
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char = o;code = 111
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result sql = Amyloid β peptide (Aβ) induced toxicity is a well-established pathway of neuronal cell death which might play a role in Alzheimer's disease. In this regard, the toxic effect of Aβ on a cultured Aβ-sensitive neuronal cell line was used as a primary screening tool for potential anti-Alzheimer's therapeutic agents. The effects of nine pure compounds (vitamin E, α-asarone, salidroside, baicolin, magnolol, gastrodin, bilobalide, honokiol and β-asarone) from selected Chinese herbs on neuronal cell death induced by Aβ in NGF-differentiated PC12 cells were examined. Only two of the studied compounds, honokiol and magnolol, significantly decreased Aβ-induced cell death. Further experiments indicated that their neuroprotective effects are possibly mediated through reduced ROS production as well as suppression of intracellular calcium elevation and inhibition of caspase-3 activity. The results provide for the first time a scientific rationale for the clinical use of honokiol and magnolol in the treatment of Alzheimer's disease.
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char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = ;code = 32
char = m;code = 109
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char = o;code = 111
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char = c;code = 99
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char = l;code = 108
char = s;code = 115
char = .;code = 46
result sql = Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells.
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result sql = Amyloid β peptide (Aβ) induced toxicity is a well-established pathway of neuronal cell death which might play a role in Alzheimer's disease. In this regard, the toxic effect of Aβ on a cultured Aβ-sensitive neuronal cell line was used as a primary screening tool for potential anti-Alzheimer's therapeutic agents. The effects of nine pure compounds (vitamin E, α-asarone, salidroside, baicolin, magnolol, gastrodin, bilobalide, honokiol and β-asarone) from selected Chinese herbs on neuronal cell death induced by Aβ in NGF-differentiated PC12 cells were examined. Only two of the studied compounds, honokiol and magnolol, significantly decreased Aβ-induced cell death. Further experiments indicated that their neuroprotective effects are possibly mediated through reduced ROS production as well as suppression of intracellular calcium elevation and inhibition of caspase-3 activity. The results provide for the first time a scientific rationale for the clinical use of honokiol and magnolol in the treatment of Alzheimer's disease.
Publication: Phytother Res 2010 Oct ;24(10)::1538-42. :doi: 10.1002/ptr.3178.
Publication Date: 2010 Oct
Study Author(s): Hoi, Chu Peng;Ho, Yee Ping;Baum, Larry;Chow, Albert H L;
Institution: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Shortcut link to this study:
Publication Date: 2010 Oct
Study Author(s): Hoi, Chu Peng;Ho, Yee Ping;Baum, Larry;Chow, Albert H L;
Institution: School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Shortcut link to this study:
Amyloid β peptide (Aβ) induced toxicity is a well-established pathway of neuronal cell death which might play a role in Alzheimer's disease. In this regard, the toxic effect of Aβ on a cultured Aβ-sensitive neuronal cell line was used as a primary screening tool for potential anti-Alzheimer's therapeutic agents. The effects of nine pure compounds (vitamin E, α-asarone, salidroside, baicolin, magnolol, gastrodin, bilobalide, honokiol and β-asarone) from selected Chinese herbs on neuronal cell death induced by Aβ in NGF-differentiated PC12 cells were examined. Only two of the studied compounds, honokiol and magnolol, significantly decreased Aβ-induced cell death. Further experiments indicated that their neuroprotective effects are possibly mediated through reduced ROS production as well as suppression of intracellular calcium elevation and inhibition of caspase-3 activity. The results provide for the first time a scientific rationale for the clinical use of honokiol and magnolol in the treatment of Alzheimer's disease.
PMID: 20878707
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