|
|
char = T;code = 84
char = h;code = 104
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char = p;code = 112
char = e;code = 101
char = f;code = 102
char = r;code = 114
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char = t;code = 116
char = :;code = 58
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char = n;code = 110
char = ;code = 32
char = o;code = 111
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char = ;code = 32
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char = ;code = 32
char = g;code = 103
char = l;code = 108
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = ?;code = 63
char = ;code = 32
char = M;code = 77
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = b;code = 98
char = o;code = 111
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char = c;code = 99
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char = i;code = 105
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char = e;code = 101
char = s;code = 115
char = .;code = 46
result sql = The grapefruit: an old wine in a new glass? Metabolic and cardiovascular perspectives.
The grapefruit: an old wine in a new glass? Metabolic and cardiovascular perspectives.char = G;code = 71
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char = a;code = 97
char = p;code = 112
char = e;code = 101
char = f;code = 102
char = r;code = 114
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char = ;code = 32
char = a;code = 97
char = ;code = 32
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char = o;code = 111
char = p;code = 112
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char = a;code = 97
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char = ;code = 32
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char = t;code = 116
char = y;code = 121
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char = ;code = 32
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char = t;code = 116
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char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = u;code = 117
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char = t;code = 116
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char = e;code = 101
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char = B;code = 66
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char = 1;code = 49
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char = a;code = 97
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char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = c;code = 99
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char = s;code = 115
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char = m;code = 109
char = p;code = 112
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = e;code = 101
char = f;code = 102
char = r;code = 114
char = u;code = 117
char = i;code = 105
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = j;code = 106
char = u;code = 117
char = i;code = 105
char = c;code = 99
char = e;code = 101
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char = i;code = 105
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char = ;code = 32
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char = s;code = 115
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char = h;code = 104
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char = d;code = 100
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char = g;code = 103
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char = e;code = 101
char = s;code = 115
char = ,;code = 44
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char = h;code = 104
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char = e;code = 101
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char = a;code = 97
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char = G;code = 71
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char = r;code = 114
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char = i;code = 105
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char = e;code = 101
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char = ;code = 32
char = a;code = 97
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char = e;code = 101
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char = q;code = 113
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char = e;code = 101
char = ;code = 32
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char = h;code = 104
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char = ;code = 32
char = t;code = 116
char = h;code = 104
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char = c;code = 99
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char = o;code = 111
char = c;code = 99
char = h;code = 104
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = e;code = 101
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char = P;code = 80
char = 4;code = 52
char = 5;code = 53
char = 0;code = 48
char = ;code = 32
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char = z;code = 122
char = y;code = 121
char = m;code = 109
char = e;code = 101
char = ;code = 32
char = C;code = 67
char = Y;code = 89
char = P;code = 80
char = 3;code = 51
char = A;code = 65
char = 4;code = 52
char = ,;code = 44
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char = w;code = 119
char = h;code = 104
char = i;code = 105
char = c;code = 99
char = h;code = 104
char = ;code = 32
char = m;code = 109
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char = t;code = 116
char = a;code = 97
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char = e;code = 101
char = s;code = 115
char = ;code = 32
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char = e;code = 101
char = r;code = 114
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char = 6;code = 54
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char = %;code = 37
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char = m;code = 109
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char = r;code = 114
char = i;code = 105
char = b;code = 98
char = e;code = 101
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char = d;code = 100
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char = g;code = 103
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = d;code = 100
char = r;code = 114
char = u;code = 117
char = g;code = 103
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = s;code = 115
char = p;code = 112
char = o;code = 111
char = r;code = 114
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char = e;code = 101
char = r;code = 114
char = ;code = 32
char = p;code = 112
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char = t;code = 116
char = e;code = 101
char = i;code = 105
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char = s;code = 115
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = c;code = 99
char = h;code = 104
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = P;code = 80
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char = I;code = 73
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char = g;code = 103
char = e;code = 101
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char = e;code = 101
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char = a;code = 97
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char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = s;code = 115
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char = s;code = 115
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char = c;code = 99
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char = d;code = 100
char = i;code = 105
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char = e;code = 101
char = s;code = 115
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char = a;code = 97
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char = a;code = 97
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char = u;code = 117
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char = d;code = 100
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char = o;code = 111
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char = d;code = 100
char = e;code = 101
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char = T;code = 84
char = h;code = 104
char = i;code = 105
char = s;code = 115
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char = o;code = 111
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char = e;code = 101
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char = t;code = 116
char = i;code = 105
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char = l;code = 108
char = y;code = 121
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char = x;code = 120
char = p;code = 112
char = l;code = 108
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = j;code = 106
char = e;code = 101
char = c;code = 99
char = t;code = 116
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char = i;code = 105
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = v;code = 118
char = i;code = 105
char = e;code = 101
char = w;code = 119
char = e;code = 101
char = d;code = 100
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char = h;code = 104
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = Grapefruit is a popular, tasty and nutritive fruit enjoyed globally. Biomedical evidence in the last 10 years has, however, shown that consumption of grapefruit or its juice is associated with drug interactions, which, in some cases, have been fatal. Grapefruit-induced drug interactions are unique in that the cytochrome P450 enzyme CYP3A4, which metabolises over 60% of commonly prescribed drugs as well as other drug transporter proteins such as P-glycoprotein and organic cation transporter proteins, which are all expressed in the intestines, are involved. However, the extent to which grapefruit-drug interactions impact on clinical settings has not been fully determined, probably because many cases are not reported. It has recently emerged that grapefruit, by virtue of its rich flavonoid content, is beneficial in the management of degenerative diseases such as diabetes and cardiovascular disorders. This potentially explosive subject is reviewed here.
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = e;code = 101
char = f;code = 102
char = r;code = 114
char = u;code = 117
char = i;code = 105
char = t;code = 116
char = :;code = 58
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = l;code = 108
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = n;code = 110
char = e;code = 101
char = w;code = 119
char = ;code = 32
char = g;code = 103
char = l;code = 108
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = ?;code = 63
char = ;code = 32
char = M;code = 77
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = b;code = 98
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = d;code = 100
char = i;code = 105
char = o;code = 111
char = v;code = 118
char = a;code = 97
char = s;code = 115
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = s;code = 115
char = .;code = 46
result sql = The grapefruit: an old wine in a new glass? Metabolic and cardiovascular perspectives.
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char = p;code = 112
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char = f;code = 102
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char = t;code = 116
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char = i;code = 105
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char = ,;code = 44
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char = i;code = 105
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char = l;code = 108
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char = B;code = 66
char = i;code = 105
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char = s;code = 115
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char = o;code = 111
char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = a;code = 97
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char = c;code = 99
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char = s;code = 115
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char = m;code = 109
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char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
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char = ;code = 32
char = g;code = 103
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char = a;code = 97
char = p;code = 112
char = e;code = 101
char = f;code = 102
char = r;code = 114
char = u;code = 117
char = i;code = 105
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = t;code = 116
char = s;code = 115
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char = j;code = 106
char = u;code = 117
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char = a;code = 97
char = c;code = 99
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char = G;code = 71
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char = q;code = 113
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char = a;code = 97
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char = h;code = 104
char = e;code = 101
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char = c;code = 99
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char = y;code = 121
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char = e;code = 101
char = ;code = 32
char = C;code = 67
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char = P;code = 80
char = 3;code = 51
char = A;code = 65
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char = a;code = 97
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char = 6;code = 54
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char = %;code = 37
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char = h;code = 104
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result sql = Grapefruit is a popular, tasty and nutritive fruit enjoyed globally. Biomedical evidence in the last 10 years has, however, shown that consumption of grapefruit or its juice is associated with drug interactions, which, in some cases, have been fatal. Grapefruit-induced drug interactions are unique in that the cytochrome P450 enzyme CYP3A4, which metabolises over 60% of commonly prescribed drugs as well as other drug transporter proteins such as P-glycoprotein and organic cation transporter proteins, which are all expressed in the intestines, are involved. However, the extent to which grapefruit-drug interactions impact on clinical settings has not been fully determined, probably because many cases are not reported. It has recently emerged that grapefruit, by virtue of its rich flavonoid content, is beneficial in the management of degenerative diseases such as diabetes and cardiovascular disorders. This potentially explosive subject is reviewed here.
Publication: Cardiovasc J Afr 2010 Sep-Oct ;21(5)::280-5.
Publication Date: 2010 Sep-Oct
Study Author(s): Owira, P M;Ojewole, J A;
Institution: Department of Pharmacology, University of KwaZulu-Natal, Durban, South Africa. [email protected]
Shortcut link to this study:
Publication Date: 2010 Sep-Oct
Study Author(s): Owira, P M;Ojewole, J A;
Institution: Department of Pharmacology, University of KwaZulu-Natal, Durban, South Africa. [email protected]
Shortcut link to this study:
Grapefruit is a popular, tasty and nutritive fruit enjoyed globally. Biomedical evidence in the last 10 years has, however, shown that consumption of grapefruit or its juice is associated with drug interactions, which, in some cases, have been fatal. Grapefruit-induced drug interactions are unique in that the cytochrome P450 enzyme CYP3A4, which metabolises over 60% of commonly prescribed drugs as well as other drug transporter proteins such as P-glycoprotein and organic cation transporter proteins, which are all expressed in the intestines, are involved. However, the extent to which grapefruit-drug interactions impact on clinical settings has not been fully determined, probably because many cases are not reported. It has recently emerged that grapefruit, by virtue of its rich flavonoid content, is beneficial in the management of degenerative diseases such as diabetes and cardiovascular disorders. This potentially explosive subject is reviewed here.
PMID: 20972517
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