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char = a;code = 97
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char = t;code = 116
char = r;code = 114
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char = e;code = 101
char = s;code = 115
char = o;code = 111
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char = e;code = 101
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = f;code = 102
char = l;code = 108
char = a;code = 97
char = p;code = 112
char = ;code = 32
char = v;code = 118
char = a;code = 97
char = l;code = 108
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = u;code = 117
char = s;code = 115
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = u;code = 117
char = i;code = 105
char = s;code = 115
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = c;code = 99
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = p;code = 112
char = h;code = 104
char = e;code = 101
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = y;code = 121
char = p;code = 112
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = n;code = 110
char = i;code = 105
char = a;code = 97
char = .;code = 46
result sql = Gastroesophageal flap valve status distinguishes clinical phenotypes of large hiatal hernia.

Gastroesophageal flap valve status distinguishes clinical phenotypes of large hiatal hernia.

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char = g;code = 103
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char = l;code = 108
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char = ;code = 32
char = (;code = 40
char = C;code = 67
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char = m;code = 109
char = e;code = 101
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char = l;code = 108
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char = i;code = 105
char = o;code = 111
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char = s;code = 115
char = );code = 41
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = p;code = 112
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char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = n;code = 110
char = i;code = 105
char = a;code = 97
char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = M;code = 77
char = E;code = 69
char = T;code = 84
char = H;code = 72
char = O;code = 79
char = D;code = 68
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
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char = >;code = 62
char = A;code = 65
char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = e;code = 101
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char = s;code = 115
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = y;code = 121
char = ;code = 32
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char = a;code = 97
char = s;code = 115
char = ;code = 32
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char = e;code = 101
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char = f;code = 102
char = o;code = 111
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char = e;code = 101
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char = w;code = 119
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char = h;code = 104
char = ;code = 32
char = 1;code = 49
char = 6;code = 54
char = ;code = 32
char = 8;code = 56
char = 3;code = 51
char = 1;code = 49
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
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char = t;code = 116
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = h;code = 104
char = o;code = 111
char = ;code = 32
char = u;code = 117
char = n;code = 110
char = d;code = 100
char = e;code = 101
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char = w;code = 119
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char = d;code = 100
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char = a;code = 97
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char = f;code = 102
char = e;code = 101
char = r;code = 114
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = .;code = 46
char = ;code = 32
char = A;code = 65
char = ;code = 32
char = h;code = 104
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char = a;code = 97
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char = u;code = 117
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char = e;code = 101
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char = &;code = 38
char = #;code = 35
char = 8;code = 56
char = 8;code = 56
char = 0;code = 48
char = 5;code = 53
char = ;;code = 59
char = ;code = 32
char = 4;code = 52
char = ;code = 32
char = c;code = 99
char = m;code = 109
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = f;code = 102
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = n;code = 110
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char = a;code = 97
char = .;code = 46
char = ;code = 32
char = A;code = 65
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char = s;code = 115
char = h;code = 104
char = a;code = 97
char = r;code = 114
char = p;code = 112
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = l;code = 108
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = s;code = 115
char = u;code = 117
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char = r;code = 114
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char = ;code = 32
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char = ;code = 32
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char = ;code = 32
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char = (;code = 40
char = G;code = 71
char = E;code = 69
char = F;code = 70
char = V;code = 86
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char = ,;code = 44
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char = ;code = 32
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char = S;code = 83
char = U;code = 85
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char = 4;code = 52
char = 9;code = 57
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char = 1;code = 49
char = 6;code = 54
char = ,;code = 44
char = 8;code = 56
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char = e;code = 101
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char = t;code = 116
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = C;code = 67
char = a;code = 97
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char = e;code = 101
char = r;code = 114
char = o;code = 111
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char = s;code = 115
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char = ;code = 32
char = r;code = 114
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char = f;code = 102
char = l;code = 108
char = u;code = 117
char = x;code = 120
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char = e;code = 101
char = s;code = 115
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char = p;code = 112
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char = a;code = 97
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char = i;code = 105
char = t;code = 116
char = i;code = 105
char = s;code = 115
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char = w;code = 119
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char = r;code = 114
char = e;code = 101
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char = i;code = 105
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char = 1;code = 49
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char = %;code = 37
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = 4;code = 52
char = 7;code = 55
char = %;code = 37
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
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char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
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char = ;code = 32
char = a;code = 97
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char = 0;code = 48
char = %;code = 37
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = 8;code = 56
char = %;code = 37
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
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char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = o;code = 111
char = u;code = 117
char = t;code = 116
char = ;code = 32
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
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char = h;code = 104
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = a;code = 97
char = l;code = 108
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char = h;code = 104
char = e;code = 101
char = r;code = 114
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char = i;code = 105
char = a;code = 97
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = h;code = 104
char = i;code = 105
char = c;code = 99
char = h;code = 104
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = g;code = 103
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = t;code = 116
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char = a;code = 97
char = s;code = 115
char = s;code = 115
char = o;code = 111
char = c;code = 99
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = t;code = 116
char = w;code = 119
char = e;code = 101
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = n;code = 110
char = i;code = 105
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
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char = d;code = 100
char = i;code = 105
char = s;code = 115
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = H;code = 72
char = o;code = 111
char = w;code = 119
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = n;code = 110
char = o;code = 111
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char = c;code = 99
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char = c;code = 99
char = i;code = 105
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char = e;code = 101
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char = c;code = 99
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = t;code = 116
char = w;code = 119
char = o;code = 111
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char = d;code = 100
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = n;code = 110
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char = i;code = 105
char = s;code = 115
char = o;code = 111
char = r;code = 114
char = d;code = 100
char = e;code = 101
char = r;code = 114
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char = .;code = 46
char = ;code = 32
char = U;code = 85
char = n;code = 110
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char = v;code = 118
char = a;code = 97
char = r;code = 114
char = i;code = 105
char = a;code = 97
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char = e;code = 101
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char = a;code = 97
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char = a;code = 97
char = l;code = 108
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char = e;code = 101
char = m;code = 109
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char = s;code = 115
char = t;code = 116
char = r;code = 114
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = s;code = 115
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char = g;code = 103
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char = f;code = 102
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char = c;code = 99
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char = a;code = 97
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char = r;code = 114
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char = s;code = 115
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char = n;code = 110
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char = ;code = 32
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char = t;code = 116
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char = i;code = 105
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char = l;code = 108
char = a;code = 97
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char = m;code = 109
char = a;code = 97
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char = o;code = 111
char = r;code = 114
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char = d;code = 100
char = r;code = 114
char = u;code = 117
char = g;code = 103
char = ;code = 32
char = (;code = 40
char = N;code = 78
char = S;code = 83
char = A;code = 65
char = I;code = 73
char = D;code = 68
char = );code = 41
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = t;code = 116
char = a;code = 97
char = k;code = 107
char = e;code = 101
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char = (;code = 40
char = 8;code = 56
char = 0;code = 48
char = %;code = 37
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char = i;code = 105
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char = C;code = 67
char = a;code = 97
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char = e;code = 101
char = r;code = 114
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char = e;code = 101
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char = i;code = 105
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char = e;code = 101
char = s;code = 115
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char = v;code = 118
char = s;code = 115
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char = 1;code = 49
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char = %;code = 37
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = n;code = 110
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char = n;code = 110
char = -;code = 45
char = C;code = 67
char = a;code = 97
char = m;code = 109
char = e;code = 101
char = r;code = 114
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char = n;code = 110
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char = l;code = 108
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = o;code = 111
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char = a;code = 97
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char = e;code = 101
char = s;code = 115
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char = ;code = 32
char = P;code = 80
char = ;code = 32
char = =;code = 61
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char = .;code = 46
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char = 1;code = 49
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = i;code = 105
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char = t;code = 116
char = a;code = 97
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char = t;code = 116
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char = G;code = 71
char = E;code = 69
char = F;code = 70
char = V;code = 86
char = ;code = 32
char = (;code = 40
char = 1;code = 49
char = 0;code = 48
char = 0;code = 48
char = %;code = 37
char = ;code = 32
char = i;code = 105
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char = C;code = 67
char = a;code = 97
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char = e;code = 101
char = r;code = 114
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char = e;code = 101
char = s;code = 115
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char = o;code = 111
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char = ;code = 32
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char = a;code = 97
char = s;code = 115
char = e;code = 101
char = s;code = 115
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char = v;code = 118
char = s;code = 115
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char = 1;code = 49
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char = %;code = 37
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char = o;code = 111
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char = e;code = 101
char = r;code = 114
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char = e;code = 101
char = s;code = 115
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char = ;code = 32
char = P;code = 80
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char = 0;code = 48
char = 0;code = 48
char = 0;code = 48
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char = .;code = 46
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char = I;code = 73
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char = c;code = 99
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char = t;code = 116
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char = a;code = 97
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char = f;code = 102
char = l;code = 108
char = u;code = 117
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char = p;code = 112
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char = a;code = 97
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char = s;code = 115
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char = a;code = 97
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char = e;code = 101
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char = t;code = 116
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char = i;code = 105
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char = p;code = 112
char = a;code = 97
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char = r;code = 114
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char = d;code = 100
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char = G;code = 71
char = E;code = 69
char = F;code = 70
char = V;code = 86
char = ;code = 32
char = (;code = 40
char = 4;code = 52
char = 4;code = 52
char = %;code = 37
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char = i;code = 105
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char = f;code = 102
char = l;code = 108
char = u;code = 117
char = x;code = 120
char = ;code = 32
char = e;code = 101
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char = o;code = 111
char = p;code = 112
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char = a;code = 97
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char = t;code = 116
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char = s;code = 115
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char = c;code = 99
char = a;code = 97
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char = e;code = 101
char = s;code = 115
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char = v;code = 118
char = s;code = 115
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char = 8;code = 56
char = %;code = 37
char = ;code = 32
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char = ;code = 32
char = e;code = 101
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char = o;code = 111
char = p;code = 112
char = h;code = 104
char = a;code = 97
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char = i;code = 105
char = t;code = 116
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char = c;code = 99
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = P;code = 80
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 1;code = 49
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char = .;code = 46
char = ;code = 32
char = M;code = 77
char = u;code = 117
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char = t;code = 116
char = i;code = 105
char = v;code = 118
char = a;code = 97
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char = a;code = 97
char = t;code = 116
char = e;code = 101
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char = e;code = 101
char = g;code = 103
char = r;code = 114
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char = s;code = 115
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char = o;code = 111
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char = a;code = 97
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char = y;code = 121
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char = i;code = 105
char = s;code = 115
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char = c;code = 99
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char = n;code = 110
char = f;code = 102
char = i;code = 105
char = r;code = 114
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char = e;code = 101
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = i;code = 105
char = g;code = 103
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char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = t;code = 116
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char = a;code = 97
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char = o;code = 111
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char = i;code = 105
char = a;code = 97
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char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
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char = <;code = 60
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char = ;code = 32
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char = e;code = 101
char = ;code = 32
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char = ;code = 32
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char = e;code = 101
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = ;code = 32
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char = s;code = 115
char = s;code = 115
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char = e;code = 101
char = d;code = 100
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = i;code = 105
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char = t;code = 116
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char = c;code = 99
char = t;code = 116
char = ;code = 32
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char = E;code = 69
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char = V;code = 86
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
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char = S;code = 83
char = A;code = 65
char = I;code = 73
char = D;code = 68
char = ;code = 32
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result sql = AIM : To investigate two distinct clinical phenotypes of reflux esophagitis and intra-hernial ulcer (Cameron lesions) in patients with large hiatal hernias.

METHODS : A case series study was performed with 16 831 patients who underwent diagnostic esophagogastroduodenoscopy for 2 years at an academic referral center. A hiatus diameter ≥ 4 cm was defined as a large hernia. A sharp fold that surrounded the cardia was designated as an intact gastroesophageal flap valve (GEFV), and a loose fold or disappearance of the fold was classified as an impaired GEFV. We studied the associations between large hiatal hernias and the distinct clinical phenotypes (reflux esophagitis and Cameron lesions), and analyzed factors that distinguished the clinical phenotypes.

RESULTS : Large hiatal hernias were found in 49 (0.3%) of 16,831 patients. Cameron lesions and reflux esophagitis were observed in 10% and 47% of these patients, and 0% and 8% of the patients without large hiatal hernias, which indicated significant associations between large hiatal hernias and these diseases. However, there was no coincidence of the two distinct disorders. Univariate analysis demonstrated significant associations between Cameron lesions and the clinico-endoscopic factors such as nonsteroidal anti-inflammatory drug (NSAID) intake (80% in Cameron lesion cases vs 18% in non-Cameron lesion cases, P = 0.015) and intact GEFV (100% in Cameron lesion cases vs 18% in non-Cameron lesion cases, P = 0.0007). In contrast, reflux esophagitis was linked with impaired GEFV (44% in reflux esophagitis cases vs 8% in non-reflux esophagitis cases, P = 0.01). Multivariate regression analysis confirmed these significant associations.

CONCLUSION : GEFV status and NSAID intake distinguish clinical phenotypes of large hiatal hernias. Cameron lesions are associated with intact GEFV and NSAID intake.

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