|
|
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result sql = Effects of ferulic acid on hematopoietic cell recovery in whole-body gamma irradiated mice.
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result sql = PURPOSE : The objective of this study was to investigate the mechanism for ferulic acid (FA)-induced radioprotection by evaluating the recovery of bone marrow cells and peripheral blood hematology.
MATERIALS AND METHODS : Balb/c mice were irradiated at a dose of 2.5 Gy using cobalt-60 gamma resources. Following irradiation, FA was administered intragastrically for seven consecutive days. Hematopoietic progenitor colony-forming cell assays were used to assess the reconstitution of bone marrow after radiation-induced myelosuppression. Cytokine levels were investigated using enzyme-linked immunosorbent assay and Western blot analysis.
RESULTS : The results demonstrated that FA treatment enhanced hematopoietic progenitor cell activity resulting in accelerated blood cell recovery. FA administration increased levels of granulocyte-colony stimulating factor (G-CSF) and erythropoietin.
CONCLUSION : These results suggest radioprotective efficacy by FA may be a result of early recovery of hematopoietic cells due to enhanced production of G-CSF and erythropoietin.
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result sql = Effects of ferulic acid on hematopoietic cell recovery in whole-body gamma irradiated mice.
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char = l;code = 108
char = o;code = 111
char = c;code = 99
char = y;code = 121
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char = e;code = 101
char = -;code = 45
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char = <;code = 60
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char = d;code = 100
char = ;code = 32
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char = r;code = 114
char = y;code = 121
char = t;code = 116
char = h;code = 104
char = r;code = 114
char = o;code = 111
char = p;code = 112
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result sql = PURPOSE : The objective of this study was to investigate the mechanism for ferulic acid (FA)-induced radioprotection by evaluating the recovery of bone marrow cells and peripheral blood hematology.
MATERIALS AND METHODS : Balb/c mice were irradiated at a dose of 2.5 Gy using cobalt-60 gamma resources. Following irradiation, FA was administered intragastrically for seven consecutive days. Hematopoietic progenitor colony-forming cell assays were used to assess the reconstitution of bone marrow after radiation-induced myelosuppression. Cytokine levels were investigated using enzyme-linked immunosorbent assay and Western blot analysis.
RESULTS : The results demonstrated that FA treatment enhanced hematopoietic progenitor cell activity resulting in accelerated blood cell recovery. FA administration increased levels of granulocyte-colony stimulating factor (G-CSF) and erythropoietin.
CONCLUSION : These results suggest radioprotective efficacy by FA may be a result of early recovery of hematopoietic cells due to enhanced production of G-CSF and erythropoietin.
Publication: Int. J. Radiat. Biol. 2011 May ;87(5)::499-505. :doi: 10.3109/09553002.2011.548438.
Publication Date: 2011 May
Study Author(s): Ma, Zeng-Chun;Hong, Qian;Wang, Yu-Guang;Tan, Hong-Ling;Xiao, Cheng-Rong;Liang, Qian-De;Lu, Bei-Bei;Gao, Yue;
Institution: Beijing Institute of Radiation Medicine, Tai-Ping Road 27, Beijing, P. R. China.
Shortcut link to this study:
Publication Date: 2011 May
Study Author(s): Ma, Zeng-Chun;Hong, Qian;Wang, Yu-Guang;Tan, Hong-Ling;Xiao, Cheng-Rong;Liang, Qian-De;Lu, Bei-Bei;Gao, Yue;
Institution: Beijing Institute of Radiation Medicine, Tai-Ping Road 27, Beijing, P. R. China.
Shortcut link to this study:
PURPOSE : The objective of this study was to investigate the mechanism for ferulic acid (FA)-induced radioprotection by evaluating the recovery of bone marrow cells and peripheral blood hematology.
MATERIALS AND METHODS : Balb/c mice were irradiated at a dose of 2.5 Gy using cobalt-60 gamma resources. Following irradiation, FA was administered intragastrically for seven consecutive days. Hematopoietic progenitor colony-forming cell assays were used to assess the reconstitution of bone marrow after radiation-induced myelosuppression. Cytokine levels were investigated using enzyme-linked immunosorbent assay and Western blot analysis.
RESULTS : The results demonstrated that FA treatment enhanced hematopoietic progenitor cell activity resulting in accelerated blood cell recovery. FA administration increased levels of granulocyte-colony stimulating factor (G-CSF) and erythropoietin.
CONCLUSION : These results suggest radioprotective efficacy by FA may be a result of early recovery of hematopoietic cells due to enhanced production of G-CSF and erythropoietin.
MATERIALS AND METHODS : Balb/c mice were irradiated at a dose of 2.5 Gy using cobalt-60 gamma resources. Following irradiation, FA was administered intragastrically for seven consecutive days. Hematopoietic progenitor colony-forming cell assays were used to assess the reconstitution of bone marrow after radiation-induced myelosuppression. Cytokine levels were investigated using enzyme-linked immunosorbent assay and Western blot analysis.
RESULTS : The results demonstrated that FA treatment enhanced hematopoietic progenitor cell activity resulting in accelerated blood cell recovery. FA administration increased levels of granulocyte-colony stimulating factor (G-CSF) and erythropoietin.
CONCLUSION : These results suggest radioprotective efficacy by FA may be a result of early recovery of hematopoietic cells due to enhanced production of G-CSF and erythropoietin.
PMID: 21254928
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