|
|
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char = t;code = 116
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = C;code = 67
char = .;code = 46
result sql = Iron levels in hepatocytes and portal tract cells predict progression and outcomes of patients with advanced chronic hepatitis C.
Iron levels in hepatocytes and portal tract cells predict progression and outcomes of patients with advanced chronic hepatitis C.char = <;code = 60
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char = H;code = 72
char = C;code = 67
char = C;code = 67
char = ,;code = 44
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char = d;code = 100
char = e;code = 101
char = a;code = 97
char = t;code = 116
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char = h;code = 104
char = a;code = 97
char = d;code = 100
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char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = t;code = 116
char = l;code = 108
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char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = e;code = 101
char = r;code = 114
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char = b;code = 98
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = l;code = 108
char = i;code = 105
char = n;code = 110
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char = s;code = 115
char = c;code = 99
char = o;code = 111
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char = e;code = 101
char = s;code = 115
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = s;code = 115
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char = a;code = 97
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char = n;code = 110
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
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char = i;code = 105
char = r;code = 114
char = o;code = 111
char = n;code = 110
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = e;code = 101
char = s;code = 115
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = r;code = 114
char = t;code = 116
char = a;code = 97
char = l;code = 108
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char = t;code = 116
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
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char = t;code = 116
char = h;code = 104
char = a;code = 97
char = n;code = 110
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char = t;code = 116
char = h;code = 104
char = o;code = 111
char = s;code = 115
char = e;code = 101
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char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = o;code = 111
char = u;code = 117
char = t;code = 116
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = w;code = 119
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char = r;code = 114
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = g;code = 103
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = t;code = 116
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char = d;code = 100
char = i;code = 105
char = r;code = 114
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = r;code = 114
char = r;code = 114
char = e;code = 101
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = t;code = 116
char = w;code = 119
char = e;code = 101
char = e;code = 101
char = n;code = 110
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char = s;code = 115
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char = a;code = 97
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char = n;code = 110
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
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char = i;code = 105
char = r;code = 114
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = r;code = 114
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = a;code = 97
char = d;code = 100
char = s;code = 115
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = l;code = 108
char = o;code = 111
char = b;code = 98
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = I;code = 73
char = s;code = 115
char = h;code = 104
char = a;code = 97
char = k;code = 107
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = f;code = 102
char = l;code = 108
char = a;code = 97
char = m;code = 109
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = y;code = 121
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = i;code = 105
char = b;code = 98
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = c;code = 99
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = s;code = 115
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char = [;code = 91
char = P;code = 80
char = ;code = 32
char = <;code = 60
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char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 0;code = 48
char = 0;code = 48
char = 1;code = 49
char = ];code = 93
char = .;code = 46
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char = I;code = 73
char = r;code = 114
char = o;code = 111
char = n;code = 110
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = a;code = 97
char = d;code = 100
char = s;code = 115
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char = a;code = 97
char = t;code = 116
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char = b;code = 98
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = c;code = 99
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = r;code = 114
char = i;code = 105
char = s;code = 115
char = k;code = 107
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = o;code = 111
char = u;code = 117
char = t;code = 116
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = H;code = 72
char = R;code = 82
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 1;code = 49
char = .;code = 46
char = 3;code = 51
char = 5;code = 53
char = ,;code = 44
char = ;code = 32
char = P;code = 80
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 2;code = 50
char = );code = 41
char = .;code = 46
char = ;code = 32
char = S;code = 83
char = t;code = 116
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = r;code = 114
char = o;code = 111
char = n;code = 110
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char = i;code = 105
char = n;code = 110
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char = h;code = 104
char = e;code = 101
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char = a;code = 97
char = t;code = 116
char = o;code = 111
char = c;code = 99
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char = e;code = 101
char = s;code = 115
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char = d;code = 100
char = e;code = 101
char = c;code = 99
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char = d;code = 100
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char = w;code = 119
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char = r;code = 114
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char = a;code = 97
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char = t;code = 116
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char = a;code = 97
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char = a;code = 97
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char = r;code = 114
char = o;code = 111
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char = a;code = 97
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char = c;code = 99
char = e;code = 101
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char = l;code = 108
char = s;code = 115
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char = i;code = 105
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char = c;code = 99
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char = a;code = 97
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char = e;code = 101
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char = s;code = 115
char = i;code = 105
char = g;code = 103
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char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = l;code = 108
char = y;code = 121
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char = [;code = 91
char = P;code = 80
char = ;code = 32
char = <;code = 60
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 0;code = 48
char = 0;code = 48
char = 1;code = 49
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char = o;code = 111
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char = e;code = 101
char = r;code = 114
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char = t;code = 116
char = i;code = 105
char = m;code = 109
char = e;code = 101
char = .;code = 46
char = ;code = 32
char = S;code = 83
char = e;code = 101
char = r;code = 114
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = i;code = 105
char = r;code = 114
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = T;code = 84
char = I;code = 73
char = B;code = 66
char = C;code = 67
char = ;code = 32
char = f;code = 102
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = g;code = 103
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = t;code = 116
char = l;code = 108
char = y;code = 121
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char = o;code = 111
char = v;code = 118
char = e;code = 101
char = r;code = 114
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char = t;code = 116
char = i;code = 105
char = m;code = 109
char = e;code = 101
char = ;code = 32
char = [;code = 91
char = P;code = 80
char = ;code = 32
char = <;code = 60
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 0;code = 48
char = 0;code = 48
char = 1;code = 49
char = ];code = 93
char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = r;code = 114
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = r;code = 114
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = [;code = 91
char = P;code = 80
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 0;code = 48
char = 0;code = 48
char = 3;code = 51
char = ];code = 93
char = .;code = 46
char = ;code = 32
char = C;code = 67
char = h;code = 104
char = r;code = 114
char = o;code = 111
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = P;code = 80
char = e;code = 101
char = g;code = 103
char = I;code = 73
char = F;code = 70
char = N;code = 78
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = m;code = 109
char = e;code = 101
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char = ;code = 32
char = d;code = 100
char = i;code = 105
char = d;code = 100
char = ;code = 32
char = n;code = 110
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char = ;code = 32
char = a;code = 97
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = ;code = 32
char = s;code = 115
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char = a;code = 97
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char = n;code = 110
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
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char = i;code = 105
char = r;code = 114
char = o;code = 111
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char = .;code = 46
char = ;code = 32
char = H;code = 72
char = F;code = 70
char = E;code = 69
char = ;code = 32
char = g;code = 103
char = e;code = 101
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char = e;code = 101
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char = i;code = 105
char = c;code = 99
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char = v;code = 118
char = a;code = 97
char = r;code = 114
char = i;code = 105
char = a;code = 97
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char = o;code = 111
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char = s;code = 115
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char = i;code = 105
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char = r;code = 114
char = e;code = 101
char = l;code = 108
char = a;code = 97
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char = e;code = 101
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char = m;code = 109
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char = s;code = 115
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char = c;code = 99
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char = u;code = 117
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char = p;code = 112
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char = e;code = 101
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char = a;code = 97
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char = l;code = 108
char = u;code = 117
char = l;code = 108
char = a;code = 97
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char = c;code = 99
char = a;code = 97
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char = c;code = 99
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char = n;code = 110
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char = m;code = 109
char = a;code = 97
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
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char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = C;code = 67
char = O;code = 79
char = N;code = 78
char = C;code = 67
char = L;code = 76
char = U;code = 85
char = S;code = 83
char = I;code = 73
char = O;code = 79
char = N;code = 78
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = S;code = 83
char = t;code = 116
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = a;code = 97
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char = l;code = 108
char = e;code = 101
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char = r;code = 114
char = o;code = 111
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char = i;code = 105
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char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
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char = o;code = 111
char = c;code = 99
char = y;code = 121
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char = a;code = 97
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char = a;code = 97
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char = t;code = 116
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char = c;code = 99
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char = l;code = 108
char = l;code = 108
char = s;code = 115
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char = ;code = 32
char = a;code = 97
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char = p;code = 112
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = i;code = 105
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char = t;code = 116
char = o;code = 111
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = g;code = 103
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char = e;code = 101
char = s;code = 115
char = s;code = 115
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char = o;code = 111
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char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = l;code = 108
char = i;code = 105
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char = c;code = 99
char = a;code = 97
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char = a;code = 97
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char = d;code = 100
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char = h;code = 104
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = o;code = 111
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char = o;code = 111
char = g;code = 103
char = i;code = 105
char = c;code = 99
char = a;code = 97
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char = ;code = 32
char = o;code = 111
char = u;code = 117
char = t;code = 116
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = e;code = 101
char = s;code = 115
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char = i;code = 105
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char = a;code = 97
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char = v;code = 118
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
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result sql = BACKGROUND & AIMS : Iron may influence severity and progression of non-hemochromatotic liver diseases. Our aim was to assess the relationship of iron and HFE genetic variations to progression and outcomes in the HALT-C Trial and whether PegIFN therapy influenced iron variables.
METHODS : Participants were randomized to receive long-term PegIFN [n = 400] or no therapy [n = 413] for 3.5 y, with follow-up for up to 8.7 y [median 6.0 y]. Associations of patient characteristics with iron variables at baseline and over time were carried out using Kaplan-Meier analyses, Cox regression models, and repeated measures analysis of covariance.
RESULTS : Participants who developed clinical outcomes [CTP > 7, ascites, encephalopathy, variceal bleeding, SBP, HCC, death] had significantly higher baseline scores for stainable iron in hepatocytes and in portal tract cells than those without. There were significant direct correlations between stainable iron in portal triads and lobular and total Ishak inflammatory and fibrosis scores [P < 0.0001]. Iron in triads at baseline increased risk of outcomes (HR = 1.35, P = 0.02). Stainable iron in hepatocytes decreased, whereas that in portal stromal cells increased significantly [P < 0.0001] over time. Serum iron and TIBC fell significantly over time [P < 0.0001], as did serum ferritin [P = 0.0003]. Chronic PegIFN treatment did not affect stainable iron. HFE genetic variations did not correlate with outcomes, including development of hepatocellular carcinoma.
CONCLUSIONS : Stainable iron in hepatocytes and portal tract cells is a predictor of progression and clinical and histological outcomes in advanced chronic hepatitis C. Chronic low-dose PegIFN therapy did not improve outcomes, nor iron variables.
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result sql = Iron levels in hepatocytes and portal tract cells predict progression and outcomes of patients with advanced chronic hepatitis C.
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char = <;code = 60
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char = <;code = 60
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char = >;code = 62
char = R;code = 82
char = E;code = 69
char = S;code = 83
char = U;code = 85
char = L;code = 76
char = T;code = 84
char = S;code = 83
char = ;code = 32
char = :;code = 58
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char = <;code = 60
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char = >;code = 62
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char = a;code = 97
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char = c;code = 99
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char = t;code = 116
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char = o;code = 111
char = m;code = 109
char = e;code = 101
char = s;code = 115
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char = [;code = 91
char = C;code = 67
char = T;code = 84
char = P;code = 80
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char = >;code = 62
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char = 7;code = 55
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char = s;code = 115
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char = e;code = 101
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char = a;code = 97
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char = a;code = 97
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char = b;code = 98
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char = e;code = 101
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char = S;code = 83
char = B;code = 66
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char = H;code = 72
char = C;code = 67
char = C;code = 67
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char = d;code = 100
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char = a;code = 97
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char = a;code = 97
char = d;code = 100
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char = s;code = 115
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char = g;code = 103
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char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = l;code = 108
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char = h;code = 104
char = i;code = 105
char = g;code = 103
char = h;code = 104
char = e;code = 101
char = r;code = 114
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char = b;code = 98
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = l;code = 108
char = i;code = 105
char = n;code = 110
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char = s;code = 115
char = c;code = 99
char = o;code = 111
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char = s;code = 115
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char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = s;code = 115
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char = a;code = 97
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char = n;code = 110
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
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char = i;code = 105
char = r;code = 114
char = o;code = 111
char = n;code = 110
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char = i;code = 105
char = n;code = 110
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char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
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char = o;code = 111
char = c;code = 99
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char = e;code = 101
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char = a;code = 97
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char = i;code = 105
char = n;code = 110
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char = o;code = 111
char = r;code = 114
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char = a;code = 97
char = l;code = 108
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = c;code = 99
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
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char = t;code = 116
char = h;code = 104
char = a;code = 97
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char = t;code = 116
char = h;code = 104
char = o;code = 111
char = s;code = 115
char = e;code = 101
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = o;code = 111
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char = t;code = 116
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = e;code = 101
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char = w;code = 119
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char = r;code = 114
char = e;code = 101
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char = s;code = 115
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char = g;code = 103
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char = f;code = 102
char = i;code = 105
char = c;code = 99
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char = c;code = 99
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char = c;code = 99
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char = r;code = 114
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char = a;code = 97
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char = s;code = 115
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char = a;code = 97
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char = i;code = 105
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char = r;code = 114
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char = t;code = 116
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char = a;code = 97
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char = I;code = 73
char = s;code = 115
char = h;code = 104
char = a;code = 97
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char = 0;code = 48
char = 0;code = 48
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char = H;code = 72
char = R;code = 82
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char = 1;code = 49
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char = 3;code = 51
char = 5;code = 53
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char = P;code = 80
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char = 0;code = 48
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char = 0;code = 48
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char = .;code = 46
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char = S;code = 83
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char = P;code = 80
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char = <;code = 60
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char = 0;code = 48
char = 0;code = 48
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char = S;code = 83
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char = T;code = 84
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char = C;code = 67
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char = f;code = 102
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char = 0;code = 48
char = 0;code = 48
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char = a;code = 97
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char = <;code = 60
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char = C;code = 67
char = O;code = 79
char = N;code = 78
char = C;code = 67
char = L;code = 76
char = U;code = 85
char = S;code = 83
char = I;code = 73
char = O;code = 79
char = N;code = 78
char = S;code = 83
char = ;code = 32
char = :;code = 58
char = ;code = 32
char = <;code = 60
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result sql = BACKGROUND & AIMS : Iron may influence severity and progression of non-hemochromatotic liver diseases. Our aim was to assess the relationship of iron and HFE genetic variations to progression and outcomes in the HALT-C Trial and whether PegIFN therapy influenced iron variables.
METHODS : Participants were randomized to receive long-term PegIFN [n = 400] or no therapy [n = 413] for 3.5 y, with follow-up for up to 8.7 y [median 6.0 y]. Associations of patient characteristics with iron variables at baseline and over time were carried out using Kaplan-Meier analyses, Cox regression models, and repeated measures analysis of covariance.
RESULTS : Participants who developed clinical outcomes [CTP > 7, ascites, encephalopathy, variceal bleeding, SBP, HCC, death] had significantly higher baseline scores for stainable iron in hepatocytes and in portal tract cells than those without. There were significant direct correlations between stainable iron in portal triads and lobular and total Ishak inflammatory and fibrosis scores [P < 0.0001]. Iron in triads at baseline increased risk of outcomes (HR = 1.35, P = 0.02). Stainable iron in hepatocytes decreased, whereas that in portal stromal cells increased significantly [P < 0.0001] over time. Serum iron and TIBC fell significantly over time [P < 0.0001], as did serum ferritin [P = 0.0003]. Chronic PegIFN treatment did not affect stainable iron. HFE genetic variations did not correlate with outcomes, including development of hepatocellular carcinoma.
CONCLUSIONS : Stainable iron in hepatocytes and portal tract cells is a predictor of progression and clinical and histological outcomes in advanced chronic hepatitis C. Chronic low-dose PegIFN therapy did not improve outcomes, nor iron variables.
Publication: Gastroenterology 2011 May ;140(5)::1490-500.e3. :doi: 10.1053/j.gastro.2011.01.053.
Publication Date: 2011 May
Study Author(s): Lambrecht, Richard W;Sterling, Richard K;Naishadham, Deepa;Stoddard, Anne M;Rogers, Thomas;Morishima, Chihiro;Morgan, Timothy R;Bonkovsky, Herbert L;HALT-C Trial Group;
Institution: Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA.
Shortcut link to this study:
Publication Date: 2011 May
Study Author(s): Lambrecht, Richard W;Sterling, Richard K;Naishadham, Deepa;Stoddard, Anne M;Rogers, Thomas;Morishima, Chihiro;Morgan, Timothy R;Bonkovsky, Herbert L;HALT-C Trial Group;
Institution: Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA.
Shortcut link to this study:
BACKGROUND & AIMS : Iron may influence severity and progression of non-hemochromatotic liver diseases. Our aim was to assess the relationship of iron and HFE genetic variations to progression and outcomes in the HALT-C Trial and whether PegIFN therapy influenced iron variables.
METHODS : Participants were randomized to receive long-term PegIFN [n = 400] or no therapy [n = 413] for 3.5 y, with follow-up for up to 8.7 y [median 6.0 y]. Associations of patient characteristics with iron variables at baseline and over time were carried out using Kaplan-Meier analyses, Cox regression models, and repeated measures analysis of covariance.
RESULTS : Participants who developed clinical outcomes [CTP > 7, ascites, encephalopathy, variceal bleeding, SBP, HCC, death] had significantly higher baseline scores for stainable iron in hepatocytes and in portal tract cells than those without. There were significant direct correlations between stainable iron in portal triads and lobular and total Ishak inflammatory and fibrosis scores [P < 0.0001]. Iron in triads at baseline increased risk of outcomes (HR = 1.35, P = 0.02). Stainable iron in hepatocytes decreased, whereas that in portal stromal cells increased significantly [P < 0.0001] over time. Serum iron and TIBC fell significantly over time [P < 0.0001], as did serum ferritin [P = 0.0003]. Chronic PegIFN treatment did not affect stainable iron. HFE genetic variations did not correlate with outcomes, including development of hepatocellular carcinoma.
CONCLUSIONS : Stainable iron in hepatocytes and portal tract cells is a predictor of progression and clinical and histological outcomes in advanced chronic hepatitis C. Chronic low-dose PegIFN therapy did not improve outcomes, nor iron variables.
METHODS : Participants were randomized to receive long-term PegIFN [n = 400] or no therapy [n = 413] for 3.5 y, with follow-up for up to 8.7 y [median 6.0 y]. Associations of patient characteristics with iron variables at baseline and over time were carried out using Kaplan-Meier analyses, Cox regression models, and repeated measures analysis of covariance.
RESULTS : Participants who developed clinical outcomes [CTP > 7, ascites, encephalopathy, variceal bleeding, SBP, HCC, death] had significantly higher baseline scores for stainable iron in hepatocytes and in portal tract cells than those without. There were significant direct correlations between stainable iron in portal triads and lobular and total Ishak inflammatory and fibrosis scores [P < 0.0001]. Iron in triads at baseline increased risk of outcomes (HR = 1.35, P = 0.02). Stainable iron in hepatocytes decreased, whereas that in portal stromal cells increased significantly [P < 0.0001] over time. Serum iron and TIBC fell significantly over time [P < 0.0001], as did serum ferritin [P = 0.0003]. Chronic PegIFN treatment did not affect stainable iron. HFE genetic variations did not correlate with outcomes, including development of hepatocellular carcinoma.
CONCLUSIONS : Stainable iron in hepatocytes and portal tract cells is a predictor of progression and clinical and histological outcomes in advanced chronic hepatitis C. Chronic low-dose PegIFN therapy did not improve outcomes, nor iron variables.
PMID: 21335007
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