|
|
char = A;code = 65
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char = O;code = 79
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char = E;code = 69
char = g;code = 103
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char = .;code = 46
result sql = A new hepatoprotective flavone glycoside from the flowers of Onopordum alexandrinum growing in Egypt.
A new hepatoprotective flavone glycoside from the flowers of Onopordum alexandrinum growing in Egypt.char = A;code = 65
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char = o;code = 111
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char = i;code = 105
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char = ;code = 32
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char = r;code = 114
char = e;code = 101
char = e;code = 101
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char = i;code = 105
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char = n;code = 110
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char = f;code = 102
char = e;code = 101
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char = ;code = 32
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char = t;code = 116
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char = t;code = 116
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char = s;code = 115
char = c;code = 99
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char = p;code = 112
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char = ;code = 32
char = m;code = 109
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char = s;code = 115
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char = V;code = 86
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char = H;code = 72
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char = N;code = 78
char = M;code = 77
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char = ,;code = 44
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char = 3;code = 51
char = C;code = 67
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char = N;code = 78
char = M;code = 77
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char = ;code = 32
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char = ;code = 32
char = H;code = 72
char = M;code = 77
char = B;code = 66
char = C;code = 67
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char = d;code = 100
char = ;code = 32
char = C;code = 67
char = O;code = 79
char = S;code = 83
char = Y;code = 89
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char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
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char = >;code = 62
result sql = A bioactivity-guided fractionation of the ethyl acetate fraction of the flowers of Onopordum alexandrinum L. (Asteraceae) yielded a new flavonoidal glycoside designated as acacetin-7-O-galacturonide (9), alongside with nine known flavonoids; 6-methoxy-apigenin (hispidulin) (1), acacetin (2), apigenin (3), luteolin (4), kaempferol (5), eriodictyol (6), apigenin-7-O-glucoside (7), luteolin-7-O-glucoside (8), and kaempferol-3-O-rutinoside (10). The compounds were assayed for their hepatoprotective activity against CCl4-induced hepatic cell damage in rats and free radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH). Compounds 4, 6, 9, and 10 have not been previously reported from flowers of O. alexandrinum L., and this is the first report of acacetin-7-O-galacturonide (9) in nature which has also shown significant hepatoprotective and free radical scavenging effects. The isolated compounds were identified using different spectroscopic methods (UV, 1H NMR, 13C NMR, HMQC, HMBC, and COSY).
char = ;code = 32
char = n;code = 110
char = e;code = 101
char = w;code = 119
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = l;code = 108
char = a;code = 97
char = v;code = 118
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = l;code = 108
char = y;code = 121
char = c;code = 99
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = d;code = 100
char = e;code = 101
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char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = f;code = 102
char = l;code = 108
char = o;code = 111
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char = e;code = 101
char = r;code = 114
char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = o;code = 111
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char = o;code = 111
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char = e;code = 101
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char = d;code = 100
char = r;code = 114
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char = n;code = 110
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = E;code = 69
char = g;code = 103
char = y;code = 121
char = p;code = 112
char = t;code = 116
char = .;code = 46
result sql = A new hepatoprotective flavone glycoside from the flowers of Onopordum alexandrinum growing in Egypt.
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char = b;code = 98
char = i;code = 105
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result sql = A bioactivity-guided fractionation of the ethyl acetate fraction of the flowers of Onopordum alexandrinum L. (Asteraceae) yielded a new flavonoidal glycoside designated as acacetin-7-O-galacturonide (9), alongside with nine known flavonoids; 6-methoxy-apigenin (hispidulin) (1), acacetin (2), apigenin (3), luteolin (4), kaempferol (5), eriodictyol (6), apigenin-7-O-glucoside (7), luteolin-7-O-glucoside (8), and kaempferol-3-O-rutinoside (10). The compounds were assayed for their hepatoprotective activity against CCl4-induced hepatic cell damage in rats and free radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH). Compounds 4, 6, 9, and 10 have not been previously reported from flowers of O. alexandrinum L., and this is the first report of acacetin-7-O-galacturonide (9) in nature which has also shown significant hepatoprotective and free radical scavenging effects. The isolated compounds were identified using different spectroscopic methods (UV, 1H NMR, 13C NMR, HMQC, HMBC, and COSY).
Publication: Z. Naturforsch., C, J. Biosci. 2011 May-Jun ;66(5-6)::251-9.
Publication Date: 2011 May-Jun
Study Author(s): Salama, Maha M;Ezzat, Shahira M;Sleem, Amany A;
Institution: Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr el-Aini street, 11562 Cairo, Egypt. [email protected]
Shortcut link to this study:
Publication Date: 2011 May-Jun
Study Author(s): Salama, Maha M;Ezzat, Shahira M;Sleem, Amany A;
Institution: Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr el-Aini street, 11562 Cairo, Egypt. [email protected]
Shortcut link to this study:
A bioactivity-guided fractionation of the ethyl acetate fraction of the flowers of Onopordum alexandrinum L. (Asteraceae) yielded a new flavonoidal glycoside designated as acacetin-7-O-galacturonide (9), alongside with nine known flavonoids; 6-methoxy-apigenin (hispidulin) (1), acacetin (2), apigenin (3), luteolin (4), kaempferol (5), eriodictyol (6), apigenin-7-O-glucoside (7), luteolin-7-O-glucoside (8), and kaempferol-3-O-rutinoside (10). The compounds were assayed for their hepatoprotective activity against CCl4-induced hepatic cell damage in rats and free radical scavenging activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH). Compounds 4, 6, 9, and 10 have not been previously reported from flowers of O. alexandrinum L., and this is the first report of acacetin-7-O-galacturonide (9) in nature which has also shown significant hepatoprotective and free radical scavenging effects. The isolated compounds were identified using different spectroscopic methods (UV, 1H NMR, 13C NMR, HMQC, HMBC, and COSY).
PMID: 21812342
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