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result sql = Direct assessment by electron spin resonance spectroscopy of the antioxidant effects of French maritime pine bark extract in the maxillofacial region of hairless mice.
Direct assessment by electron spin resonance spectroscopy of the antioxidant effects of French maritime pine bark extract in the maxillofacial region of hairless mice.
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char = l;code = 108
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char = c;code = 99
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char = b;code = 98
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char = i;code = 105
char = c;code = 99
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char = l;code = 108
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char = ;code = 32
char = s;code = 115
char = k;code = 107
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char = n;code = 110
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char = r;code = 114
char = o;code = 111
char = m;code = 109
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char = e;code = 101
char = x;code = 120
char = p;code = 112
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char = r;code = 114
char = e;code = 101
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char = o;code = 111
char = ;code = 32
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char = t;code = 116
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char = o;code = 111
char = l;code = 108
char = e;code = 101
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char = ;code = 32
char = i;code = 105
char = r;code = 114
char = r;code = 114
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char = d;code = 100
char = i;code = 105
char = a;code = 97
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char = i;code = 105
char = o;code = 111
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char = /;code = 47
char = >;code = 62
result sql = Flavangenol, one of extract of French maritime pine bark, is a complex mixture of bioflavonoids with oligometric proanthocyanidins as the major constituents. These constituents, catechin and procyanidin B(1), are water-soluble derivatives of flavangenol. In this study, we investigated the antioxidant effects of flavangenol on reactive oxygen species such as hydroxyl radical, superoxide anion and singlet oxygen using electron spin resonance and spin trapping. The effect of flavangenol on oxidative stress in the skin from the maxillofacial region of hairless mice was investigated using an in vivo L-band electron spin resonance imaging system. Flavangenol attenuated oxidative stress in the maxillofacial skin by acting as a reactive oxygen species scavenger, as demonstrated by in vitro and in vivo electron spin resonance imaging analysis. The absorption and metabolism of flavangenol were also examined. After oral administration of flavangenol in human and rat, most of the catechin in plasma was in the conjugated form, while 45% to 78% of procyanidin B(1) was unconjugated, indicating that non-conjugated procyanidin B(1) would be active in the circulation. The ability of flavangenol to reduce reactive oxygen species levels in the circulation of the maxillofacial region suggests that this extract may be beneficial for skin protection from exposure to ultraviolet irradiation.

Publication: J Clin Biochem Nutr 2011 Sep ;49(2)::79-86. :doi: 10.3164/jcbn.10-103.
Publication Date: 2011 Sep
Study Author(s): Yoshida, Ayaka;Yoshino, Fumihiko;Tsubata, Masahito;Ikeguchi, Motoya;Nakamura, Takeshi;Lee, Masaichi-Chang-Il;
Institution: Department of Clinical Care Medicine, Division of Pharmacology and ESR Laboratories, Kanagawa Dental College, 82 Inaoka-cho, Yokosuka, Kanagawa 238-8580, Japan.
Shortcut link to this study:
Flavangenol, one of extract of French maritime pine bark, is a complex mixture of bioflavonoids with oligometric proanthocyanidins as the major constituents. These constituents, catechin and procyanidin B(1), are water-soluble derivatives of flavangenol. In this study, we investigated the antioxidant effects of flavangenol on reactive oxygen species such as hydroxyl radical, superoxide anion and singlet oxygen using electron spin resonance and spin trapping. The effect of flavangenol on oxidative stress in the skin from the maxillofacial region of hairless mice was investigated using an in vivo L-band electron spin resonance imaging system. Flavangenol attenuated oxidative stress in the maxillofacial skin by acting as a reactive oxygen species scavenger, as demonstrated by in vitro and in vivo electron spin resonance imaging analysis. The absorption and metabolism of flavangenol were also examined. After oral administration of flavangenol in human and rat, most of the catechin in plasma was in the conjugated form, while 45% to 78% of procyanidin B(1) was unconjugated, indicating that non-conjugated procyanidin B(1) would be active in the circulation. The ability of flavangenol to reduce reactive oxygen species levels in the circulation of the maxillofacial region suggests that this extract may be beneficial for skin protection from exposure to ultraviolet irradiation.
PMID: 21980222

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