|
|
char = R;code = 82
char = e;code = 101
char = s;code = 115
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = i;code = 105
char = b;code = 98
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char = t;code = 116
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = r;code = 114
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char = i;code = 105
char = n;code = 110
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char = 4;code = 52
char = 6;code = 54
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char = -;code = 45
char = m;code = 109
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char = d;code = 100
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
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char = b;code = 98
char = l;code = 108
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char = d;code = 100
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char = ;code = 32
char = s;code = 115
char = y;code = 121
char = n;code = 110
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = c;code = 99
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char = o;code = 111
char = n;code = 110
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = c;code = 99
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char = i;code = 105
char = v;code = 118
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = S;code = 83
char = I;code = 73
char = R;code = 82
char = T;code = 84
char = 1;code = 49
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
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char = h;code = 104
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = n;code = 110
char = u;code = 117
char = c;code = 99
char = l;code = 108
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = -;code = 45
char = &;code = 38
char = #;code = 35
char = 9;code = 57
char = 5;code = 53
char = 4;code = 52
char = ;;code = 59
char = B;code = 66
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = .;code = 46
result sql = Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity.
Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity.char = I;code = 73
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char = ;code = 32
char = c;code = 99
char = h;code = 104
char = o;code = 111
char = n;code = 110
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = n;code = 110
char = a;code = 97
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = S;code = 83
char = I;code = 73
char = R;code = 82
char = T;code = 84
char = 1;code = 49
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ,;code = 44
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = e;code = 101
char = r;code = 114
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = t;code = 116
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char = i;code = 105
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char = l;code = 108
char = a;code = 97
char = m;code = 109
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = o;code = 111
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char = y;code = 121
char = ;code = 32
char = r;code = 114
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char = s;code = 115
char = p;code = 112
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char = ;code = 32
char = v;code = 118
char = i;code = 105
char = a;code = 97
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = n;code = 110
char = u;code = 117
char = c;code = 99
char = l;code = 108
char = e;code = 101
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
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char = ;code = 32
char = k;code = 107
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = a;code = 97
char = B;code = 66
char = ;code = 32
char = (;code = 40
char = N;code = 78
char = F;code = 70
char = -;code = 45
char = &;code = 38
char = #;code = 35
char = 9;code = 57
char = 5;code = 53
char = 4;code = 52
char = ;;code = 59
char = B;code = 66
char = );code = 41
char = .;code = 46
char = ;code = 32
char = G;code = 71
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = S;code = 83
char = I;code = 73
char = R;code = 82
char = T;code = 84
char = 1;code = 49
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char = i;code = 105
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char = i;code = 105
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char = a;code = 97
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char = i;code = 105
char = a;code = 97
char = l;code = 108
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char = o;code = 111
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char = N;code = 78
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char = N;code = 78
char = F;code = 70
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char = ,;code = 44
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char = e;code = 101
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char = f;code = 102
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = r;code = 114
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char = v;code = 118
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = -;code = 45
char = a;code = 97
char = c;code = 99
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char = i;code = 105
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char = a;code = 97
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char = e;code = 101
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char = R;code = 82
char = T;code = 84
char = 1;code = 49
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char = .;code = 46
char = ;code = 32
char = W;code = 87
char = e;code = 101
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char = f;code = 102
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char = h;code = 104
char = a;code = 97
char = t;code = 116
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char = w;code = 119
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char = e;code = 101
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char = c;code = 99
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char = o;code = 111
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char = o;code = 111
char = c;code = 99
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char = e;code = 101
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = m;code = 109
char = u;code = 117
char = l;code = 108
char = a;code = 97
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char = e;code = 101
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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char = (;code = 40
char = I;code = 73
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char = &;code = 38
char = #;code = 35
char = 9;code = 57
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char = 6;code = 54
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char = );code = 41
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char = t;code = 116
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char = l;code = 108
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char = o;code = 111
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char = o;code = 111
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char = ;code = 32
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char = c;code = 99
char = e;code = 101
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char = h;code = 104
char = i;code = 105
char = c;code = 99
char = h;code = 104
char = ;code = 32
char = m;code = 109
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char = s;code = 115
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char = b;code = 98
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
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char = t;code = 116
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char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = s;code = 115
char = a;code = 97
char = c;code = 99
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char = i;code = 105
char = v;code = 118
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
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char = v;code = 118
char = i;code = 105
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char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = m;code = 109
char = m;code = 109
char = e;code = 101
char = d;code = 100
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = d;code = 100
char = o;code = 111
char = w;code = 119
char = n;code = 110
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = m;code = 109
char = ;code = 32
char = t;code = 116
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = S;code = 83
char = I;code = 73
char = R;code = 82
char = T;code = 84
char = 1;code = 49
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = S;code = 83
char = I;code = 73
char = R;code = 82
char = T;code = 84
char = 1;code = 49
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = f;code = 102
char = l;code = 108
char = a;code = 97
char = m;code = 109
char = m;code = 109
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = p;code = 112
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
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char = b;code = 98
char = y;code = 121
char = ;code = 32
char = I;code = 73
char = L;code = 76
char = -;code = 45
char = 1;code = 49
char = &;code = 38
char = #;code = 35
char = 9;code = 57
char = 4;code = 52
char = 6;code = 54
char = ;;code = 59
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = o;code = 111
char = n;code = 110
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = e;code = 101
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char = .;code = 46
char = ;code = 32
char = R;code = 82
char = e;code = 101
char = s;code = 115
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = r;code = 114
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char = l;code = 108
char = ,;code = 44
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char = a;code = 97
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char = a;code = 97
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = c;code = 99
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char = t;code = 116
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char = r;code = 114
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = S;code = 83
char = I;code = 73
char = R;code = 82
char = T;code = 84
char = 1;code = 49
char = ,;code = 44
char = ;code = 32
char = m;code = 109
char = e;code = 101
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char = o;code = 111
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char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = e;code = 101
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char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = g;code = 103
char = e;code = 101
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char = t;code = 116
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = m;code = 109
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = p;code = 112
char = r;code = 114
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char = v;code = 118
char = e;code = 101
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char = o;code = 111
char = n;code = 110
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char = o;code = 111
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char = ;code = 32
char = o;code = 111
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char = t;code = 116
char = e;code = 101
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result sql = In chondrocytes, resveratrol, a natural SIRT1 activator, exerts an anti-inflammatory response via inhibition of nuclear factor kappaB (NF-κB). Given that SIRT1 inhibits the transactivation potential of NF-κB by deacetylating acetylated lysines in p65, the NF-κB subunit, we investigated the effects of resveratrol-activated SIRT1 on articular chondrocytes. We found that when chondrocytes were stimulated with interleukin 1β (IL-1β), the time- and dose-dependent expression of inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production was suppressed by resveratrol. Resveratrol-activated SIRT1 mediated this suppression. SIRT1 suppressed not only the nuclear translocation of NF-κB but also the acetylation of p65. Furthermore, acetylated Lys310 in p65, which must be present for transactivation activity, was the immediate downstream target of SIRT1. Therefore, SIRT1 protects against the inflammatory response induced by IL-1β in articular chondrocytes. Resveratrol, as an activator of SIRT1, merits consideration as a therapeutic agent in the treatment and prevention of osteoarthritis.
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char = o;code = 111
char = l;code = 108
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char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
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char = s;code = 115
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char = i;code = 105
char = n;code = 110
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char = l;code = 108
char = e;code = 101
char = u;code = 117
char = k;code = 107
char = i;code = 105
char = n;code = 110
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char = 1;code = 49
char = &;code = 38
char = #;code = 35
char = 9;code = 57
char = 4;code = 52
char = 6;code = 54
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char = -;code = 45
char = m;code = 109
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char = d;code = 100
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char = c;code = 99
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char = t;code = 116
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = c;code = 99
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char = i;code = 105
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char = a;code = 97
char = t;code = 116
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char = n;code = 110
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char = S;code = 83
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char = R;code = 82
char = T;code = 84
char = 1;code = 49
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
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char = e;code = 101
char = b;code = 98
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char = u;code = 117
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char = p;code = 112
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char = s;code = 115
char = s;code = 115
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char = g;code = 103
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char = n;code = 110
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char = c;code = 99
char = l;code = 108
char = e;code = 101
char = a;code = 97
char = r;code = 114
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char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
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char = &;code = 38
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char = 5;code = 53
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char = a;code = 97
char = c;code = 99
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char = v;code = 118
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = .;code = 46
result sql = Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity.
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char = ;code = 32
char = o;code = 111
char = f;code = 102
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char = l;code = 108
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char = h;code = 104
char = a;code = 97
char = t;code = 116
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char = S;code = 83
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char = T;code = 84
char = 1;code = 49
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char = e;code = 101
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char = r;code = 114
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char = s;code = 115
char = a;code = 97
char = c;code = 99
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char = o;code = 111
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char = ;code = 32
char = N;code = 78
char = F;code = 70
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char = &;code = 38
char = #;code = 35
char = 9;code = 57
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char = ;code = 32
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char = ;code = 32
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char = m;code = 109
char = o;code = 111
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char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = c;code = 99
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char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = L;code = 76
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char = c;code = 99
char = h;code = 104
char = ;code = 32
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char = o;code = 111
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char = a;code = 97
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char = a;code = 97
char = c;code = 99
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char = v;code = 118
char = a;code = 97
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char = o;code = 111
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char = ;code = 32
char = a;code = 97
char = c;code = 99
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char = i;code = 105
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char = i;code = 105
char = t;code = 116
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char = ;code = 32
char = w;code = 119
char = a;code = 97
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char = ;code = 32
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char = i;code = 105
char = m;code = 109
char = m;code = 109
char = e;code = 101
char = d;code = 100
char = i;code = 105
char = a;code = 97
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char = e;code = 101
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char = o;code = 111
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char = n;code = 110
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char = a;code = 97
char = m;code = 109
char = ;code = 32
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char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = S;code = 83
char = I;code = 73
char = R;code = 82
char = T;code = 84
char = 1;code = 49
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = S;code = 83
char = I;code = 73
char = R;code = 82
char = T;code = 84
char = 1;code = 49
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
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char = t;code = 116
char = s;code = 115
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char = a;code = 97
char = g;code = 103
char = a;code = 97
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char = n;code = 110
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char = t;code = 116
char = h;code = 104
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char = a;code = 97
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char = m;code = 109
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char = r;code = 114
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char = s;code = 115
char = p;code = 112
char = o;code = 111
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char = s;code = 115
char = e;code = 101
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char = i;code = 105
char = n;code = 110
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char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = I;code = 73
char = L;code = 76
char = -;code = 45
char = 1;code = 49
char = &;code = 38
char = #;code = 35
char = 9;code = 57
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char = ;code = 32
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char = n;code = 110
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char = a;code = 97
char = r;code = 114
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char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = c;code = 99
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char = o;code = 111
char = n;code = 110
char = d;code = 100
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char = o;code = 111
char = c;code = 99
char = y;code = 121
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char = e;code = 101
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char = .;code = 46
char = ;code = 32
char = R;code = 82
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char = s;code = 115
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = a;code = 97
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char = a;code = 97
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char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = S;code = 83
char = I;code = 73
char = R;code = 82
char = T;code = 84
char = 1;code = 49
char = ,;code = 44
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = r;code = 114
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char = t;code = 116
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char = a;code = 97
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char = ;code = 32
char = a;code = 97
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char = t;code = 116
char = h;code = 104
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char = r;code = 114
char = a;code = 97
char = p;code = 112
char = e;code = 101
char = u;code = 117
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = t;code = 116
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = m;code = 109
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char = n;code = 110
char = t;code = 116
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = p;code = 112
char = r;code = 114
char = e;code = 101
char = v;code = 118
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char = n;code = 110
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = o;code = 111
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char = t;code = 116
char = e;code = 101
char = o;code = 111
char = a;code = 97
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char = h;code = 104
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char = t;code = 116
char = i;code = 105
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char = /;code = 47
char = >;code = 62
result sql = In chondrocytes, resveratrol, a natural SIRT1 activator, exerts an anti-inflammatory response via inhibition of nuclear factor kappaB (NF-κB). Given that SIRT1 inhibits the transactivation potential of NF-κB by deacetylating acetylated lysines in p65, the NF-κB subunit, we investigated the effects of resveratrol-activated SIRT1 on articular chondrocytes. We found that when chondrocytes were stimulated with interleukin 1β (IL-1β), the time- and dose-dependent expression of inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production was suppressed by resveratrol. Resveratrol-activated SIRT1 mediated this suppression. SIRT1 suppressed not only the nuclear translocation of NF-κB but also the acetylation of p65. Furthermore, acetylated Lys310 in p65, which must be present for transactivation activity, was the immediate downstream target of SIRT1. Therefore, SIRT1 protects against the inflammatory response induced by IL-1β in articular chondrocytes. Resveratrol, as an activator of SIRT1, merits consideration as a therapeutic agent in the treatment and prevention of osteoarthritis.
Publication: Eur. J. Pharmacol. 2012 Jan 15 ;674(2-3)::73-9. :doi: 10.1016/j.ejphar.2011.10.015.
Publication Date: 2012 Jan 15
Study Author(s): Lei, Ming;Wang, Ji-guo;Xiao, De-ming;Fan, Meng;Wang, Da-ping;Xiong, Jian-yi;Chen, Yang;Ding, Yue;Liu, Shang-li;
Institution: Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No.107, Yanjiang West Road, 510120, Guangzhou, Guangdong Province, People's Republic of China.
Shortcut link to this study:
Publication Date: 2012 Jan 15
Study Author(s): Lei, Ming;Wang, Ji-guo;Xiao, De-ming;Fan, Meng;Wang, Da-ping;Xiong, Jian-yi;Chen, Yang;Ding, Yue;Liu, Shang-li;
Institution: Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No.107, Yanjiang West Road, 510120, Guangzhou, Guangdong Province, People's Republic of China.
Shortcut link to this study:
In chondrocytes, resveratrol, a natural SIRT1 activator, exerts an anti-inflammatory response via inhibition of nuclear factor kappaB (NF-κB). Given that SIRT1 inhibits the transactivation potential of NF-κB by deacetylating acetylated lysines in p65, the NF-κB subunit, we investigated the effects of resveratrol-activated SIRT1 on articular chondrocytes. We found that when chondrocytes were stimulated with interleukin 1β (IL-1β), the time- and dose-dependent expression of inducible nitric oxide synthase (iNOS) expression and nitric oxide (NO) production was suppressed by resveratrol. Resveratrol-activated SIRT1 mediated this suppression. SIRT1 suppressed not only the nuclear translocation of NF-κB but also the acetylation of p65. Furthermore, acetylated Lys310 in p65, which must be present for transactivation activity, was the immediate downstream target of SIRT1. Therefore, SIRT1 protects against the inflammatory response induced by IL-1β in articular chondrocytes. Resveratrol, as an activator of SIRT1, merits consideration as a therapeutic agent in the treatment and prevention of osteoarthritis.
PMID: 22044919
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