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char = e;code = 101
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char = o;code = 111
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char = m;code = 109
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char = b;code = 98
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char = o;code = 111
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char = i;code = 105
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char = t;code = 116
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char = .;code = 46
result sql = Effect of garlic sulfur compounds on neutrophil infiltration and damage to the intestinal mucosa by endotoxin in rats.
Effect of garlic sulfur compounds on neutrophil infiltration and damage to the intestinal mucosa by endotoxin in rats.
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char = f;code = 102
char = e;code = 101
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char = d;code = 100
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char = a;code = 97
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char = l;code = 108
char = y;code = 121
char = l;code = 108
char = ;code = 32
char = t;code = 116
char = r;code = 114
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char = s;code = 115
char = u;code = 117
char = l;code = 108
char = f;code = 102
char = i;code = 105
char = d;code = 100
char = e;code = 101
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char = (;code = 40
char = D;code = 68
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char = T;code = 84
char = S;code = 83
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char = e;code = 101
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char = d;code = 100
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char = o;code = 111
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char = m;code = 109
char = a;code = 97
char = g;code = 103
char = e;code = 101
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char = W;code = 87
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char = g;code = 103
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char = e;code = 101
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char = ;code = 32
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char = G;code = 71
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char = y;code = 121
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char = e;code = 101
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char = e;code = 101
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char = e;code = 101
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char = b;code = 98
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char = h;code = 104
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char = );code = 41
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char = C;code = 67
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char = l;code = 108
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char = C;code = 67
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char = p;code = 112
char = h;code = 104
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char = o;code = 111
char = g;code = 103
char = y;code = 121
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char = ;code = 32
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char = A;code = 65
char = S;code = 83
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char = D;code = 68
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result sql = We investigated the protective effects of garlic sulfur compounds (GSCs), specifically, diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS), on endotoxin-induced intestinal damage. Wistar rats received by gavage 0.125 or 0.025 mmol/kg body wt of each GSC or the vehicle (corn oil; 2 mL/kg body wt) every other day for 2 weeks before being injected with endotoxin (ip, 5 mg/kg body wt). Control rats were administered corn oil and were injected with sterile saline. Rats were killed at 18 h after injection. Both doses of DAS suppressed endotoxin-induced neutrophilia, serum levels of sICAM-1 and CINC-1, cellular CD11b on neutrophils, and intestinal contents of ICAM-1, CINC-1, TNF-alpha, and IL-1beta (p<0.05) DADS : suppressed endotoxin-induced intestinal contents of ICAM-1, TNF-alpha, and IL-1beta at both doses, but only suppressed the serum sICAM-1 level and cellular CD11b on neutrophils at the low dose (p<0.05).

DATS : did not ameliorate the endotoxin-induced serum level of sICAM-1 or CINC-1 but suppressed intestinal IL-1beta at both doses. The low but not the high dose of DATS also ameliorated the intestinal contents of ICAM-1 and TNF-alpha (p<0.05). All GSCs reversed endotoxin-induced neutrophil infiltration and damage in the intestine, and the order of the effects of these GSCs to normalize intestinal morphology was DAS>DADS>DATS.

Publication: Food Chem. Toxicol. 2012 Mar ;50(3-4)::567-74. :doi: 10.1016/j.fct.2011.11.027.
Publication Date: 2012 Mar
Study Author(s): Lee, Shih-Hua;Liu, Yu-Ting;Chen, Ke-Ming;Lii, Chong-Kuei;Liu, Cheng-Tzu;
Institution: School of Nutrition, Department of Parasitology, Chung Shan Medical University, and Department of Nutrition, Chung Shan Medical University Hospital, Taichung 402, Taiwan.
Shortcut link to this study:
We investigated the protective effects of garlic sulfur compounds (GSCs), specifically, diallyl sulfide (DAS), diallyl disulfide (DADS), and diallyl trisulfide (DATS), on endotoxin-induced intestinal damage. Wistar rats received by gavage 0.125 or 0.025 mmol/kg body wt of each GSC or the vehicle (corn oil; 2 mL/kg body wt) every other day for 2 weeks before being injected with endotoxin (ip, 5 mg/kg body wt). Control rats were administered corn oil and were injected with sterile saline. Rats were killed at 18 h after injection. Both doses of DAS suppressed endotoxin-induced neutrophilia, serum levels of sICAM-1 and CINC-1, cellular CD11b on neutrophils, and intestinal contents of ICAM-1, CINC-1, TNF-alpha, and IL-1beta (p<0.05) DADS : suppressed endotoxin-induced intestinal contents of ICAM-1, TNF-alpha, and IL-1beta at both doses, but only suppressed the serum sICAM-1 level and cellular CD11b on neutrophils at the low dose (p<0.05).

DATS : did not ameliorate the endotoxin-induced serum level of sICAM-1 or CINC-1 but suppressed intestinal IL-1beta at both doses. The low but not the high dose of DATS also ameliorated the intestinal contents of ICAM-1 and TNF-alpha (p<0.05). All GSCs reversed endotoxin-induced neutrophil infiltration and damage in the intestine, and the order of the effects of these GSCs to normalize intestinal morphology was DAS>DADS>DATS.
PMID: 22138247

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