|
|
char = E;code = 69
char = r;code = 114
char = i;code = 105
char = o;code = 111
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char = i;code = 105
char = c;code = 99
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char = y;code = 121
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char = O;code = 79
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char = ;code = 32
char = N;code = 78
char = r;code = 114
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char = 2;code = 50
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char = a;code = 97
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char = ,;code = 44
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char = p;code = 112
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char = t;code = 116
char = ;code = 32
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char = s;code = 115
char = p;code = 112
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char = i;code = 105
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char = e;code = 101
char = d;code = 100
char = ;code = 32
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char = o;code = 111
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char = c;code = 99
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char = t;code = 116
char = y;code = 121
char = .;code = 46
result sql = Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity.
Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity.char = E;code = 69
char = r;code = 114
char = i;code = 105
char = o;code = 111
char = d;code = 100
char = i;code = 105
char = c;code = 99
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char = y;code = 121
char = o;code = 111
char = l;code = 108
char = -;code = 45
char = 7;code = 55
char = -;code = 45
char = O;code = 79
char = -;code = 45
char = g;code = 103
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char = u;code = 117
char = c;code = 99
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char = s;code = 115
char = i;code = 105
char = d;code = 100
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char = ,;code = 44
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char = a;code = 97
char = ;code = 32
char = f;code = 102
char = l;code = 108
char = a;code = 97
char = v;code = 118
char = o;code = 111
char = n;code = 110
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char = d;code = 100
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char = e;code = 101
char = d;code = 100
char = ;code = 32
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char = o;code = 111
char = m;code = 109
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char = D;code = 68
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = o;code = 111
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char = e;code = 101
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char = h;code = 104
char = a;code = 97
char = l;code = 108
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char = m;code = 109
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char = e;code = 101
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char = e;code = 101
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char = t;code = 116
char = ;code = 32
char = f;code = 102
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char = e;code = 101
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = a;code = 97
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char = a;code = 97
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char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = y;code = 121
char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = e;code = 101
char = r;code = 114
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char = i;code = 105
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char = -;code = 45
char = O;code = 79
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char = g;code = 103
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char = c;code = 99
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char = s;code = 115
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char = d;code = 100
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char = a;code = 97
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char = ;code = 32
char = a;code = 97
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char = n;code = 110
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char = e;code = 101
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char = n;code = 110
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char = c;code = 99
char = l;code = 108
char = e;code = 101
char = a;code = 97
char = r;code = 114
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char = a;code = 97
char = c;code = 99
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char = E;code = 69
char = 2;code = 50
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char = e;code = 101
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char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
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char = ;code = 32
char = 2;code = 50
char = ;code = 32
char = (;code = 40
char = N;code = 78
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char = a;code = 97
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char = g;code = 103
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char = u;code = 117
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char = c;code = 99
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char = l;code = 108
char = u;code = 117
char = l;code = 108
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char = s;code = 115
char = c;code = 99
char = r;code = 114
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char = e;code = 101
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char = p;code = 112
char = o;code = 111
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char = ;code = 32
char = a;code = 97
char = c;code = 99
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char = i;code = 105
char = v;code = 118
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = N;code = 78
char = r;code = 114
char = f;code = 102
char = 2;code = 50
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char = g;code = 103
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char = a;code = 97
char = b;code = 98
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char = s;code = 115
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char = a;code = 97
char = b;code = 98
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char = l;code = 108
char = i;code = 105
char = z;code = 122
char = e;code = 101
char = ;code = 32
char = N;code = 78
char = r;code = 114
char = f;code = 102
char = 2;code = 50
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char = b;code = 98
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char = d;code = 100
char = e;code = 101
char = l;code = 108
char = a;code = 97
char = y;code = 121
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char = n;code = 110
char = g;code = 103
char = ;code = 32
char = N;code = 78
char = r;code = 114
char = f;code = 102
char = 2;code = 50
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = g;code = 103
char = r;code = 114
char = a;code = 97
char = d;code = 100
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = i;code = 105
char = n;code = 110
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char = n;code = 110
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char = a;code = 97
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char = 7;code = 55
char = -;code = 45
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char = -;code = 45
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char = l;code = 108
char = u;code = 117
char = c;code = 99
char = o;code = 111
char = s;code = 115
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char = d;code = 100
char = e;code = 101
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char = s;code = 115
char = i;code = 105
char = g;code = 103
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = l;code = 108
char = y;code = 121
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char = i;code = 105
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char = l;code = 108
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char = s;code = 115
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char = r;code = 114
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char = i;code = 105
char = v;code = 118
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = u;code = 117
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = c;code = 99
char = i;code = 105
char = s;code = 115
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = n;code = 110
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char = e;code = 101
char = x;code = 120
char = p;code = 112
char = o;code = 111
char = s;code = 115
char = u;code = 117
char = r;code = 114
char = e;code = 101
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char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = f;code = 102
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char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = ;code = 32
char = d;code = 100
char = e;code = 101
char = m;code = 109
char = o;code = 111
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char = s;code = 115
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char = r;code = 114
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = o;code = 111
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char = n;code = 110
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char = t;code = 116
char = u;code = 117
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char = c;code = 99
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char = m;code = 109
char = p;code = 112
char = o;code = 111
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char = s;code = 115
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char = t;code = 116
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char = e;code = 101
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char = u;code = 117
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char = a;code = 97
char = p;code = 112
char = p;code = 112
char = r;code = 114
char = o;code = 111
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char = c;code = 99
char = h;code = 104
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = i;code = 105
char = s;code = 115
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = Eriodictyol-7-O-glucoside, a flavonoid isolated from Dracocephalum rupestre, is among the most potent free radical scavenger. In the present study, we identified eriodictyol-7-O-glucoside as a novel nuclear factor E2-related factor 2 (Nrf2) activator using a high-throughput cellular screening method. This compound activated Nrf2 signaling pathway and was able to stabilize Nrf2 by delaying Nrf2 degradation, resulting in accumulation of Nrf2 protein and activation of the Nrf2-dependent protective response. Recent studies have suggested that activation of Nrf2 pathway would confer protection against cisplatin-induced toxicity. The protective role of eriodictyol-7-O-glucoside in cisplatin-induced toxicity was investigated in a human renal mesangial cell line, HRMC. Cotreatment of HRMC cells with eriodictyol-7-O-glucoside significantly improved cell survival under cisplatin exposure. These findings demonstrated the feasibility of using natural compounds targeting Nrf2 as a therapeutic approach to subvert the side effects of cisplatin in normal cells.
char = r;code = 114
char = i;code = 105
char = o;code = 111
char = d;code = 100
char = i;code = 105
char = c;code = 99
char = t;code = 116
char = y;code = 121
char = o;code = 111
char = l;code = 108
char = -;code = 45
char = 7;code = 55
char = -;code = 45
char = O;code = 79
char = -;code = 45
char = g;code = 103
char = l;code = 108
char = u;code = 117
char = c;code = 99
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = n;code = 110
char = o;code = 111
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = ;code = 32
char = N;code = 78
char = r;code = 114
char = f;code = 102
char = 2;code = 50
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ,;code = 44
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = c;code = 99
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char = i;code = 105
char = o;code = 111
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char = a;code = 97
char = g;code = 103
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = i;code = 105
char = s;code = 115
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = -;code = 45
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
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char = t;code = 116
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = .;code = 46
result sql = Eriodictyol-7-O-glucoside, a novel Nrf2 activator, confers protection against cisplatin-induced toxicity.
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char = i;code = 105
char = o;code = 111
char = d;code = 100
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char = y;code = 121
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result sql = Eriodictyol-7-O-glucoside, a flavonoid isolated from Dracocephalum rupestre, is among the most potent free radical scavenger. In the present study, we identified eriodictyol-7-O-glucoside as a novel nuclear factor E2-related factor 2 (Nrf2) activator using a high-throughput cellular screening method. This compound activated Nrf2 signaling pathway and was able to stabilize Nrf2 by delaying Nrf2 degradation, resulting in accumulation of Nrf2 protein and activation of the Nrf2-dependent protective response. Recent studies have suggested that activation of Nrf2 pathway would confer protection against cisplatin-induced toxicity. The protective role of eriodictyol-7-O-glucoside in cisplatin-induced toxicity was investigated in a human renal mesangial cell line, HRMC. Cotreatment of HRMC cells with eriodictyol-7-O-glucoside significantly improved cell survival under cisplatin exposure. These findings demonstrated the feasibility of using natural compounds targeting Nrf2 as a therapeutic approach to subvert the side effects of cisplatin in normal cells.
Publication: Food Chem. Toxicol. 2012 Jun ;50(6)::1927-32. :doi: 10.1016/j.fct.2012.03.059.
Publication Date: 2012 Jun
Study Author(s): Hu, Qingwen;Zhang, Donna D;Wang, Limei;Lou, Hongxiang;Ren, Dongmei;
Institution: Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, Jinan 250012, People's Republic of China.
Shortcut link to this study:
Publication Date: 2012 Jun
Study Author(s): Hu, Qingwen;Zhang, Donna D;Wang, Limei;Lou, Hongxiang;Ren, Dongmei;
Institution: Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, Jinan 250012, People's Republic of China.
Shortcut link to this study:
Eriodictyol-7-O-glucoside, a flavonoid isolated from Dracocephalum rupestre, is among the most potent free radical scavenger. In the present study, we identified eriodictyol-7-O-glucoside as a novel nuclear factor E2-related factor 2 (Nrf2) activator using a high-throughput cellular screening method. This compound activated Nrf2 signaling pathway and was able to stabilize Nrf2 by delaying Nrf2 degradation, resulting in accumulation of Nrf2 protein and activation of the Nrf2-dependent protective response. Recent studies have suggested that activation of Nrf2 pathway would confer protection against cisplatin-induced toxicity. The protective role of eriodictyol-7-O-glucoside in cisplatin-induced toxicity was investigated in a human renal mesangial cell line, HRMC. Cotreatment of HRMC cells with eriodictyol-7-O-glucoside significantly improved cell survival under cisplatin exposure. These findings demonstrated the feasibility of using natural compounds targeting Nrf2 as a therapeutic approach to subvert the side effects of cisplatin in normal cells.
PMID: 22465804
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