|
|
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result sql = Photo-activated riboflavin therapy of refractory corneal ulcers.
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result sql = PURPOSE : To evaluate the therapeutic effect of photo-activated riboflavin (PAR) for treating refractory corneal ulcers.
METHODS : Seven eyes with infectious keratitis, presented with a gradually deteriorating, vision-threatening, corneal ulcer, despite intense antimicrobial therapy, were treated with PAR. The surgical procedure was deepithelialization of the affected corneas followed by UV-A riboflavin (B2) cross-linking. Local antimicrobial therapy was continued after the procedure.
RESULTS : In all cases, the progression of corneal melting was halted after PAR treatment. Emergency keratoplasty was not necessary in any of the 7 eyes presented. More importantly, all the ulcers were healed without significant vascularization.
CONCLUSION : PAR is a promising option for treating patients with therapy-refractory infectious keratitis to avoid emergency keratoplasty and should be considered as a potential adjuvant therapeutic tool in such eyes.
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result sql = Photo-activated riboflavin therapy of refractory corneal ulcers.
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result sql = PURPOSE : To evaluate the therapeutic effect of photo-activated riboflavin (PAR) for treating refractory corneal ulcers.
METHODS : Seven eyes with infectious keratitis, presented with a gradually deteriorating, vision-threatening, corneal ulcer, despite intense antimicrobial therapy, were treated with PAR. The surgical procedure was deepithelialization of the affected corneas followed by UV-A riboflavin (B2) cross-linking. Local antimicrobial therapy was continued after the procedure.
RESULTS : In all cases, the progression of corneal melting was halted after PAR treatment. Emergency keratoplasty was not necessary in any of the 7 eyes presented. More importantly, all the ulcers were healed without significant vascularization.
CONCLUSION : PAR is a promising option for treating patients with therapy-refractory infectious keratitis to avoid emergency keratoplasty and should be considered as a potential adjuvant therapeutic tool in such eyes.
Publication: Cornea 2012 Oct ;31(10)::1210-3. :doi: 10.1097/ICO.0b013e31823f8f48.
Publication Date: 2012 Oct
Study Author(s): Panda, Anita;Krishna, Sasikala N;Kumar, Sandeep;
Institution: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. [email protected]
Shortcut link to this study:
Publication Date: 2012 Oct
Study Author(s): Panda, Anita;Krishna, Sasikala N;Kumar, Sandeep;
Institution: Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. [email protected]
Shortcut link to this study:
PURPOSE : To evaluate the therapeutic effect of photo-activated riboflavin (PAR) for treating refractory corneal ulcers.
METHODS : Seven eyes with infectious keratitis, presented with a gradually deteriorating, vision-threatening, corneal ulcer, despite intense antimicrobial therapy, were treated with PAR. The surgical procedure was deepithelialization of the affected corneas followed by UV-A riboflavin (B2) cross-linking. Local antimicrobial therapy was continued after the procedure.
RESULTS : In all cases, the progression of corneal melting was halted after PAR treatment. Emergency keratoplasty was not necessary in any of the 7 eyes presented. More importantly, all the ulcers were healed without significant vascularization.
CONCLUSION : PAR is a promising option for treating patients with therapy-refractory infectious keratitis to avoid emergency keratoplasty and should be considered as a potential adjuvant therapeutic tool in such eyes.
METHODS : Seven eyes with infectious keratitis, presented with a gradually deteriorating, vision-threatening, corneal ulcer, despite intense antimicrobial therapy, were treated with PAR. The surgical procedure was deepithelialization of the affected corneas followed by UV-A riboflavin (B2) cross-linking. Local antimicrobial therapy was continued after the procedure.
RESULTS : In all cases, the progression of corneal melting was halted after PAR treatment. Emergency keratoplasty was not necessary in any of the 7 eyes presented. More importantly, all the ulcers were healed without significant vascularization.
CONCLUSION : PAR is a promising option for treating patients with therapy-refractory infectious keratitis to avoid emergency keratoplasty and should be considered as a potential adjuvant therapeutic tool in such eyes.
PMID: 22710492
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