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char = e;code = 101
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char = m;code = 109
char = m;code = 109
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char = o;code = 111
char = p;code = 112
char = h;code = 104
char = e;code = 101
char = n;code = 110
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char = t;code = 116
char = y;code = 121
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char = i;code = 105
char = c;code = 99
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char = f;code = 102
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = u;code = 117
char = r;code = 114
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char = s;code = 115
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = a;code = 97
char = t;code = 116
char = e;code = 101
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char = ;code = 32
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char = d;code = 100
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char = v;code = 118
char = e;code = 101
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char = m;code = 109
char = m;code = 109
char = u;code = 117
char = n;code = 110
char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = p;code = 112
char = u;code = 117
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
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char = s;code = 115
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char = g;code = 103
char = n;code = 110
char = a;code = 97
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char = u;code = 117
char = r;code = 114
char = e;code = 101
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = l;code = 108
char = a;code = 97
char = b;code = 98
char = o;code = 111
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = u;code = 117
char = s;code = 115
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char = f;code = 102
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = l;code = 108
char = o;code = 111
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = i;code = 105
char = z;code = 122
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = u;code = 117
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = e;code = 101
char = o;code = 111
char = u;code = 117
char = s;code = 115
char = ;code = 32
char = l;code = 108
char = e;code = 101
char = i;code = 105
char = s;code = 115
char = h;code = 104
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = a;code = 97
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = .;code = 46
result sql = Distinct pattern of immunophenotypic features of innate and adaptive immunity as a putative signature of clinical and laboratorial status of patients with localized cutaneous leishmaniasis.
Distinct pattern of immunophenotypic features of innate and adaptive immunity as a putative signature of clinical and laboratorial status of patients with localized cutaneous leishmaniasis.
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char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = y;code = 121
char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = y;code = 121
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char = d;code = 100
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char = h;code = 104
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char = u;code = 117
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char = o;code = 111
char = f;code = 102
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char = ;code = 32
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char = c;code = 99
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char = L;code = 76
char = C;code = 67
char = L;code = 76
char = );code = 41
char = ,;code = 44
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = g;code = 103
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char = e;code = 101
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char = c;code = 99
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char = g;code = 103
char = ;code = 32
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char = o;code = 111
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char = c;code = 99
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char = a;code = 97
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char = a;code = 97
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char = a;code = 97
char = t;code = 116
char = u;code = 117
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char = ;code = 32
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char = g;code = 103
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char = b;code = 98
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char = ;code = 32
char = l;code = 108
char = e;code = 101
char = s;code = 115
char = i;code = 105
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char = ;code = 32
char = (;code = 40
char = L;code = 76
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char = 8;code = 56
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char = );code = 41
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char = i;code = 105
char = v;code = 118
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char = i;code = 105
char = n;code = 110
char = ;code = 32
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char = M;code = 77
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char = e;code = 101
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char = k;code = 107
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char = n;code = 110
char = ;code = 32
char = t;code = 116
char = e;code = 101
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char = t;code = 116
char = ;code = 32
char = (;code = 40
char = M;code = 77
char = T;code = 84
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char = 8;code = 56
char = 7;code = 55
char = 2;code = 50
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char = ;;code = 59
char = M;code = 77
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char = f;code = 102
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char = h;code = 104
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char = ;code = 32
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char = i;code = 105
char = c;code = 99
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char = f;code = 102
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = u;code = 117
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char = s;code = 115
char = ;code = 32
char = o;code = 111
char = b;code = 98
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char = e;code = 101
char = r;code = 114
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char = e;code = 101
char = d;code = 100
char = ;code = 32
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char = n;code = 110
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char = a;code = 97
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char = L;code = 76
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char = H;code = 72
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char = A;code = 65
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char = C;code = 67
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char = N;code = 78
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char = 8;code = 56
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char = 2;code = 50
char = 3;code = 51
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char = 3;code = 51
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char = %;code = 37
char = H;code = 72
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char = 4;code = 52
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char = D;code = 68
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char = 5;code = 53
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char = a;code = 97
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char = I;code = 73
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char = .;code = 46
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char = W;code = 87
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char = 8;code = 56
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char = 6;code = 54
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result sql = In this study, we have analysed the phenotypic features of innate/adaptive immunity of patients with localized cutaneous leishmaniasis (LCL), categorized according to their clinical/laboratorial status, including number of lesion (L1; L2–4), days of illness duration (≤60;>60) and positivity in the Montenegro skin test (MT−;MT+). Our findings highlighted a range of phenotypic features observed in patients with LCL (↑%HLA-DR+ neutrophils; ↑CD8+ HLA-DR+/CD4+ HLA-DR+ T cell ratio; ↑HLA-DR in B lymphocytes, ↑%CD23+ neutrophils, monocytes and B cells; ↑α-Leishmania IgG and ↑serum NO₂⁻ + NO₃⁻). Selective changes were observed in L1 (↑%HLA-DR+ neutrophils, ↑CD8+ HLA-DR+/CD4+ HLA-DR+ T cell ratio and ↑serum NO₂⁻ + NO₃⁻) as compared to L2–4 (↑%CD5− B cells; ↑CD23+ B cells and ↑α-Leishmania IgG). Whilst ≤60 presented a mixed profile of innate/adaptive immunity (↓%CD28+ neutrophils and ↑%CD4+ T cells), >60 showed a well-known leishmanicidal events (↑CD8+ T cells; ↑serum NO₂⁻ + NO₃⁻ and ↑α-Leishmania IgG). MT+ patients showed increased putative leishmanicidal capacity (↑%HLA-DR+ neutrophils; ↑%CD23+ monocytes; ↑CD8+ HLA-DR+/CD4+ HLA-DR+ T cell ratio and ↑ serum NO₂⁻ + NO₃⁻). Overall, a range of immunological biomarkers illustrates the complex immunological network associated with distinct clinical/laboratorial features of LCL with applicability in clinical studies.

Publication: Scand. J. Immunol. 2012 Oct ;76(4)::421-32. :doi: 10.1111/j.1365-3083.2012.02748.x.
Publication Date: 2012 Oct
Study Author(s): Freitas-Teixeira, P M;Silveira-Lemos, D;Giunchetti, R C;Baratta-Masini, A;Mayrink, W;Peruhype-Magalhães, V;Rocha, R D R;Campi-Azevedo, A C;Teixeira-Carvalho, A;Martins-Filho, O A;
Institution: Laboratório de Biomarcadores de Diagnóstico e Monitoração, Centro de Pesquisas René Rachou, FIOCRUZ/Minas, Barro Preto, Belo Horizonte, MG, Brazil.
Shortcut link to this study:
In this study, we have analysed the phenotypic features of innate/adaptive immunity of patients with localized cutaneous leishmaniasis (LCL), categorized according to their clinical/laboratorial status, including number of lesion (L1; L2–4), days of illness duration (≤60;>60) and positivity in the Montenegro skin test (MT−;MT+). Our findings highlighted a range of phenotypic features observed in patients with LCL (↑%HLA-DR+ neutrophils; ↑CD8+ HLA-DR+/CD4+ HLA-DR+ T cell ratio; ↑HLA-DR in B lymphocytes, ↑%CD23+ neutrophils, monocytes and B cells; ↑α-Leishmania IgG and ↑serum NO₂⁻ + NO₃⁻). Selective changes were observed in L1 (↑%HLA-DR+ neutrophils, ↑CD8+ HLA-DR+/CD4+ HLA-DR+ T cell ratio and ↑serum NO₂⁻ + NO₃⁻) as compared to L2–4 (↑%CD5− B cells; ↑CD23+ B cells and ↑α-Leishmania IgG). Whilst ≤60 presented a mixed profile of innate/adaptive immunity (↓%CD28+ neutrophils and ↑%CD4+ T cells), >60 showed a well-known leishmanicidal events (↑CD8+ T cells; ↑serum NO₂⁻ + NO₃⁻ and ↑α-Leishmania IgG). MT+ patients showed increased putative leishmanicidal capacity (↑%HLA-DR+ neutrophils; ↑%CD23+ monocytes; ↑CD8+ HLA-DR+/CD4+ HLA-DR+ T cell ratio and ↑ serum NO₂⁻ + NO₃⁻). Overall, a range of immunological biomarkers illustrates the complex immunological network associated with distinct clinical/laboratorial features of LCL with applicability in clinical studies.
PMID: 22823491

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