|
|
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result sql = Amurensin G inhibits angiogenesis and tumor growth of tamoxifen-resistant breast cancer via Pin1 inhibition.
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char = W;code = 87
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char = s;code = 115
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char = d;code = 100
char = ;code = 32
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = s;code = 115
char = c;code = 99
char = r;code = 114
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char = p;code = 112
char = t;code = 116
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char = ;code = 32
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char = ;code = 32
char = i;code = 105
char = n;code = 110
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char = T;code = 84
char = A;code = 65
char = M;code = 77
char = R;code = 82
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char = M;code = 77
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char = l;code = 108
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char = c;code = 99
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char = e;code = 101
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char = e;code = 101
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char = d;code = 100
char = e;code = 101
char = n;code = 110
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char = n;code = 110
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char = F;code = 70
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char = h;code = 104
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char = i;code = 105
char = t;code = 116
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char = o;code = 111
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char = ;code = 32
char = C;code = 67
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char = i;code = 105
char = c;code = 99
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char = ;code = 32
char = c;code = 99
char = h;code = 104
char = o;code = 111
char = r;code = 114
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char = o;code = 111
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = o;code = 111
char = i;code = 105
char = c;code = 99
char = ;code = 32
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char = e;code = 101
char = m;code = 109
char = b;code = 98
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char = a;code = 97
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char = ;code = 32
char = a;code = 97
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char = s;code = 115
char = a;code = 97
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char = s;code = 115
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char = a;code = 97
char = t;code = 116
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char = i;code = 105
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char = g;code = 103
char = i;code = 105
char = o;code = 111
char = g;code = 103
char = e;code = 101
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char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
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char = i;code = 105
char = n;code = 110
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char = T;code = 84
char = M;code = 77
char = A;code = 65
char = R;code = 82
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char = M;code = 77
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char = F;code = 70
char = -;code = 45
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char = ;code = 32
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char = e;code = 101
char = ;code = 32
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char = s;code = 115
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = s;code = 115
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char = d;code = 100
char = e;code = 101
char = m;code = 109
char = o;code = 111
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char = r;code = 114
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char = t;code = 116
char = e;code = 101
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char = f;code = 102
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char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = f;code = 102
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char = s;code = 115
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char = t;code = 116
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char = m;code = 109
char = e;code = 101
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char = n;code = 110
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char = r;code = 114
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char = n;code = 110
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result sql = Acquired resistance to tamoxifen (TAM) is a serious therapeutic problem among estrogen-receptor-positive breast cancer patients. We have previously reported that TAM-resistant MCF-7 (TAMR-MCF-7) cells have elevated angiogenic potential via Pin1-dependent vascular endothelial growth factor (VEGF) production. Vitis amurensis grape consumed as wine and fruit contains several resveratrol-like stilbenes or oligostilbenes. In this study, we screened for the most active compound to inhibit VEGF production from V. amurensis. Among the tested compounds, amurensin G most potently suppressed VEGF production in TAMR-MCF-7 cells. The enhanced VEGF gene transcription in TAMR-MCF-7 cells was suppressed by amurensin G. Molecular analyses using reporter genes with hypoxia response elements and activator protein-1 (AP-1) elements, and western blots revealed that the activities and the nuclear levels of hypoxia inducible factor-1 (HIF-1)α and AP-1 in TAMR-MCF-7 cells were decreased by amurensin G. Moreover, amurensin G concentration-dependently inhibited protein expression and gene transcription of Pin1 in TAMR-MCF-7 cells, which was dependent on E2F1 inhibition. Chick chorioallantoic membrane assays confirmed that amurensin G had significant antiangiogenic and antitumor growth effects in TMAR-MCF-7 cells. These results demonstrate for the first time that amurensin G may have therapeutic potential for TAM-resistant breast cancer through blocking of Pin1-mediated VEGF gene transcription.
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char = e;code = 101
char = n;code = 110
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = G;code = 71
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = s;code = 115
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char = a;code = 97
char = n;code = 110
char = g;code = 103
char = i;code = 105
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
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char = d;code = 100
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char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
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char = ;code = 32
char = g;code = 103
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char = o;code = 111
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char = o;code = 111
char = f;code = 102
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char = a;code = 97
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char = i;code = 105
char = f;code = 102
char = e;code = 101
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char = a;code = 97
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char = b;code = 98
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char = t;code = 116
char = ;code = 32
char = c;code = 99
char = a;code = 97
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char = c;code = 99
char = e;code = 101
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char = v;code = 118
char = i;code = 105
char = a;code = 97
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char = P;code = 80
char = i;code = 105
char = n;code = 110
char = 1;code = 49
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
result sql = Amurensin G inhibits angiogenesis and tumor growth of tamoxifen-resistant breast cancer via Pin1 inhibition.
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char = u;code = 117
char = i;code = 105
char = r;code = 114
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char = r;code = 114
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char = i;code = 105
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char = s;code = 115
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char = t;code = 116
char = i;code = 105
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char = a;code = 97
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char = c;code = 99
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char = r;code = 114
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char = p;code = 112
char = a;code = 97
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char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
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char = ;code = 32
char = W;code = 87
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
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char = p;code = 112
char = r;code = 114
char = e;code = 101
char = v;code = 118
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char = o;code = 111
char = u;code = 117
char = s;code = 115
char = l;code = 108
char = y;code = 121
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char = r;code = 114
char = e;code = 101
char = p;code = 112
char = o;code = 111
char = r;code = 114
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
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char = T;code = 84
char = A;code = 65
char = M;code = 77
char = -;code = 45
char = r;code = 114
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char = s;code = 115
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = n;code = 110
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char = M;code = 77
char = C;code = 67
char = F;code = 70
char = -;code = 45
char = 7;code = 55
char = ;code = 32
char = (;code = 40
char = T;code = 84
char = A;code = 65
char = M;code = 77
char = R;code = 82
char = -;code = 45
char = M;code = 77
char = C;code = 67
char = F;code = 70
char = -;code = 45
char = 7;code = 55
char = );code = 41
char = ;code = 32
char = c;code = 99
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char = l;code = 108
char = s;code = 115
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char = a;code = 97
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char = e;code = 101
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char = e;code = 101
char = l;code = 108
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char = a;code = 97
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char = a;code = 97
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char = o;code = 111
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char = e;code = 101
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char = i;code = 105
char = c;code = 99
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char = p;code = 112
char = o;code = 111
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char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
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char = v;code = 118
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char = a;code = 97
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char = P;code = 80
char = i;code = 105
char = n;code = 110
char = 1;code = 49
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char = d;code = 100
char = e;code = 101
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char = e;code = 101
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char = d;code = 100
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = v;code = 118
char = a;code = 97
char = s;code = 115
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
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char = e;code = 101
char = n;code = 110
char = d;code = 100
char = o;code = 111
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char = h;code = 104
char = e;code = 101
char = l;code = 108
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = w;code = 119
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = f;code = 102
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = (;code = 40
char = V;code = 86
char = E;code = 69
char = G;code = 71
char = F;code = 70
char = );code = 41
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
char = ;code = 32
char = V;code = 86
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = m;code = 109
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = u;code = 117
char = m;code = 109
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = r;code = 114
char = u;code = 117
char = i;code = 105
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = o;code = 111
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char = t;code = 116
char = a;code = 97
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char = n;code = 110
char = s;code = 115
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char = s;code = 115
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = l;code = 108
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char = r;code = 114
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char = s;code = 115
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char = e;code = 101
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = r;code = 114
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char = l;code = 108
char = -;code = 45
char = l;code = 108
char = i;code = 105
char = k;code = 107
char = e;code = 101
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char = i;code = 105
char = l;code = 108
char = b;code = 98
char = e;code = 101
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char = e;code = 101
char = s;code = 115
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char = o;code = 111
char = r;code = 114
char = ;code = 32
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = g;code = 103
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char = s;code = 115
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char = l;code = 108
char = b;code = 98
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char = n;code = 110
char = e;code = 101
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char = I;code = 73
char = n;code = 110
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char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
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char = s;code = 115
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char = s;code = 115
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char = e;code = 101
char = e;code = 101
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = m;code = 109
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char = s;code = 115
char = t;code = 116
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char = a;code = 97
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char = p;code = 112
char = o;code = 111
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char = t;code = 116
char = o;code = 111
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char = i;code = 105
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char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
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char = V;code = 86
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char = G;code = 71
char = F;code = 70
char = ;code = 32
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char = u;code = 117
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char = o;code = 111
char = n;code = 110
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char = r;code = 114
char = o;code = 111
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char = V;code = 86
char = .;code = 46
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char = a;code = 97
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char = u;code = 117
char = r;code = 114
char = e;code = 101
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char = s;code = 115
char = .;code = 46
char = ;code = 32
char = A;code = 65
char = m;code = 109
char = o;code = 111
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char = ;code = 32
char = t;code = 116
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char = i;code = 105
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char = s;code = 115
char = e;code = 101
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char = V;code = 86
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char = i;code = 105
char = n;code = 110
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char = T;code = 84
char = A;code = 65
char = M;code = 77
char = R;code = 82
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char = M;code = 77
char = C;code = 67
char = F;code = 70
char = -;code = 45
char = 7;code = 55
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char = l;code = 108
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char = .;code = 46
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char = T;code = 84
char = h;code = 104
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char = a;code = 97
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char = F;code = 70
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char = g;code = 103
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char = a;code = 97
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char = i;code = 105
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char = i;code = 105
char = n;code = 110
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char = T;code = 84
char = A;code = 65
char = M;code = 77
char = R;code = 82
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char = M;code = 77
char = C;code = 67
char = F;code = 70
char = -;code = 45
char = 7;code = 55
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char = c;code = 99
char = e;code = 101
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char = l;code = 108
char = s;code = 115
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char = w;code = 119
char = a;code = 97
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char = s;code = 115
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char = p;code = 112
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char = e;code = 101
char = d;code = 100
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char = b;code = 98
char = y;code = 121
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char = u;code = 117
char = r;code = 114
char = e;code = 101
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char = i;code = 105
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char = G;code = 71
char = .;code = 46
char = ;code = 32
char = M;code = 77
char = o;code = 111
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char = e;code = 101
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char = u;code = 117
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char = a;code = 97
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char = s;code = 115
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char = o;code = 111
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char = e;code = 101
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char = A;code = 65
char = P;code = 80
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char = e;code = 101
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char = e;code = 101
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char = e;code = 101
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char = e;code = 101
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char = f;code = 102
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char = f;code = 102
char = a;code = 97
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char = t;code = 116
char = o;code = 111
char = r;code = 114
char = -;code = 45
char = 1;code = 49
char = ;code = 32
char = (;code = 40
char = H;code = 72
char = I;code = 73
char = F;code = 70
char = -;code = 45
char = 1;code = 49
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char = &;code = 38
char = #;code = 35
char = 9;code = 57
char = 4;code = 52
char = 5;code = 53
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char = d;code = 100
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char = A;code = 65
char = P;code = 80
char = -;code = 45
char = 1;code = 49
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char = i;code = 105
char = n;code = 110
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char = T;code = 84
char = A;code = 65
char = M;code = 77
char = R;code = 82
char = -;code = 45
char = M;code = 77
char = C;code = 67
char = F;code = 70
char = -;code = 45
char = 7;code = 55
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char = c;code = 99
char = e;code = 101
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char = l;code = 108
char = s;code = 115
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char = r;code = 114
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char = a;code = 97
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char = u;code = 117
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char = n;code = 110
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char = i;code = 105
char = n;code = 110
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char = G;code = 71
char = .;code = 46
char = ;code = 32
char = M;code = 77
char = o;code = 111
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result sql = Acquired resistance to tamoxifen (TAM) is a serious therapeutic problem among estrogen-receptor-positive breast cancer patients. We have previously reported that TAM-resistant MCF-7 (TAMR-MCF-7) cells have elevated angiogenic potential via Pin1-dependent vascular endothelial growth factor (VEGF) production. Vitis amurensis grape consumed as wine and fruit contains several resveratrol-like stilbenes or oligostilbenes. In this study, we screened for the most active compound to inhibit VEGF production from V. amurensis. Among the tested compounds, amurensin G most potently suppressed VEGF production in TAMR-MCF-7 cells. The enhanced VEGF gene transcription in TAMR-MCF-7 cells was suppressed by amurensin G. Molecular analyses using reporter genes with hypoxia response elements and activator protein-1 (AP-1) elements, and western blots revealed that the activities and the nuclear levels of hypoxia inducible factor-1 (HIF-1)α and AP-1 in TAMR-MCF-7 cells were decreased by amurensin G. Moreover, amurensin G concentration-dependently inhibited protein expression and gene transcription of Pin1 in TAMR-MCF-7 cells, which was dependent on E2F1 inhibition. Chick chorioallantoic membrane assays confirmed that amurensin G had significant antiangiogenic and antitumor growth effects in TMAR-MCF-7 cells. These results demonstrate for the first time that amurensin G may have therapeutic potential for TAM-resistant breast cancer through blocking of Pin1-mediated VEGF gene transcription.
Publication: Food Chem. Toxicol. 2012 Oct ;50(10)::3625-34. :doi: 10.1016/j.fct.2012.07.027. :pii: S0278-6915(12)00505-4.
Publication Date: 2012 Oct
Study Author(s): Kim, Jung-Ae;Kim, Mi Ra;Kim, Ok;Phuong, Nguyen Thi Thuy;Yun, Jieun;Yoon, Jieun;Oh, Won Keun;Bae, KiHwan;Kang, Keon Wook;
Institution: College of Pharmacy, Yeungnam University, Daegu 712-749, Republic of Korea.
Shortcut link to this study:
Publication Date: 2012 Oct
Study Author(s): Kim, Jung-Ae;Kim, Mi Ra;Kim, Ok;Phuong, Nguyen Thi Thuy;Yun, Jieun;Yoon, Jieun;Oh, Won Keun;Bae, KiHwan;Kang, Keon Wook;
Institution: College of Pharmacy, Yeungnam University, Daegu 712-749, Republic of Korea.
Shortcut link to this study:
Acquired resistance to tamoxifen (TAM) is a serious therapeutic problem among estrogen-receptor-positive breast cancer patients. We have previously reported that TAM-resistant MCF-7 (TAMR-MCF-7) cells have elevated angiogenic potential via Pin1-dependent vascular endothelial growth factor (VEGF) production. Vitis amurensis grape consumed as wine and fruit contains several resveratrol-like stilbenes or oligostilbenes. In this study, we screened for the most active compound to inhibit VEGF production from V. amurensis. Among the tested compounds, amurensin G most potently suppressed VEGF production in TAMR-MCF-7 cells. The enhanced VEGF gene transcription in TAMR-MCF-7 cells was suppressed by amurensin G. Molecular analyses using reporter genes with hypoxia response elements and activator protein-1 (AP-1) elements, and western blots revealed that the activities and the nuclear levels of hypoxia inducible factor-1 (HIF-1)α and AP-1 in TAMR-MCF-7 cells were decreased by amurensin G. Moreover, amurensin G concentration-dependently inhibited protein expression and gene transcription of Pin1 in TAMR-MCF-7 cells, which was dependent on E2F1 inhibition. Chick chorioallantoic membrane assays confirmed that amurensin G had significant antiangiogenic and antitumor growth effects in TMAR-MCF-7 cells. These results demonstrate for the first time that amurensin G may have therapeutic potential for TAM-resistant breast cancer through blocking of Pin1-mediated VEGF gene transcription.
PMID: 22842120
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