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result sql = Corneal collagen cross-linking window absorption.
Corneal collagen cross-linking window absorption.
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result sql = PURPOSE : To evaluate the safety and efficacy of treatment of severe infectious corneal ulcers with hypoosmolar riboflavin solution and UV-A collagen cross-linking (CXL) without deepithelizing the cornea.

METHODS : Four eyes of 3 patients with severe keratitis and associated corneal melting, were treated with a new protocol of corneal CXL for infectious keratitis, named cross-linking window absorption (CXL-WA). CXL-WA was performed when the infection did not respond to systemic and topical antibiotic therapy. The protocol entails the use of hypoosmolar riboflavin before the irradiation with UV-A, and the penetration is obtained through the epithelial defect overlying the ulcer.

RESULTS : In all cases, CXL halted the progression of the ulcer. After a minimum follow-up of 3 months, none of the patients had recurrence of the infection.

CONCLUSION : CXL-WA is a promising technique of treatment of infectious corneal ulcers, delaying or preventing more invasive approaches.

Publication: Cornea 2013 Apr ;32(4)::550-4. :doi: 10.1097/ICO.0b013e318259c9bb.
Publication Date: 2013 Apr
Study Author(s): Rosetta, Pietro;Vinciguerra, Riccardo;Romano, Mario R;Vinciguerra, Paolo;
Institution: Department of Ophthalmology, Istituto Clinico Humanitas, Milan, Italy.
Shortcut link to this study:
PURPOSE : To evaluate the safety and efficacy of treatment of severe infectious corneal ulcers with hypoosmolar riboflavin solution and UV-A collagen cross-linking (CXL) without deepithelizing the cornea.

METHODS : Four eyes of 3 patients with severe keratitis and associated corneal melting, were treated with a new protocol of corneal CXL for infectious keratitis, named cross-linking window absorption (CXL-WA). CXL-WA was performed when the infection did not respond to systemic and topical antibiotic therapy. The protocol entails the use of hypoosmolar riboflavin before the irradiation with UV-A, and the penetration is obtained through the epithelial defect overlying the ulcer.

RESULTS : In all cases, CXL halted the progression of the ulcer. After a minimum follow-up of 3 months, none of the patients had recurrence of the infection.

CONCLUSION : CXL-WA is a promising technique of treatment of infectious corneal ulcers, delaying or preventing more invasive approaches.
PMID: 22895045

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