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result sql = Synthesis and evaluation of novel 1,3,4-oxadiazole derivatives of marine bromopyrrole alkaloids as antimicrobial agent.
Synthesis and evaluation of novel 1,3,4-oxadiazole derivatives of marine bromopyrrole alkaloids as antimicrobial agent.
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char = t;code = 116
char = ;code = 32
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char = s;code = 115
char = ;code = 32
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char = e;code = 101
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char = d;code = 100
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char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = v;code = 118
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char = m;code = 109
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char = ;code = 32
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char = i;code = 105
char = -;code = 45
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char = B;code = 66
char = ;code = 32
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char = o;code = 111
char = m;code = 109
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char = o;code = 111
char = u;code = 117
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result sql = In an attempt to identify new potential lead as antimicrobial agent, twenty hybrids of marine bromopyrrole alkaloids with 1,3,4-oxadiazole were designed based on molecular hybridization technique and synthesized. Synthesized molecules were evaluated for their antibacterial, antifungal and antitubercular activities. Hybrids 5d, 5i, 5j and 5k exhibited equivalent antibacterial activity (MIC of 1.56 μg/mL) compared with standard drug ciprofloxacin against Staphylococcus aureus and Escherichia coli. Equal antifungal activity (MIC of 1.56 μg/mL) was shown by of hybrids 5j, 5k and 7d compared with standard Amphotericin-B. The inhibition of Mycobacterium tuberculosis at concentrations as low as 1.6 and 1.5 μg/mL by compounds 5f and 7d respectively indicates that these compounds can act as leads for development of newer anti-TB compounds.

Publication: Bioorg. Med. Chem. Lett. 2012 Oct 15 ;22(20)::6429-32. :doi: 10.1016/j.bmcl.2012.08.061. :pii: S0960-894X(12)01072-4.
Publication Date: 2012 Oct 15
Study Author(s): Rane, Rajesh A;Gutte, Shweta D;Sahu, Niteshkumar U;
Institution: SPP School of Pharmacy and Technology Management, NMIMS University, Vile Parle, Mumbai, India. rajeshrane_uict@yahoo.co.in
Shortcut link to this study:

In an attempt to identify new potential lead as antimicrobial agent, twenty hybrids of marine bromopyrrole alkaloids with 1,3,4-oxadiazole were designed based on molecular hybridization technique and synthesized. Synthesized molecules were evaluated for their antibacterial, antifungal and antitubercular activities. Hybrids 5d, 5i, 5j and 5k exhibited equivalent antibacterial activity (MIC of 1.56 μg/mL) compared with standard drug ciprofloxacin against Staphylococcus aureus and Escherichia coli. Equal antifungal activity (MIC of 1.56 μg/mL) was shown by of hybrids 5j, 5k and 7d compared with standard Amphotericin-B. The inhibition of Mycobacterium tuberculosis at concentrations as low as 1.6 and 1.5 μg/mL by compounds 5f and 7d respectively indicates that these compounds can act as leads for development of newer anti-TB compounds.

PMID: 22967765

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