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|
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result sql = Synthesis and biological evaluation of nitrogen mustard derivatives of purine bases.
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result sql = This paper deals with the synthesis of nitrogen mustard analogs, derivatives of purine bases. Alkylation in position N-9 and diethanolamine fixation on position 6 were managed by microwave irradiations. Chlorination of these dihydroxylated intermediates led to a cyclization, giving tricyclic purine base analogs bearing a chloroethyl chain. Finally, MTT assays on obtained compounds do not show cytotoxicity on four different cancer cell lines.
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result sql = Synthesis and biological evaluation of nitrogen mustard derivatives of purine bases.
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result sql = This paper deals with the synthesis of nitrogen mustard analogs, derivatives of purine bases. Alkylation in position N-9 and diethanolamine fixation on position 6 were managed by microwave irradiations. Chlorination of these dihydroxylated intermediates led to a cyclization, giving tricyclic purine base analogs bearing a chloroethyl chain. Finally, MTT assays on obtained compounds do not show cytotoxicity on four different cancer cell lines.
Publication: Nucleosides Nucleotides Nucleic Acids 2013 ;32(2)::69-80. :doi: 10.1080/15257770.2013.763977.
Publication Date: 2013
Study Author(s): Boëns, Benjamin;Azouz, Mounir;Ouk, Tan-Sothea;Zerrouki, Rachida;
Institution: Laboratoire de Chimie des Substances Naturelles, Limoges, France.
Shortcut link to this study:
Publication Date: 2013
Study Author(s): Boëns, Benjamin;Azouz, Mounir;Ouk, Tan-Sothea;Zerrouki, Rachida;
Institution: Laboratoire de Chimie des Substances Naturelles, Limoges, France.
Shortcut link to this study:
This paper deals with the synthesis of nitrogen mustard analogs, derivatives of purine bases. Alkylation in position N-9 and diethanolamine fixation on position 6 were managed by microwave irradiations. Chlorination of these dihydroxylated intermediates led to a cyclization, giving tricyclic purine base analogs bearing a chloroethyl chain. Finally, MTT assays on obtained compounds do not show cytotoxicity on four different cancer cell lines.
PMID: 23448142
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