char = [;code = 91 char = N;code = 78 char = a;code = 97 char = t;code = 116 char = a;code = 97 char = m;code = 109 char = y;code = 121 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = (;code = 40 char = p;code = 112 char = i;code = 105 char = m;code = 109 char = a;code = 97 char = r;code = 114 char = i;code = 105 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = );code = 41 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = e;code = 101 char = x;code = 120 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = k;code = 107 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = o;code = 111 char = m;code = 109 char = y;code = 121 char = c;code = 99 char = o;code = 111 char = s;code = 115 char = i;code = 105 char = s;code = 115 char = ];code = 93 char = .;code = 46 result sql = [Natamycin (pimaricin) in the treatment of experimental keratomycosis].
[Natamycin (pimaricin) in the treatment of experimental keratomycosis].char = T;code = 84 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = e;code = 101 char = f;code = 102 char = f;code = 102 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = c;code = 99 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = n;code = 110 char = a;code = 97 char = t;code = 116 char = a;code = 97 char = m;code = 109 char = y;code = 121 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = (;code = 40 char = p;code = 112 char = i;code = 105 char = m;code = 109 char = a;code = 97 char = r;code = 114 char = i;code = 105 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = );code = 41 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = u;code = 117 char = d;code = 100 char = i;code = 105 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = p;code = 112 char = a;code = 97 char = r;code = 114 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = a;code = 97 char = r;code = 114 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = m;code = 109 char = p;code = 112 char = h;code = 104 char = o;code = 111 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = B;code = 66 char = ,;code = 44 char = ;code = 32 char = u;code = 117 char = s;code = 115 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = p;code = 112 char = r;code = 114 char = o;code = 111 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = i;code = 105 char = b;code = 98 char = l;code = 108 char = e;code = 101 char = ;code = 32 char = m;code = 109 char = o;code = 111 char = d;code = 100 char = e;code = 101 char = l;code = 108 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = k;code = 107 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = o;code = 111 char = m;code = 109 char = y;code = 121 char = c;code = 99 char = o;code = 111 char = s;code = 115 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = f;code = 102 char = r;code = 114 char = o;code = 111 char = m;code = 109 char = ;code = 32 char = C;code = 67 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = i;code = 105 char = d;code = 100 char = a;code = 97 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = b;code = 98 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = b;code = 98 char = b;code = 98 char = i;code = 105 char = t;code = 116 char = .;code = 46 char = ;code = 32 char = C;code = 67 char = .;code = 46 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = b;code = 98 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = D;code = 68 char = S;code = 83 char = M;code = 77 char = ;code = 32 char = 7;code = 55 char = 0;code = 48 char = 0;code = 48 char = 1;code = 49 char = 0;code = 48 char = ;code = 32 char = (;code = 40 char = 2;code = 50 char = .;code = 46 char = 5;code = 53 char = ;code = 32 char = X;code = 88 char = ;code = 32 char = 1;code = 49 char = 0;code = 48 char = (;code = 40 char = 5;code = 53 char = );code = 41 char = ;code = 32 char = c;code = 99 char = e;code = 101 char = l;code = 108 char = l;code = 108 char = s;code = 115 char = );code = 41 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = j;code = 106 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = r;code = 114 char = n;code = 110 char = e;code = 101 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = m;code = 109 char = a;code = 97 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = b;code = 98 char = o;code = 111 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = e;code = 101 char = y;code = 121 char = e;code = 101 char = s;code = 115 char = .;code = 46 char = ;code = 32 char = A;code = 65 char = l;code = 108 char = l;code = 108 char = ;code = 32 char = e;code = 101 char = y;code = 121 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = v;code = 118 char = e;code = 101 char = l;code = 108 char = o;code = 111 char = p;code = 112 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = r;code = 114 char = n;code = 110 char = e;code = 101 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = u;code = 117 char = l;code = 108 char = c;code = 99 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = o;code = 111 char = u;code = 117 char = t;code = 116 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = i;code = 105 char = m;code = 109 char = m;code = 109 char = u;code = 117 char = n;code = 110 char = o;code = 111 char = s;code = 115 char = u;code = 117 char = p;code = 112 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = s;code = 115 char = i;code = 105 char = v;code = 118 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = g;code = 103 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = s;code = 115 char = .;code = 46 char = ;code = 32 char = F;code = 70 char = o;code = 111 char = r;code = 114 char = t;code = 116 char = y;code = 121 char = -;code = 45 char = e;code = 101 char = i;code = 105 char = g;code = 103 char = h;code = 104 char = t;code = 116 char = ;code = 32 char = h;code = 104 char = o;code = 111 char = u;code = 117 char = r;code = 114 char = s;code = 115 char = ;code = 32 char = a;code = 97 char = f;code = 102 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = o;code = 111 char = c;code = 99 char = u;code = 117 char = l;code = 108 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ,;code = 44 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = i;code = 105 char = m;code = 109 char = a;code = 97 char = l;code = 108 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = d;code = 100 char = i;code = 105 char = v;code = 118 char = i;code = 105 char = d;code = 100 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = f;code = 102 char = i;code = 105 char = v;code = 118 char = e;code = 101 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = s;code = 115 char = :;code = 58 char = ;code = 32 char = I;code = 73 char = ;code = 32 char = (;code = 40 char = 1;code = 49 char = 0;code = 48 char = ;code = 32 char = e;code = 101 char = y;code = 121 char = e;code = 101 char = s;code = 115 char = );code = 41 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = I;code = 73 char = I;code = 73 char = ;code = 32 char = (;code = 40 char = 1;code = 49 char = 2;code = 50 char = ;code = 32 char = e;code = 101 char = y;code = 121 char = e;code = 101 char = s;code = 115 char = );code = 41 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = c;code = 99 char = e;code = 101 char = i;code = 105 char = v;code = 118 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = n;code = 110 char = a;code = 97 char = t;code = 116 char = a;code = 97 char = m;code = 109 char = y;code = 121 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = d;code = 100 char = r;code = 114 char = o;code = 111 char = p;code = 112 char = s;code = 115 char = ,;code = 44 char = ;code = 32 char = 1;code = 49 char = %;code = 37 char = ;;code = 59 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = s;code = 115 char = ;code = 32 char = I;code = 73 char = I;code = 73 char = I;code = 73 char = ;code = 32 char = (;code = 40 char = 1;code = 49 char = 2;code = 50 char = ;code = 32 char = e;code = 101 char = y;code = 121 char = e;code = 101 char = s;code = 115 char = );code = 41 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = I;code = 73 char = V;code = 86 char = ;code = 32 char = (;code = 40 char = 1;code = 49 char = 2;code = 50 char = ;code = 32 char = e;code = 101 char = y;code = 121 char = e;code = 101 char = s;code = 115 char = );code = 41 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = c;code = 99 char = e;code = 101 char = i;code = 105 char = v;code = 118 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = n;code = 110 char = a;code = 97 char = t;code = 116 char = a;code = 97 char = m;code = 109 char = y;code = 121 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = ,;code = 44 char = ;code = 32 char = 2;code = 50 char = .;code = 46 char = 5;code = 53 char = %;code = 37 char = ;;code = 59 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = l;code = 108 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = ;code = 32 char = (;code = 40 char = 1;code = 49 char = 4;code = 52 char = ;code = 32 char = e;code = 101 char = y;code = 121 char = e;code = 101 char = s;code = 115 char = );code = 41 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = c;code = 99 char = e;code = 101 char = i;code = 105 char = v;code = 118 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = 0;code = 48 char = .;code = 46 char = 9;code = 57 char = %;code = 37 char = ;code = 32 char = N;code = 78 char = a;code = 97 char = C;code = 67 char = l;code = 108 char = .;code = 46 char = ;code = 32 char = F;code = 70 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = b;code = 98 char = e;code = 101 char = t;code = 116 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = p;code = 112 char = e;code = 101 char = n;code = 110 char = e;code = 101 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = d;code = 100 char = r;code = 114 char = u;code = 117 char = g;code = 103 char = ,;code = 44 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = e;code = 101 char = p;code = 112 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = l;code = 108 char = i;code = 105 char = u;code = 117 char = m;code = 109 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = s;code = 115 char = ;code = 32 char = I;code = 73 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = I;code = 73 char = I;code = 73 char = I;code = 73 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = m;code = 109 char = o;code = 111 char = v;code = 118 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = e;code = 101 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = y;code = 121 char = ;code = 32 char = 3;code = 51 char = r;code = 114 char = d;code = 100 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = .;code = 46 char = ;code = 32 char = H;code = 72 char = a;code = 97 char = l;code = 108 char = f;code = 102 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = l;code = 108 char = ;code = 32 char = g;code = 103 char = r;code = 114 char = o;code = 111 char = u;code = 117 char = p;code = 112 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = d;code = 100 char = e;code = 101 char = b;code = 98 char = r;code = 114 char = i;code = 105 char = d;code = 100 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = l;code = 108 char = l;code = 108 char = .;code = 46 char = ;code = 32 char = I;code = 73 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = ;code = 32 char = f;code = 102 char = u;code = 117 char = r;code = 114 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = e;code = 101 char = s;code = 115 char = ,;code = 44 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = e;code = 101 char = n;code = 110 char = e;code = 101 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = n;code = 110 char = a;code = 97 char = t;code = 116 char = a;code = 97 char = m;code = 109 char = y;code = 121 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = r;code = 114 char = n;code = 110 char = e;code = 101 char = a;code = 97 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = q;code = 113 char = u;code = 117 char = e;code = 101 char = o;code = 111 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = h;code = 104 char = u;code = 117 char = m;code = 109 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = u;code = 117 char = d;code = 100 char = i;code = 105 char = e;code = 101 char = d;code = 100 char = .;code = 46 char = ;code = 32 char = T;code = 84 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = n;code = 110 char = o;code = 111 char = ;code = 32 char = d;code = 100 char = i;code = 105 char = f;code = 102 char = f;code = 102 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = b;code = 98 char = e;code = 101 char = t;code = 116 char = w;code = 119 char = e;code = 101 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = e;code = 101 char = y;code = 121 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = l;code = 108 char = ;code = 32 char = e;code = 101 char = y;code = 121 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = r;code = 114 char = n;code = 110 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = m;code = 109 char = p;code = 112 char = l;code = 108 char = i;code = 105 char = c;code = 99 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = d;code = 100 char = e;code = 101 char = s;code = 115 char = c;code = 99 char = e;code = 101 char = m;code = 109 char = e;code = 101 char = t;code = 116 char = o;code = 111 char = c;code = 99 char = e;code = 101 char = l;code = 108 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = );code = 41 char = .;code = 46 char = ;code = 32 char = I;code = 73 char = t;code = 116 char = ;code = 32 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = c;code = 99 char = l;code = 108 char = u;code = 117 char = d;code = 100 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = a;code = 97 char = t;code = 116 char = ;code = 32 char = n;code = 110 char = a;code = 97 char = t;code = 116 char = a;code = 97 char = m;code = 109 char = y;code = 121 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = (;code = 40 char = p;code = 112 char = i;code = 105 char = m;code = 109 char = a;code = 97 char = r;code = 114 char = i;code = 105 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = );code = 41 char = ;code = 32 char = i;code = 105 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = f;code = 102 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = a;code = 97 char = m;code = 109 char = p;code = 112 char = h;code = 104 char = o;code = 111 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = c;code = 99 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = B;code = 66 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = n;code = 110 char = o;code = 111 char = t;code = 116 char = ;code = 32 char = e;code = 101 char = f;code = 102 char = f;code = 102 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = v;code = 118 char = e;code = 101 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = l;code = 108 char = l;code = 108 char = i;code = 105 char = n;code = 110 char = g;code = 103 char = ;code = 32 char = e;code = 101 char = x;code = 120 char = p;code = 112 char = e;code = 101 char = r;code = 114 char = i;code = 105 char = m;code = 109 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = a;code = 97 char = l;code = 108 char = ;code = 32 char = k;code = 107 char = e;code = 101 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = o;code = 111 char = m;code = 109 char = y;code = 121 char = c;code = 99 char = o;code = 111 char = s;code = 115 char = i;code = 105 char = s;code = 115 char = .;code = 46 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 result sql = The efficacy of natamycin (pimaricin) was studied and compared with the standard amphotericin B, using a reproducible model of keratomycosis from Candida albicans in the rabbit. C. albicans DSM 70010 (2.5 X 10(5) cells) was injected into the corneal stroma of both eyes. All eyes developed a corneal ulcer without pretreatment with immunosuppressive agents. Forty-eight hours after inoculation, the animals were divided into five groups: I (10 eyes) and II (12 eyes) receiving natamycin drops, 1%; groups III (12 eyes) and IV (12 eyes) receiving natamycin, 2.5%; the control group (14 eyes) receiving 0.9% NaCl. For better penetration of the drug, the epithelium of groups I and III was removed every 3rd day. Half of the control group was debrided as well. In a further series, the penetration of natamycin into the cornea and aqueous humor was studied. There was no difference between the treated eyes and the control eyes concerning complications (descemetocele or perforation). It is concluded that natamycin (pimaricin) is inferior to amphotericin B and not effective in controlling experimental keratomycosis.
Publication: Fortschr Ophthalmol 1990 ;87(3)::237-40.
Publication Date: 1990
Study Author(s): Behrens-Baumann, W;Klinge, B;
Institution: Abteilung Augenheilkunde, Universitäts-Augenklinik, Göttingen.
Shortcut link to this study:
The efficacy of natamycin (pimaricin) was studied and compared with the standard amphotericin B, using a reproducible model of keratomycosis from Candida albicans in the rabbit. C. albicans DSM 70010 (2.5 X 10(5) cells) was injected into the corneal stroma of both eyes. All eyes developed a corneal ulcer without pretreatment with immunosuppressive agents. Forty-eight hours after inoculation, the animals were divided into five groups: I (10 eyes) and II (12 eyes) receiving natamycin drops, 1%; groups III (12 eyes) and IV (12 eyes) receiving natamycin, 2.5%; the control group (14 eyes) receiving 0.9% NaCl. For better penetration of the drug, the epithelium of groups I and III was removed every 3rd day. Half of the control group was debrided as well. In a further series, the penetration of natamycin into the cornea and aqueous humor was studied. There was no difference between the treated eyes and the control eyes concerning complications (descemetocele or perforation). It is concluded that natamycin (pimaricin) is inferior to amphotericin B and not effective in controlling experimental keratomycosis.
PMID: 2376371