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result sql = Magnesium bioavailability from magnesium citrate and magnesium oxide.
Magnesium bioavailability from magnesium citrate and magnesium oxide.
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char = s;code = 115
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char = s;code = 115
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char = s;code = 115
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char = m;code = 109
char = e;code = 101
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char = s;code = 115
char = u;code = 117
char = r;code = 114
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char = d;code = 100
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char = i;code = 105
char = v;code = 118
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char = i;code = 105
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char = ;code = 32
char = n;code = 110
char = o;code = 111
char = r;code = 114
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char = ;code = 32
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char = t;code = 116
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char = s;code = 115
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char = s;code = 115
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char = f;code = 102
char = i;code = 105
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char = n;code = 110
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char = ;code = 32
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char = i;code = 105
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char = h;code = 104
char = e;code = 101
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char = h;code = 104
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char = h;code = 104
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char = ;code = 32
char = l;code = 108
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char = d;code = 100
char = ;code = 32
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char = ;code = 32
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char = r;code = 114
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char = o;code = 111
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char = ;code = 32
char = 0;code = 48
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char = 2;code = 50
char = ;code = 32
char = v;code = 118
char = s;code = 115
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
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char = 6;code = 54
char = ;code = 32
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char = m;code = 109
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char = i;code = 105
char = n;code = 110
char = e;code = 101
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char = ;code = 32
char = p;code = 112
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char = e;code = 101
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char = s;code = 115
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char = a;code = 97
char = n;code = 110
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char = .;code = 46
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char = 5;code = 53
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char = ;code = 32
char = d;code = 100
char = u;code = 117
char = r;code = 114
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char = n;code = 110
char = g;code = 103
char = ;code = 32
char = s;code = 115
char = e;code = 101
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = d;code = 100
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char = ;code = 32
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char = o;code = 111
char = u;code = 117
char = r;code = 114
char = s;code = 115
char = ;code = 32
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char = o;code = 111
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char = o;code = 111
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char = d;code = 100
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char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 3;code = 51
char = 5;code = 53
char = ;code = 32
char = v;code = 118
char = s;code = 115
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 0;code = 48
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char = ;code = 32
char = m;code = 109
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char = m;code = 109
char = g;code = 103
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char = r;code = 114
char = e;code = 101
char = a;code = 97
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char = n;code = 110
char = i;code = 105
char = n;code = 110
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char = ,;code = 44
char = ;code = 32
char = p;code = 112
char = ;code = 32
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char = e;code = 101
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char = s;code = 115
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char = h;code = 104
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char = n;code = 110
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char = 0;code = 48
char = .;code = 46
char = 0;code = 48
char = 5;code = 53
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char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = u;code = 117
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = g;code = 103
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = c;code = 99
char = i;code = 105
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = o;code = 111
char = l;code = 108
char = u;code = 117
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = i;code = 105
char = o;code = 111
char = a;code = 97
char = v;code = 118
char = a;code = 97
char = i;code = 105
char = l;code = 108
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = g;code = 103
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = .;code = 46
char = <;code = 60
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char = r;code = 114
char = /;code = 47
char = >;code = 62
result sql = This study compared magnesium oxide and magnesium citrate with respect to in vitro solubility and in vivo gastrointestinal absorbability. The solubility of 25 mmol magnesium citrate and magnesium oxide was examined in vitro in solutions containing varying amounts of hydrochloric acid (0-24.2 mEq) in 300 ml distilled water intended to mimic achlorhydric to peak acid secretory states. Magnesium oxide was virtually insoluble in water and only 43% soluble in simulated peak acid secretion (24.2 mEq hydrochloric acid/300 ml). Magnesium citrate had high solubility even in water (55%) and was substantially more soluble than magnesium oxide in all states of acid secretion. Reprecipitation of magnesium citrate and magnesium oxide did not occur when the filtrates from the solubility studies were titrated to pH 6 and 7 to stimulate pancreatic bicarbonate secretion. Approximately 65% of magnesium citrate was complexed as soluble magnesium citrate, whereas magnesium complexation was not present in the magnesium oxide system. Magnesium absorption from the two magnesium salts was measured in vivo in normal volunteers by assessing the rise in urinary magnesium following oral magnesium load. The increment in urinary magnesium following magnesium citrate load (25 mmol) was significantly higher than that obtained from magnesium oxide load (during 4 hours post-load, 0.22 vs 0.006 mg/mg creatinine, p less than 0.05; during second 2 hours post-load, 0.035 vs 0.008 mg/mg creatinine, p less than 0.05). Thus, magnesium citrate was more soluble and bioavailable than magnesium oxide.

Publication: J Am Coll Nutr 1990 Feb ;9(1)::48-55.
Publication Date: 1990 Feb
Study Author(s): Lindberg, J S;Zobitz, M M;Poindexter, J R;Pak, C Y;
Institution: Center for Mineral Metabolism and Clinical Research, University of Texas, Southwestern Medical Center, Dallas 75235.
Shortcut link to this study:
This study compared magnesium oxide and magnesium citrate with respect to in vitro solubility and in vivo gastrointestinal absorbability. The solubility of 25 mmol magnesium citrate and magnesium oxide was examined in vitro in solutions containing varying amounts of hydrochloric acid (0-24.2 mEq) in 300 ml distilled water intended to mimic achlorhydric to peak acid secretory states. Magnesium oxide was virtually insoluble in water and only 43% soluble in simulated peak acid secretion (24.2 mEq hydrochloric acid/300 ml). Magnesium citrate had high solubility even in water (55%) and was substantially more soluble than magnesium oxide in all states of acid secretion. Reprecipitation of magnesium citrate and magnesium oxide did not occur when the filtrates from the solubility studies were titrated to pH 6 and 7 to stimulate pancreatic bicarbonate secretion. Approximately 65% of magnesium citrate was complexed as soluble magnesium citrate, whereas magnesium complexation was not present in the magnesium oxide system. Magnesium absorption from the two magnesium salts was measured in vivo in normal volunteers by assessing the rise in urinary magnesium following oral magnesium load. The increment in urinary magnesium following magnesium citrate load (25 mmol) was significantly higher than that obtained from magnesium oxide load (during 4 hours post-load, 0.22 vs 0.006 mg/mg creatinine, p less than 0.05; during second 2 hours post-load, 0.035 vs 0.008 mg/mg creatinine, p less than 0.05). Thus, magnesium citrate was more soluble and bioavailable than magnesium oxide.
PMID: 2407766

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