|
|
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char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
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char = C;code = 67
char = a;code = 97
char = 2;code = 50
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char = i;code = 105
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char = t;code = 116
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char = N;code = 78
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char = H;code = 72
char = +;code = 43
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char = g;code = 103
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char = l;code = 108
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char = f;code = 102
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char = r;code = 114
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
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char = e;code = 101
char = d;code = 100
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char = y;code = 121
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char = o;code = 111
char = r;code = 114
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char = o;code = 111
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char = e;code = 101
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = r;code = 114
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char = n;code = 110
char = ;code = 32
char = U;code = 85
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char = ;code = 32
char = c;code = 99
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char = l;code = 108
char = s;code = 115
char = .;code = 46
result sql = Intracellular Ca2+ potentiates Na+/H+ exchange and cell differentiation induced by phorbol ester in U937 cells.
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char = e;code = 101
char = ;code = 32
char = h;code = 104
char = u;code = 117
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = c;code = 99
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char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
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char = U;code = 85
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char = 7;code = 55
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char = a;code = 97
char = t;code = 116
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char = ;code = 32
char = m;code = 109
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char = n;code = 110
char = o;code = 111
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char = e;code = 101
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char = i;code = 105
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char = ;code = 32
char = t;code = 116
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char = h;code = 104
char = o;code = 111
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char = b;code = 98
char = o;code = 111
char = l;code = 108
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char = s;code = 115
char = t;code = 116
char = e;code = 101
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char = .;code = 46
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char = T;code = 84
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
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char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = t;code = 116
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = b;code = 98
char = u;code = 117
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
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char = k;code = 107
char = i;code = 105
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char = C;code = 67
char = .;code = 46
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char = W;code = 87
char = e;code = 101
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char = h;code = 104
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char = e;code = 101
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char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = U;code = 85
char = 9;code = 57
char = 3;code = 51
char = 7;code = 55
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char = c;code = 99
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char = l;code = 108
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char = a;code = 97
char = t;code = 116
char = i;code = 105
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char = n;code = 110
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char = u;code = 117
char = c;code = 99
char = e;code = 101
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char = O;code = 79
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char = a;code = 97
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char = e;code = 101
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char = (;code = 40
char = T;code = 84
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char = A;code = 65
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char = s;code = 115
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char = m;code = 109
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char = k;code = 107
char = a;code = 97
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char = i;code = 105
char = n;code = 110
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char = z;code = 122
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = .;code = 46
char = ;code = 32
char = E;code = 69
char = t;code = 116
char = h;code = 104
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char = o;code = 111
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char = y;code = 121
char = l;code = 108
char = -;code = 45
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = l;code = 108
char = o;code = 111
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char = d;code = 100
char = e;code = 101
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char = (;code = 40
char = E;code = 69
char = I;code = 73
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char = A;code = 65
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char = i;code = 105
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char = i;code = 105
char = b;code = 98
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char = t;code = 116
char = o;code = 111
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char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = N;code = 78
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char = /;code = 47
char = H;code = 72
char = +;code = 43
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char = c;code = 99
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char = n;code = 110
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char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = b;code = 98
char = l;code = 108
char = o;code = 111
char = c;code = 99
char = k;code = 107
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = c;code = 99
char = y;code = 121
char = t;code = 116
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char = a;code = 97
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char = f;code = 102
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char = i;code = 105
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char = l;code = 108
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char = e;code = 101
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char = N;code = 78
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char = s;code = 115
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char = f;code = 102
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char = +;code = 43
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char = l;code = 108
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char = l;code = 108
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char = e;code = 101
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char = t;code = 116
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char = o;code = 111
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = s;code = 115
char = o;code = 111
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = U;code = 85
char = 9;code = 57
char = 3;code = 51
char = 7;code = 55
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = T;code = 84
char = P;code = 80
char = A;code = 65
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = y;code = 121
char = n;code = 110
char = e;code = 101
char = r;code = 114
char = g;code = 103
char = i;code = 105
char = s;code = 115
char = m;code = 109
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = g;code = 103
char = g;code = 103
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = [;code = 91
char = C;code = 67
char = a;code = 97
char = 2;code = 50
char = +;code = 43
char = ];code = 93
char = i;code = 105
char = ;code = 32
char = e;code = 101
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = s;code = 115
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char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = c;code = 99
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char = v;code = 118
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = i;code = 105
char = n;code = 110
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char = k;code = 107
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = C;code = 67
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = i;code = 105
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char = g;code = 103
char = e;code = 101
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char = d;code = 100
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char = l;code = 108
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char = s;code = 115
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char = u;code = 117
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char = s;code = 115
char = m;code = 109
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char = o;code = 111
char = u;code = 117
char = g;code = 103
char = h;code = 104
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char = e;code = 101
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char = l;code = 108
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char = e;code = 101
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char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = m;code = 109
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = m;code = 109
char = u;code = 117
char = c;code = 99
char = h;code = 104
char = ;code = 32
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
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char = r;code = 114
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char = >;code = 62
result sql = The human cell line U937 differentiates to monocyte macrophage-like cells in response to tumour-promoting phorbol esters. This effect is attributed to activation of protein kinase C. We show here that U937 cell differentiation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) is associated with cytoplasmic alkalinization. Ethyl-isopropyl-amiloride (EIPA), a potent inhibitor of Na+/H+ exchange, blocked both cytoplasmic alkalinization and cell differentiation. Cell acidification by addition of 2-4 mM sodium propionate also blocked TPA-induced U937 cell differentiation. These results suggest that a sustained cell alkalinization mediated by activation of Na+/H+ exchange is essential for TPA-induced differentiation in U937 cells. The increase of cytoplasmic free calcium concentration ([Ca2+]i) by addition of the calcium ionophore ionomycin enhanced TPA-induced alkalinization by increasing the apparent affinity of the Na+/H+ antiporter for intracellular H+. Treatment with ionomycin also potentiated differentiation of U937 cells induced by TPA. This synergism suggests that [Ca2+]i either potentiates the activation of protein kinase C or triggers additional transducing mechanisms. The key events of this interaction occur during the first 30 min of treatment, even though cell differentiation manifests much later.
char = n;code = 110
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char = a;code = 97
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = C;code = 67
char = a;code = 97
char = 2;code = 50
char = +;code = 43
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = N;code = 78
char = a;code = 97
char = +;code = 43
char = /;code = 47
char = H;code = 72
char = +;code = 43
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = g;code = 103
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = r;code = 114
char = b;code = 98
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = U;code = 85
char = 9;code = 57
char = 3;code = 51
char = 7;code = 55
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = s;code = 115
char = .;code = 46
result sql = Intracellular Ca2+ potentiates Na+/H+ exchange and cell differentiation induced by phorbol ester in U937 cells.
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char = e;code = 101
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char = h;code = 104
char = u;code = 117
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char = c;code = 99
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char = e;code = 101
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char = l;code = 108
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char = a;code = 97
char = s;code = 115
char = s;code = 115
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char = k;code = 107
char = a;code = 97
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char = E;code = 69
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char = i;code = 105
char = l;code = 108
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char = a;code = 97
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char = i;code = 105
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char = r;code = 114
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char = o;code = 111
char = f;code = 102
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char = N;code = 78
char = a;code = 97
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char = H;code = 72
char = +;code = 43
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char = l;code = 108
char = a;code = 97
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char = i;code = 105
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char = a;code = 97
char = l;code = 108
char = k;code = 107
char = a;code = 97
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char = i;code = 105
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char = z;code = 122
char = a;code = 97
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char = l;code = 108
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char = d;code = 100
char = i;code = 105
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = r;code = 114
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char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = ;code = 32
char = C;code = 67
char = e;code = 101
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char = l;code = 108
char = ;code = 32
char = a;code = 97
char = c;code = 99
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char = d;code = 100
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char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
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char = b;code = 98
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char = a;code = 97
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char = d;code = 100
char = i;code = 105
char = t;code = 116
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char = o;code = 111
char = n;code = 110
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 2;code = 50
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char = M;code = 77
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char = a;code = 97
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char = a;code = 97
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char = s;code = 115
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char = b;code = 98
char = l;code = 108
char = o;code = 111
char = c;code = 99
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char = d;code = 100
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char = T;code = 84
char = P;code = 80
char = A;code = 65
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char = u;code = 117
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char = e;code = 101
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char = c;code = 99
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char = l;code = 108
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char = f;code = 102
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char = a;code = 97
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char = i;code = 105
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char = T;code = 84
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char = e;code = 101
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char = e;code = 101
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char = t;code = 116
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char = g;code = 103
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char = s;code = 115
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char = t;code = 116
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char = a;code = 97
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char = s;code = 115
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char = a;code = 97
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char = +;code = 43
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char = T;code = 84
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char = U;code = 85
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char = c;code = 99
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char = l;code = 108
char = s;code = 115
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char = a;code = 97
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char = a;code = 97
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char = P;code = 80
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char = N;code = 78
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char = +;code = 43
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char = P;code = 80
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char = a;code = 97
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char = d;code = 100
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result sql = The human cell line U937 differentiates to monocyte macrophage-like cells in response to tumour-promoting phorbol esters. This effect is attributed to activation of protein kinase C. We show here that U937 cell differentiation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) is associated with cytoplasmic alkalinization. Ethyl-isopropyl-amiloride (EIPA), a potent inhibitor of Na+/H+ exchange, blocked both cytoplasmic alkalinization and cell differentiation. Cell acidification by addition of 2-4 mM sodium propionate also blocked TPA-induced U937 cell differentiation. These results suggest that a sustained cell alkalinization mediated by activation of Na+/H+ exchange is essential for TPA-induced differentiation in U937 cells. The increase of cytoplasmic free calcium concentration ([Ca2+]i) by addition of the calcium ionophore ionomycin enhanced TPA-induced alkalinization by increasing the apparent affinity of the Na+/H+ antiporter for intracellular H+. Treatment with ionomycin also potentiated differentiation of U937 cells induced by TPA. This synergism suggests that [Ca2+]i either potentiates the activation of protein kinase C or triggers additional transducing mechanisms. The key events of this interaction occur during the first 30 min of treatment, even though cell differentiation manifests much later.
Publication: Eur. J. Biochem. 1989 Aug 15 ;183(3)::709-14.
Publication Date: 1989 Aug 15
Study Author(s): Alvarez, J;García-Sancho, J;Mollinedo, F;Sanchez, A;
Institution: Departamento de Bioquímica y Biologia Molecular y Fisiologia, Universidad de Valladolid, Madrid, Spain.
Shortcut link to this study:
Publication Date: 1989 Aug 15
Study Author(s): Alvarez, J;García-Sancho, J;Mollinedo, F;Sanchez, A;
Institution: Departamento de Bioquímica y Biologia Molecular y Fisiologia, Universidad de Valladolid, Madrid, Spain.
Shortcut link to this study:
The human cell line U937 differentiates to monocyte macrophage-like cells in response to tumour-promoting phorbol esters. This effect is attributed to activation of protein kinase C. We show here that U937 cell differentiation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA) is associated with cytoplasmic alkalinization. Ethyl-isopropyl-amiloride (EIPA), a potent inhibitor of Na+/H+ exchange, blocked both cytoplasmic alkalinization and cell differentiation. Cell acidification by addition of 2-4 mM sodium propionate also blocked TPA-induced U937 cell differentiation. These results suggest that a sustained cell alkalinization mediated by activation of Na+/H+ exchange is essential for TPA-induced differentiation in U937 cells. The increase of cytoplasmic free calcium concentration ([Ca2+]i) by addition of the calcium ionophore ionomycin enhanced TPA-induced alkalinization by increasing the apparent affinity of the Na+/H+ antiporter for intracellular H+. Treatment with ionomycin also potentiated differentiation of U937 cells induced by TPA. This synergism suggests that [Ca2+]i either potentiates the activation of protein kinase C or triggers additional transducing mechanisms. The key events of this interaction occur during the first 30 min of treatment, even though cell differentiation manifests much later.
PMID: 2550223
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