|
|
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result sql = Potential approaches for therapeutic intervention of thrombosis by fibrinolytic agents.
Potential approaches for therapeutic intervention of thrombosis by fibrinolytic agents.char = F;code = 70
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char = T;code = 84
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char = o;code = 111
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char = t;code = 116
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char = c;code = 99
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char = f;code = 102
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char = c;code = 99
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char = h;code = 104
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char = s;code = 115
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char = i;code = 105
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char = i;code = 105
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char = n;code = 110
char = m;code = 109
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char = n;code = 110
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char = ;code = 32
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char = n;code = 110
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char = a;code = 97
char = l;code = 108
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char = m;code = 109
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char = d;code = 100
char = e;code = 101
char = l;code = 108
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = r;code = 114
char = o;code = 111
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char = o;code = 111
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char = s;code = 115
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char = e;code = 101
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = f;code = 102
char = i;code = 105
char = b;code = 98
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = t;code = 116
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
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char = P;code = 80
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char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = s;code = 115
char = c;code = 99
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char = P;code = 80
char = A;code = 65
char = -;code = 45
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = b;code = 98
char = o;code = 111
char = l;code = 108
char = y;code = 121
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = b;code = 98
char = a;code = 97
char = s;code = 115
char = e;code = 101
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char = ;code = 32
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char = ;code = 32
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char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = n;code = 110
char = t;code = 116
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char = m;code = 109
char = o;code = 111
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char = e;code = 101
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = m;code = 109
char = s;code = 115
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char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = i;code = 105
char = b;code = 98
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = -;code = 45
char = P;code = 80
char = A;code = 65
char = ;code = 32
char = o;code = 111
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char = t;code = 116
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char = n;code = 110
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char = d;code = 100
char = ;code = 32
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char = b;code = 98
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char = a;code = 97
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = D;code = 68
char = N;code = 78
char = A;code = 65
char = ;code = 32
char = t;code = 116
char = e;code = 101
char = c;code = 99
char = h;code = 104
char = n;code = 110
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char = l;code = 108
char = o;code = 111
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char = c;code = 99
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char = r;code = 114
char = e;code = 101
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char = e;code = 101
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char = t;code = 116
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char = b;code = 98
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char = s;code = 115
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char = e;code = 101
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char = e;code = 101
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char = e;code = 101
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char = o;code = 111
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char = P;code = 80
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char = ;code = 32
char = c;code = 99
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char = i;code = 105
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char = i;code = 105
char = c;code = 99
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char = e;code = 101
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char = i;code = 105
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result sql = Fibrin-specific thrombolytic agents are being developed based on a better understanding of the molecular mechanisms that regulate in vivo fibrinolysis. These agents may be more effective than those available currently and may induce less systemic fibrinolysis. In this respect, t-PA has been extensively investigated. Another fibrinolytic substance with anticipated fibrin-selectivity is scu-PA. Although scu-PA has been much less extensively investigated than t-PA, sufficient knowledge is available to evaluate its potential as a fibrin-specific thrombolytic agent. Both t-PA and scu-PA are single-chain glycoproteins with a catalytic mechanism common to all serine proteases (active site composed of the charge relay system). Both molecules occur as single-chain forms but are converted easily to two-chain disulfide bonded molecules by digestion with plasmin. Unlike most other serine proteases for which the single-chain molecular form is a zymogen with little or no activity toward its natural substrate, both single-chain t-PA and scu-PA have inherent plasminogen-activating potential. Both t-PA and scu-PA induce fibrin-specific thrombolysis in a plasma environment and in animal models of thrombosis. However, the fibrin specificity of t-PA- and scu-PA-induced thrombolysis is based on different molecular mechanisms. The effectiveness and fibrin specificity of t-PA obtained by recombinant DNA technology recently were established by three randomized multicenter trials in patients with acute myocardial infarction. For scu-PA, clinical results are presently more limited.
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char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = p;code = 112
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = a;code = 97
char = c;code = 99
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = p;code = 112
char = e;code = 101
char = u;code = 117
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = v;code = 118
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = r;code = 114
char = o;code = 111
char = m;code = 109
char = b;code = 98
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = s;code = 115
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char = b;code = 98
char = y;code = 121
char = ;code = 32
char = f;code = 102
char = i;code = 105
char = b;code = 98
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = l;code = 108
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char = i;code = 105
char = c;code = 99
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char = a;code = 97
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = .;code = 46
result sql = Potential approaches for therapeutic intervention of thrombosis by fibrinolytic agents.
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char = c;code = 99
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char = t;code = 116
char = h;code = 104
char = r;code = 114
char = o;code = 111
char = m;code = 109
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char = r;code = 114
char = e;code = 101
char = ;code = 32
char = b;code = 98
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char = i;code = 105
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char = e;code = 101
char = l;code = 108
char = o;code = 111
char = p;code = 112
char = e;code = 101
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char = a;code = 97
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char = d;code = 100
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char = o;code = 111
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char = a;code = 97
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = t;code = 116
char = t;code = 116
char = e;code = 101
char = r;code = 114
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char = u;code = 117
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = i;code = 105
char = n;code = 110
char = g;code = 103
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = m;code = 109
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
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char = m;code = 109
char = e;code = 101
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = m;code = 109
char = s;code = 115
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char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = g;code = 103
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = v;code = 118
char = o;code = 111
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char = f;code = 102
char = i;code = 105
char = b;code = 98
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = l;code = 108
char = y;code = 121
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
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char = e;code = 101
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char = a;code = 97
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char = e;code = 101
char = n;code = 110
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char = s;code = 115
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char = a;code = 97
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char = b;code = 98
char = e;code = 101
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char = m;code = 109
char = o;code = 111
char = r;code = 114
char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
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char = t;code = 116
char = h;code = 104
char = a;code = 97
char = n;code = 110
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char = t;code = 116
char = h;code = 104
char = o;code = 111
char = s;code = 115
char = e;code = 101
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char = a;code = 97
char = v;code = 118
char = a;code = 97
char = i;code = 105
char = l;code = 108
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = u;code = 117
char = r;code = 114
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = l;code = 108
char = y;code = 121
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = m;code = 109
char = a;code = 97
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char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
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char = l;code = 108
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = y;code = 121
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = f;code = 102
char = i;code = 105
char = b;code = 98
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = l;code = 108
char = y;code = 121
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = -;code = 45
char = P;code = 80
char = A;code = 65
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = t;code = 116
char = e;code = 101
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char = s;code = 115
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = v;code = 118
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = g;code = 103
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = .;code = 46
char = ;code = 32
char = A;code = 65
char = n;code = 110
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = f;code = 102
char = i;code = 105
char = b;code = 98
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = l;code = 108
char = y;code = 121
char = t;code = 116
char = i;code = 105
char = c;code = 99
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char = s;code = 115
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char = b;code = 98
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = a;code = 97
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char = t;code = 116
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = p;code = 112
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = f;code = 102
char = i;code = 105
char = b;code = 98
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = -;code = 45
char = s;code = 115
char = e;code = 101
char = l;code = 108
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = y;code = 121
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char = i;code = 105
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = c;code = 99
char = u;code = 117
char = -;code = 45
char = P;code = 80
char = A;code = 65
char = .;code = 46
char = ;code = 32
char = A;code = 65
char = l;code = 108
char = t;code = 116
char = h;code = 104
char = o;code = 111
char = u;code = 117
char = g;code = 103
char = h;code = 104
char = ;code = 32
char = s;code = 115
char = c;code = 99
char = u;code = 117
char = -;code = 45
char = P;code = 80
char = A;code = 65
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = s;code = 115
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char = b;code = 98
char = e;code = 101
char = e;code = 101
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char = m;code = 109
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char = c;code = 99
char = h;code = 104
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char = s;code = 115
char = s;code = 115
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char = e;code = 101
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char = t;code = 116
char = e;code = 101
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char = s;code = 115
char = i;code = 105
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char = e;code = 101
char = l;code = 108
char = y;code = 121
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char = n;code = 110
char = v;code = 118
char = e;code = 101
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char = t;code = 116
char = i;code = 105
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char = a;code = 97
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char = e;code = 101
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char = h;code = 104
char = a;code = 97
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char = t;code = 116
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char = P;code = 80
char = A;code = 65
char = ,;code = 44
char = ;code = 32
char = s;code = 115
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char = f;code = 102
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char = c;code = 99
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char = k;code = 107
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char = o;code = 111
char = w;code = 119
char = l;code = 108
char = e;code = 101
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char = g;code = 103
char = e;code = 101
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char = s;code = 115
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char = a;code = 97
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char = a;code = 97
char = b;code = 98
char = l;code = 108
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char = o;code = 111
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char = a;code = 97
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char = u;code = 117
char = a;code = 97
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char = i;code = 105
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char = s;code = 115
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char = o;code = 111
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char = a;code = 97
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char = a;code = 97
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char = ;code = 32
char = a;code = 97
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char = f;code = 102
char = i;code = 105
char = b;code = 98
char = r;code = 114
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char = n;code = 110
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char = p;code = 112
char = e;code = 101
char = c;code = 99
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char = f;code = 102
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char = c;code = 99
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char = t;code = 116
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char = r;code = 114
char = o;code = 111
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char = c;code = 99
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char = e;code = 101
char = n;code = 110
char = t;code = 116
char = .;code = 46
char = ;code = 32
char = B;code = 66
char = o;code = 111
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = t;code = 116
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char = P;code = 80
char = A;code = 65
char = ;code = 32
char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = s;code = 115
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char = P;code = 80
char = A;code = 65
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = i;code = 105
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char = a;code = 97
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char = l;code = 108
char = y;code = 121
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char = p;code = 112
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char = t;code = 116
char = e;code = 101
char = i;code = 105
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char = s;code = 115
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
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char = a;code = 97
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char = c;code = 99
char = a;code = 97
char = t;code = 116
char = a;code = 97
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char = y;code = 121
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char = i;code = 105
char = c;code = 99
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char = e;code = 101
char = c;code = 99
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char = a;code = 97
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = m;code = 109
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char = c;code = 99
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char = m;code = 109
char = m;code = 109
char = o;code = 111
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char = a;code = 97
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char = l;code = 108
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char = e;code = 101
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char = r;code = 114
char = o;code = 111
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char = a;code = 97
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char = (;code = 40
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char = t;code = 116
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char = v;code = 118
char = e;code = 101
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char = t;code = 116
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char = p;code = 112
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char = d;code = 100
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char = g;code = 103
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char = s;code = 115
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char = i;code = 105
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char = t;code = 116
char = w;code = 119
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char = e;code = 101
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char = u;code = 117
char = l;code = 108
char = e;code = 101
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char = t;code = 116
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char = p;code = 112
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char = a;code = 97
char = s;code = 115
char = m;code = 109
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char = .;code = 46
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char = U;code = 85
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char = l;code = 108
char = i;code = 105
char = k;code = 107
char = e;code = 101
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char = m;code = 109
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char = s;code = 115
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char = o;code = 111
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char = h;code = 104
char = e;code = 101
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char = o;code = 111
char = t;code = 116
char = e;code = 101
char = a;code = 97
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char = e;code = 101
char = s;code = 115
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char = f;code = 102
char = o;code = 111
char = r;code = 114
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char = w;code = 119
char = h;code = 104
char = i;code = 105
char = c;code = 99
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char = h;code = 104
char = e;code = 101
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char = i;code = 105
char = n;code = 110
char = g;code = 103
char = l;code = 108
char = e;code = 101
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char = c;code = 99
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char = a;code = 97
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char = n;code = 110
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char = m;code = 109
char = o;code = 111
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char = e;code = 101
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char = u;code = 117
char = l;code = 108
char = a;code = 97
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char = f;code = 102
char = o;code = 111
char = r;code = 114
char = m;code = 109
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char = i;code = 105
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char = a;code = 97
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char = z;code = 122
char = y;code = 121
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char = o;code = 111
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char = e;code = 101
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char = w;code = 119
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = t;code = 116
char = t;code = 116
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result sql = Fibrin-specific thrombolytic agents are being developed based on a better understanding of the molecular mechanisms that regulate in vivo fibrinolysis. These agents may be more effective than those available currently and may induce less systemic fibrinolysis. In this respect, t-PA has been extensively investigated. Another fibrinolytic substance with anticipated fibrin-selectivity is scu-PA. Although scu-PA has been much less extensively investigated than t-PA, sufficient knowledge is available to evaluate its potential as a fibrin-specific thrombolytic agent. Both t-PA and scu-PA are single-chain glycoproteins with a catalytic mechanism common to all serine proteases (active site composed of the charge relay system). Both molecules occur as single-chain forms but are converted easily to two-chain disulfide bonded molecules by digestion with plasmin. Unlike most other serine proteases for which the single-chain molecular form is a zymogen with little or no activity toward its natural substrate, both single-chain t-PA and scu-PA have inherent plasminogen-activating potential. Both t-PA and scu-PA induce fibrin-specific thrombolysis in a plasma environment and in animal models of thrombosis. However, the fibrin specificity of t-PA- and scu-PA-induced thrombolysis is based on different molecular mechanisms. The effectiveness and fibrin specificity of t-PA obtained by recombinant DNA technology recently were established by three randomized multicenter trials in patients with acute myocardial infarction. For scu-PA, clinical results are presently more limited.
Publication: Semin. Thromb. Hemost. 1988 Jan ;14(1)::95-9.
Publication Date: 1988 Jan
Study Author(s): Collen, D;
Institution: Center for Thrombosis and Vascular Research, University of Leuven, Belgium.
Shortcut link to this study:
Publication Date: 1988 Jan
Study Author(s): Collen, D;
Institution: Center for Thrombosis and Vascular Research, University of Leuven, Belgium.
Shortcut link to this study:
Fibrin-specific thrombolytic agents are being developed based on a better understanding of the molecular mechanisms that regulate in vivo fibrinolysis. These agents may be more effective than those available currently and may induce less systemic fibrinolysis. In this respect, t-PA has been extensively investigated. Another fibrinolytic substance with anticipated fibrin-selectivity is scu-PA. Although scu-PA has been much less extensively investigated than t-PA, sufficient knowledge is available to evaluate its potential as a fibrin-specific thrombolytic agent. Both t-PA and scu-PA are single-chain glycoproteins with a catalytic mechanism common to all serine proteases (active site composed of the charge relay system). Both molecules occur as single-chain forms but are converted easily to two-chain disulfide bonded molecules by digestion with plasmin. Unlike most other serine proteases for which the single-chain molecular form is a zymogen with little or no activity toward its natural substrate, both single-chain t-PA and scu-PA have inherent plasminogen-activating potential. Both t-PA and scu-PA induce fibrin-specific thrombolysis in a plasma environment and in animal models of thrombosis. However, the fibrin specificity of t-PA- and scu-PA-induced thrombolysis is based on different molecular mechanisms. The effectiveness and fibrin specificity of t-PA obtained by recombinant DNA technology recently were established by three randomized multicenter trials in patients with acute myocardial infarction. For scu-PA, clinical results are presently more limited.
PMID: 3127886
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