char = I;code = 73 char = n;code = 110 char = f;code = 102 char = l;code = 108 char = u;code = 117 char = e;code = 101 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = l;code = 108 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = i;code = 105 char = u;code = 117 char = m;code = 109 char = ;code = 32 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = i;code = 105 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = v;code = 118 char = u;code = 117 char = l;code = 108 char = s;code = 115 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = v;code = 118 char = i;code = 105 char = t;code = 116 char = y;code = 121 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = c;code = 99 char = a;code = 97 char = r;code = 114 char = b;code = 98 char = a;code = 97 char = m;code = 109 char = a;code = 97 char = z;code = 122 char = e;code = 101 char = p;code = 112 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = .;code = 46 result sql = Influence of lithium on the anticonvulsant activity of carbamazepine.
Influence of lithium on the anticonvulsant activity of carbamazepine.char = T;code = 84 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = s;code = 115 char = t;code = 116 char = u;code = 117 char = d;code = 100 char = y;code = 121 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = u;code = 117 char = n;code = 110 char = d;code = 100 char = e;code = 101 char = r;code = 114 char = t;code = 116 char = a;code = 97 char = k;code = 107 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = e;code = 101 char = ;code = 32 char = w;code = 119 char = h;code = 104 char = e;code = 101 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = c;code = 99 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = l;code = 108 char = y;code = 121 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = p;code = 112 char = o;code = 111 char = r;code = 114 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = s;code = 115 char = y;code = 121 char = n;code = 110 char = e;code = 101 char = r;code = 114 char = g;code = 103 char = i;code = 105 char = s;code = 115 char = m;code = 109 char = ;code = 32 char = b;code = 98 char = e;code = 101 char = t;code = 116 char = w;code = 119 char = e;code = 101 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = l;code = 108 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = i;code = 105 char = u;code = 117 char = m;code = 109 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = c;code = 99 char = a;code = 97 char = r;code = 114 char = b;code = 98 char = a;code = 97 char = m;code = 109 char = a;code = 97 char = z;code = 122 char = e;code = 101 char = p;code = 112 char = i;code = 105 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = (;code = 40 char = C;code = 67 char = B;code = 66 char = Z;code = 90 char = );code = 41 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = m;code = 109 char = a;code = 97 char = n;code = 110 char = i;code = 105 char = a;code = 97 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = s;code = 115 char = o;code = 111 char = ;code = 32 char = e;code = 101 char = x;code = 120 char = t;code = 116 char = e;code = 101 char = n;code = 110 char = d;code = 100 char = s;code = 115 char = ;code = 32 char = a;code = 97 char = g;code = 103 char = a;code = 97 char = i;code = 105 char = n;code = 110 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = v;code = 118 char = u;code = 117 char = l;code = 108 char = s;code = 115 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = .;code = 46 char = ;code = 32 char = T;code = 84 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = i;code = 105 char = -;code = 45 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = v;code = 118 char = u;code = 117 char = l;code = 108 char = s;code = 115 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = e;code = 101 char = f;code = 102 char = f;code = 102 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = v;code = 118 char = a;code = 97 char = r;code = 114 char = i;code = 105 char = o;code = 111 char = u;code = 117 char = s;code = 115 char = ;code = 32 char = d;code = 100 char = o;code = 111 char = s;code = 115 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = C;code = 67 char = B;code = 66 char = Z;code = 90 char = ;code = 32 char = w;code = 119 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = a;code = 97 char = s;code = 115 char = s;code = 115 char = e;code = 101 char = s;code = 115 char = s;code = 115 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = b;code = 98 char = i;code = 105 char = n;code = 110 char = o;code = 111 char = ;code = 32 char = r;code = 114 char = a;code = 97 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = p;code = 112 char = r;code = 114 char = e;code = 101 char = t;code = 116 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = w;code = 119 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = ;code = 32 char = v;code = 118 char = e;code = 101 char = h;code = 104 char = i;code = 105 char = c;code = 99 char = l;code = 108 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = l;code = 108 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = i;code = 105 char = u;code = 117 char = m;code = 109 char = ;code = 32 char = s;code = 115 char = a;code = 97 char = l;code = 108 char = t;code = 116 char = ;code = 32 char = (;code = 40 char = 0;code = 48 char = .;code = 46 char = 5;code = 53 char = 4;code = 52 char = ;code = 32 char = m;code = 109 char = E;code = 69 char = g;code = 103 char = /;code = 47 char = k;code = 107 char = g;code = 103 char = /;code = 47 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = ,;code = 44 char = ;code = 32 char = p;code = 112 char = .;code = 46 char = o;code = 111 char = .;code = 46 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = 9;code = 57 char = ;code = 32 char = d;code = 100 char = a;code = 97 char = y;code = 121 char = s;code = 115 char = );code = 41 char = .;code = 46 char = ;code = 32 char = T;code = 84 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = i;code = 105 char = m;code = 109 char = a;code = 97 char = l;code = 108 char = s;code = 115 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = s;code = 115 char = u;code = 117 char = b;code = 98 char = j;code = 106 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = o;code = 111 char = ;code = 32 char = 3;code = 51 char = ;code = 32 char = t;code = 116 char = e;code = 101 char = s;code = 115 char = t;code = 116 char = s;code = 115 char = :;code = 58 char = ;code = 32 char = m;code = 109 char = a;code = 97 char = x;code = 120 char = i;code = 105 char = m;code = 109 char = u;code = 117 char = m;code = 109 char = ;code = 32 char = e;code = 101 char = l;code = 108 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = ;code = 32 char = s;code = 115 char = h;code = 104 char = o;code = 111 char = c;code = 99 char = k;code = 107 char = ;code = 32 char = s;code = 115 char = e;code = 101 char = i;code = 105 char = z;code = 122 char = u;code = 117 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = M;code = 77 char = E;code = 69 char = S;code = 83 char = );code = 41 char = ;;code = 59 char = ;code = 32 char = m;code = 109 char = i;code = 105 char = n;code = 110 char = i;code = 105 char = m;code = 109 char = u;code = 117 char = m;code = 109 char = ;code = 32 char = e;code = 101 char = l;code = 108 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = v;code = 118 char = u;code = 117 char = l;code = 108 char = s;code = 115 char = i;code = 105 char = v;code = 118 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = h;code = 104 char = o;code = 111 char = l;code = 108 char = d;code = 100 char = s;code = 115 char = ;code = 32 char = (;code = 40 char = M;code = 77 char = E;code = 69 char = T;code = 84 char = );code = 41 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = p;code = 112 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = y;code = 121 char = l;code = 108 char = e;code = 101 char = n;code = 110 char = e;code = 101 char = t;code = 116 char = e;code = 101 char = t;code = 116 char = r;code = 114 char = a;code = 97 char = z;code = 122 char = o;code = 111 char = l;code = 108 char = ;code = 32 char = (;code = 40 char = P;code = 80 char = T;code = 84 char = Z;code = 90 char = );code = 41 char = -;code = 45 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = v;code = 118 char = u;code = 117 char = l;code = 108 char = s;code = 115 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = :;code = 58 char = ;code = 32 char = a;code = 97 char = b;code = 98 char = o;code = 111 char = l;code = 108 char = i;code = 105 char = t;code = 116 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = h;code = 104 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = l;code = 108 char = i;code = 105 char = m;code = 109 char = b;code = 98 char = ;code = 32 char = e;code = 101 char = x;code = 120 char = t;code = 116 char = e;code = 101 char = n;code = 110 char = s;code = 115 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = f;code = 102 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = e;code = 101 char = l;code = 108 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = r;code = 114 char = o;code = 111 char = ;code = 32 char = s;code = 115 char = h;code = 104 char = o;code = 111 char = c;code = 99 char = k;code = 107 char = ,;code = 44 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = c;code = 99 char = r;code = 114 char = e;code = 101 char = a;code = 97 char = s;code = 115 char = e;code = 101 char = s;code = 115 char = ;code = 32 char = i;code = 105 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = M;code = 77 char = E;code = 69 char = T;code = 84 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = a;code = 97 char = p;code = 112 char = p;code = 112 char = e;code = 101 char = a;code = 97 char = r;code = 114 char = a;code = 97 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = n;code = 110 char = e;code = 101 char = c;code = 99 char = k;code = 107 char = ;code = 32 char = j;code = 106 char = e;code = 101 char = r;code = 114 char = k;code = 107 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = a;code = 97 char = b;code = 98 char = s;code = 115 char = e;code = 101 char = n;code = 110 char = c;code = 99 char = e;code = 101 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = v;code = 118 char = u;code = 117 char = l;code = 108 char = s;code = 115 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = ;code = 32 char = f;code = 102 char = o;code = 111 char = r;code = 114 char = ;code = 32 char = o;code = 111 char = n;code = 110 char = e;code = 101 char = ;code = 32 char = h;code = 104 char = r;code = 114 char = ;code = 32 char = a;code = 97 char = f;code = 102 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = P;code = 80 char = T;code = 84 char = Z;code = 90 char = ;code = 32 char = w;code = 119 char = e;code = 101 char = r;code = 114 char = e;code = 101 char = ;code = 32 char = t;code = 116 char = a;code = 97 char = k;code = 107 char = e;code = 101 char = n;code = 110 char = ;code = 32 char = a;code = 97 char = s;code = 115 char = ;code = 32 char = p;code = 112 char = a;code = 97 char = r;code = 114 char = a;code = 97 char = m;code = 109 char = e;code = 101 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = s;code = 115 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = i;code = 105 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = v;code = 118 char = u;code = 117 char = l;code = 108 char = s;code = 115 char = i;code = 105 char = v;code = 118 char = e;code = 101 char = ;code = 32 char = e;code = 101 char = f;code = 102 char = f;code = 102 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = ;code = 32 char = r;code = 114 char = e;code = 101 char = s;code = 115 char = p;code = 112 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = i;code = 105 char = v;code = 118 char = e;code = 101 char = l;code = 108 char = y;code = 121 char = .;code = 46 char = ;code = 32 char = I;code = 73 char = n;code = 110 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = M;code = 77 char = E;code = 69 char = S;code = 83 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = d;code = 100 char = ;code = 32 char = M;code = 77 char = E;code = 69 char = T;code = 84 char = ;code = 32 char = t;code = 116 char = e;code = 101 char = s;code = 115 char = t;code = 116 char = s;code = 115 char = ;code = 32 char = l;code = 108 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = u;code = 117 char = m;code = 109 char = ;code = 32 char = d;code = 100 char = i;code = 105 char = d;code = 100 char = ;code = 32 char = n;code = 110 char = o;code = 111 char = t;code = 116 char = ;code = 32 char = a;code = 97 char = l;code = 108 char = t;code = 116 char = e;code = 101 char = r;code = 114 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = i;code = 105 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = v;code = 118 char = u;code = 117 char = l;code = 108 char = s;code = 115 char = i;code = 105 char = v;code = 118 char = e;code = 101 char = ;code = 32 char = e;code = 101 char = f;code = 102 char = f;code = 102 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = C;code = 67 char = B;code = 66 char = Z;code = 90 char = .;code = 46 char = ;code = 32 char = L;code = 76 char = i;code = 105 char = t;code = 116 char = h;code = 104 char = i;code = 105 char = u;code = 117 char = m;code = 109 char = ,;code = 44 char = ;code = 32 char = h;code = 104 char = o;code = 111 char = w;code = 119 char = e;code = 101 char = v;code = 118 char = e;code = 101 char = r;code = 114 char = ,;code = 44 char = ;code = 32 char = p;code = 112 char = o;code = 111 char = t;code = 116 char = e;code = 101 char = n;code = 110 char = t;code = 116 char = i;code = 105 char = a;code = 97 char = t;code = 116 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = t;code = 116 char = h;code = 104 char = e;code = 101 char = ;code = 32 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = i;code = 105 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = v;code = 118 char = u;code = 117 char = l;code = 108 char = s;code = 115 char = a;code = 97 char = n;code = 110 char = t;code = 116 char = ;code = 32 char = e;code = 101 char = f;code = 102 char = f;code = 102 char = e;code = 101 char = c;code = 99 char = t;code = 116 char = ;code = 32 char = o;code = 111 char = f;code = 102 char = ;code = 32 char = C;code = 67 char = B;code = 66 char = Z;code = 90 char = ;code = 32 char = a;code = 97 char = g;code = 103 char = a;code = 97 char = i;code = 105 char = n;code = 110 char = s;code = 115 char = t;code = 116 char = ;code = 32 char = P;code = 80 char = T;code = 84 char = Z;code = 90 char = -;code = 45 char = i;code = 105 char = n;code = 110 char = d;code = 100 char = u;code = 117 char = c;code = 99 char = e;code = 101 char = d;code = 100 char = ;code = 32 char = c;code = 99 char = o;code = 111 char = n;code = 110 char = v;code = 118 char = u;code = 117 char = l;code = 108 char = s;code = 115 char = i;code = 105 char = o;code = 111 char = n;code = 110 char = s;code = 115 char = .;code = 46 char = <;code = 60 char = b;code = 98 char = r;code = 114 char = /;code = 47 char = >;code = 62 result sql = The present study was undertaken to see whether the recently reported synergism between lithium and carbamazepine (CBZ) in mania also extends against convulsions. The anti-convulsant effect of various doses of CBZ was assessed in albino rats pretreated with vehicle or lithium salt (0.54 mEg/kg/day, p.o. for 9 days). The animals were subjected to 3 tests: maximum electro shock seizures (MES); minimum electro convulsive thresholds (MET) and pentylenetetrazol (PTZ)-induced convulsions: abolition of hind limb extension after electro shock, increases in the MET for appearance of neck jerk and absence of convulsions for one hr after PTZ were taken as parameters of the anticonvulsive effect respectively. In the MES and MET tests lithum did not alter the anticonvulsive effect of CBZ. Lithium, however, potentiated the anticonvulsant effect of CBZ against PTZ-induced convulsions.
Publication: Indian J. Physiol. Pharmacol. 1987 Jan-Mar ;31(1)::35-41.
Publication Date: 1987 Jan-Mar
Study Author(s): Kadlimatti, S H;Joseph, T;
Institution: Department of Pharmacology, St. John's Medical College, Bangalore.
Shortcut link to this study:
The present study was undertaken to see whether the recently reported synergism between lithium and carbamazepine (CBZ) in mania also extends against convulsions. The anti-convulsant effect of various doses of CBZ was assessed in albino rats pretreated with vehicle or lithium salt (0.54 mEg/kg/day, p.o. for 9 days). The animals were subjected to 3 tests: maximum electro shock seizures (MES); minimum electro convulsive thresholds (MET) and pentylenetetrazol (PTZ)-induced convulsions: abolition of hind limb extension after electro shock, increases in the MET for appearance of neck jerk and absence of convulsions for one hr after PTZ were taken as parameters of the anticonvulsive effect respectively. In the MES and MET tests lithum did not alter the anticonvulsive effect of CBZ. Lithium, however, potentiated the anticonvulsant effect of CBZ against PTZ-induced convulsions.
PMID: 3666873