char = L;code = 76
char = V;code = 86
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = V;code = 86
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = O;code = 79
char = -;code = 45
char = E;code = 69
char = t;code = 116
char = h;code = 104
char = y;code = 121
char = l;code = 108
char = ;code = 32
char = M;code = 77
char = a;code = 97
char = l;code = 108
char = t;code = 116
char = o;code = 111
char = l;code = 108
char = -;code = 45
char = B;code = 66
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = M;code = 77
char = e;code = 101
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = o;code = 111
char = d;code = 100
char = r;code = 114
char = u;code = 117
char = g;code = 103
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = L;code = 76
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = 2;code = 50
char = -;code = 45
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = ;code = 32
char = =;code = 61
char = ;code = 32
char = T;code = 84
char = r;code = 114
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = O;code = 79
char = N;code = 78
char = O;code = 79
char = ;code = 32
char = L;code = 76
char = i;code = 105
char = g;code = 103
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = s;code = 115
char = );code = 41
char = :;code = 58
char = ;code = 32
char = H;code = 72
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = b;code = 98
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ,;code = 44
char = ;code = 32
char = H;code = 72
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = y;code = 121
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = S;code = 83
char = t;code = 116
char = a;code = 97
char = b;code = 98
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = C;code = 67
char = y;code = 121
char = t;code = 116
char = o;code = 111
char = t;code = 116
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = a;code = 97
char = ;code = 32
char = R;code = 82
char = O;code = 79
char = S;code = 83
char = -;code = 45
char = M;code = 77
char = e;code = 101
char = d;code = 100
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = A;code = 65
char = p;code = 112
char = o;code = 111
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = .;code = 46
result sql = LV^VO-Ethyl Maltol-Based Metallodrugs (L^2- = Tridentate ONO Ligands): Hydrophobicity, Hydrolytic Stability, and Cytotoxicity via ROS-Mediated Apoptosis.
LV^VO-Ethyl Maltol-Based Metallodrugs (L^2- = Tridentate ONO Ligands): Hydrophobicity, Hydrolytic Stability, and Cytotoxicity via ROS-Mediated Apoptosis.
char = F;code = 70
char = o;code = 111
char = u;code = 117
char = r;code = 114
char = ;code = 32
char = n;code = 110
char = e;code = 101
char = w;code = 119
char = ;code = 32
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = d;code = 100
char = o;code = 111
char = v;code = 118
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = d;code = 100
char = i;code = 105
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = [;code = 91
char = V;code = 86
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = V;code = 86
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = O;code = 79
char = L;code = 76
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = 1;code = 49
char = -;code = 45
char = 4;code = 52
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = (;code = 40
char = e;code = 101
char = m;code = 109
char = a;code = 97
char = );code = 41
char = ];code = 93
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = l;code = 108
char = e;code = 101
char = x;code = 120
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = 1;code = 49
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = -;code = 45
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = 4;code = 52
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = );code = 41
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = y;code = 121
char = n;code = 110
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = s;code = 115
char = i;code = 105
char = z;code = 122
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = u;code = 117
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = b;code = 98
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = g;code = 103
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = O;code = 79
char = N;code = 78
char = O;code = 79
char = ;code = 32
char = d;code = 100
char = o;code = 111
char = n;code = 110
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = g;code = 103
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = s;code = 115
char = ;code = 32
char = H;code = 72
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = >;code = 62
char = 2;code = 50
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = >;code = 62
char = L;code = 76
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = 1;code = 49
char = -;code = 45
char = 4;code = 52
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = ;code = 32
char = [;code = 91
char = H;code = 72
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = >;code = 62
char = 2;code = 50
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = >;code = 62
char = L;code = 76
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = 1;code = 49
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = :;code = 58
char = ;code = 32
char = (;code = 40
char = <;code = 60
char = i;code = 105
char = >;code = 62
char = E;code = 69
char = <;code = 60
char = /;code = 47
char = i;code = 105
char = >;code = 62
char = );code = 41
char = -;code = 45
char = <;code = 60
char = i;code = 105
char = >;code = 62
char = N;code = 78
char = ';code = 39
char = <;code = 60
char = /;code = 47
char = i;code = 105
char = >;code = 62
char = -;code = 45
char = (;code = 40
char = 2;code = 50
char = -;code = 45
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = x;code = 120
char = y;code = 121
char = b;code = 98
char = e;code = 101
char = n;code = 110
char = z;code = 122
char = y;code = 121
char = l;code = 108
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = );code = 41
char = f;code = 102
char = u;code = 117
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = -;code = 45
char = 2;code = 50
char = -;code = 45
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = b;code = 98
char = o;code = 111
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = a;code = 97
char = z;code = 122
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = ;;code = 59
char = ;code = 32
char = H;code = 72
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = >;code = 62
char = 2;code = 50
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = >;code = 62
char = L;code = 76
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = 2;code = 50
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = :;code = 58
char = ;code = 32
char = (;code = 40
char = <;code = 60
char = i;code = 105
char = >;code = 62
char = E;code = 69
char = <;code = 60
char = /;code = 47
char = i;code = 105
char = >;code = 62
char = );code = 41
char = -;code = 45
char = <;code = 60
char = i;code = 105
char = >;code = 62
char = N;code = 78
char = ';code = 39
char = <;code = 60
char = /;code = 47
char = i;code = 105
char = >;code = 62
char = -;code = 45
char = (;code = 40
char = 4;code = 52
char = -;code = 45
char = (;code = 40
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = y;code = 121
char = l;code = 108
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = );code = 41
char = -;code = 45
char = 2;code = 50
char = -;code = 45
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = x;code = 120
char = y;code = 121
char = b;code = 98
char = e;code = 101
char = n;code = 110
char = z;code = 122
char = y;code = 121
char = l;code = 108
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = );code = 41
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = o;code = 111
char = p;code = 112
char = h;code = 104
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = -;code = 45
char = 2;code = 50
char = -;code = 45
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = b;code = 98
char = o;code = 111
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = a;code = 97
char = z;code = 122
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = ;;code = 59
char = ;code = 32
char = H;code = 72
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = >;code = 62
char = 2;code = 50
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = >;code = 62
char = L;code = 76
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = 3;code = 51
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = :;code = 58
char = ;code = 32
char = (;code = 40
char = <;code = 60
char = i;code = 105
char = >;code = 62
char = E;code = 69
char = <;code = 60
char = /;code = 47
char = i;code = 105
char = >;code = 62
char = );code = 41
char = -;code = 45
char = 2;code = 50
char = -;code = 45
char = (;code = 40
char = 4;code = 52
char = -;code = 45
char = (;code = 40
char = d;code = 100
char = i;code = 105
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = y;code = 121
char = l;code = 108
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = );code = 41
char = -;code = 45
char = 2;code = 50
char = -;code = 45
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = x;code = 120
char = y;code = 121
char = b;code = 98
char = e;code = 101
char = n;code = 110
char = z;code = 122
char = y;code = 121
char = l;code = 108
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = );code = 41
char = -;code = 45
char = 4;code = 52
char = -;code = 45
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = y;code = 121
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = e;code = 101
char = n;code = 110
char = o;code = 111
char = l;code = 108
char = ;;code = 59
char = ;code = 32
char = H;code = 72
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = >;code = 62
char = 2;code = 50
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = >;code = 62
char = L;code = 76
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = 4;code = 52
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = :;code = 58
char = ;code = 32
char = (;code = 40
char = <;code = 60
char = i;code = 105
char = >;code = 62
char = E;code = 69
char = <;code = 60
char = /;code = 47
char = i;code = 105
char = >;code = 62
char = );code = 41
char = -;code = 45
char = 2;code = 50
char = -;code = 45
char = (;code = 40
char = 3;code = 51
char = -;code = 45
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = o;code = 111
char = x;code = 120
char = y;code = 121
char = -;code = 45
char = 2;code = 50
char = -;code = 45
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = x;code = 120
char = y;code = 121
char = b;code = 98
char = e;code = 101
char = n;code = 110
char = z;code = 122
char = y;code = 121
char = l;code = 108
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = a;code = 97
char = m;code = 109
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = );code = 41
char = -;code = 45
char = 4;code = 52
char = -;code = 45
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = y;code = 121
char = l;code = 108
char = p;code = 112
char = h;code = 104
char = e;code = 101
char = n;code = 110
char = o;code = 111
char = l;code = 108
char = ];code = 93
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = y;code = 121
char = l;code = 108
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = t;code = 116
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = (;code = 40
char = H;code = 72
char = e;code = 101
char = m;code = 109
char = a;code = 97
char = );code = 41
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = b;code = 98
char = i;code = 105
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = u;code = 117
char = n;code = 110
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = g;code = 103
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = l;code = 108
char = i;code = 105
char = g;code = 103
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = a;code = 97
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = z;code = 122
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = C;code = 67
char = H;code = 72
char = N;code = 78
char = S;code = 83
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = y;code = 121
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = I;code = 73
char = R;code = 82
char = ,;code = 44
char = ;code = 32
char = U;code = 85
char = V;code = 86
char = -;code = 45
char = v;code = 118
char = i;code = 105
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = N;code = 78
char = M;code = 77
char = R;code = 82
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = H;code = 72
char = R;code = 82
char = -;code = 45
char = E;code = 69
char = S;code = 83
char = I;code = 73
char = -;code = 45
char = M;code = 77
char = S;code = 83
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = o;code = 111
char = d;code = 100
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = r;code = 114
char = u;code = 117
char = c;code = 99
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = 1;code = 49
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = ,;code = 44
char = ;code = 32
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = 3;code = 51
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = 4;code = 52
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = f;code = 102
char = i;code = 105
char = r;code = 114
char = m;code = 109
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = l;code = 108
char = e;code = 101
char = -;code = 45
char = c;code = 99
char = r;code = 114
char = y;code = 121
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = X;code = 88
char = -;code = 45
char = r;code = 114
char = a;code = 97
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = y;code = 121
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = p;code = 112
char = h;code = 104
char = o;code = 111
char = b;code = 98
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = y;code = 121
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = b;code = 98
char = i;code = 105
char = l;code = 108
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = l;code = 108
char = e;code = 101
char = x;code = 120
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = u;code = 117
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = N;code = 78
char = M;code = 77
char = R;code = 82
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = H;code = 72
char = R;code = 82
char = -;code = 45
char = E;code = 69
char = S;code = 83
char = I;code = 73
char = -;code = 45
char = M;code = 77
char = S;code = 83
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = r;code = 114
char = r;code = 114
char = e;code = 101
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = i;code = 105
char = r;code = 114
char = ;code = 32
char = o;code = 111
char = b;code = 98
char = s;code = 115
char = e;code = 101
char = r;code = 114
char = v;code = 118
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = i;code = 105
char = o;code = 111
char = l;code = 108
char = o;code = 111
char = g;code = 103
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = t;code = 116
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = b;code = 98
char = s;code = 115
char = e;code = 101
char = r;code = 114
char = v;code = 118
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = 1;code = 49
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = l;code = 108
char = y;code = 121
char = z;code = 122
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = p;code = 112
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = a;code = 97
char = -;code = 45
char = c;code = 99
char = o;code = 111
char = o;code = 111
char = r;code = 114
char = d;code = 100
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = v;code = 118
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = d;code = 100
char = i;code = 105
char = u;code = 117
char = m;code = 109
char = -;code = 45
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = x;code = 120
char = y;code = 121
char = l;code = 108
char = ;code = 32
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = (;code = 40
char = V;code = 86
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = V;code = 86
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = O;code = 79
char = L;code = 76
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = 1;code = 49
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = -;code = 45
char = O;code = 79
char = H;code = 72
char = );code = 41
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = l;code = 108
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = y;code = 121
char = l;code = 108
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = t;code = 116
char = o;code = 111
char = l;code = 108
char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = 2;code = 50
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = -;code = 45
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = 4;code = 52
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = f;code = 102
char = o;code = 111
char = u;code = 117
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = q;code = 113
char = u;code = 117
char = i;code = 105
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = a;code = 97
char = b;code = 98
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = u;code = 117
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = v;code = 118
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = g;code = 103
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = i;code = 105
char = m;code = 109
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = i;code = 105
char = o;code = 111
char = d;code = 100
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = b;code = 98
char = i;code = 105
char = o;code = 111
char = m;code = 109
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = 1;code = 49
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = -;code = 45
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = 4;code = 52
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = D;code = 68
char = N;code = 78
char = A;code = 65
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = B;code = 66
char = S;code = 83
char = A;code = 65
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = u;code = 117
char = s;code = 115
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = a;code = 97
char = b;code = 98
char = s;code = 115
char = o;code = 111
char = r;code = 114
char = b;code = 98
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = f;code = 102
char = l;code = 108
char = u;code = 117
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = c;code = 99
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = i;code = 105
char = r;code = 114
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = c;code = 99
char = h;code = 104
char = r;code = 114
char = o;code = 111
char = i;code = 105
char = s;code = 115
char = m;code = 109
char = ;code = 32
char = t;code = 116
char = e;code = 101
char = c;code = 99
char = h;code = 104
char = n;code = 110
char = i;code = 105
char = q;code = 113
char = u;code = 117
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = <;code = 60
char = i;code = 105
char = >;code = 62
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = r;code = 114
char = o;code = 111
char = <;code = 60
char = /;code = 47
char = i;code = 105
char = >;code = 62
char = ;code = 32
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = o;code = 111
char = t;code = 116
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = H;code = 72
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = >;code = 62
char = 2;code = 50
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = >;code = 62
char = L;code = 76
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = 1;code = 49
char = -;code = 45
char = 4;code = 52
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = p;code = 112
char = >;code = 62
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = 1;code = 49
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = -;code = 45
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = 4;code = 52
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = A;code = 65
char = 5;code = 53
char = 4;code = 52
char = 9;code = 57
char = ,;code = 44
char = ;code = 32
char = H;code = 72
char = T;code = 84
char = -;code = 45
char = 2;code = 50
char = 9;code = 57
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = N;code = 78
char = I;code = 73
char = H;code = 72
char = -;code = 45
char = 3;code = 51
char = T;code = 84
char = 3;code = 51
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = A;code = 65
char = m;code = 109
char = o;code = 111
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = l;code = 108
char = e;code = 101
char = x;code = 120
char = e;code = 101
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = 2;code = 50
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = I;code = 73
char = C;code = 67
char = <;code = 60
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = >;code = 62
char = 5;code = 53
char = 0;code = 48
char = <;code = 60
char = /;code = 47
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = >;code = 62
char = ;code = 32
char = v;code = 118
char = a;code = 97
char = l;code = 108
char = u;code = 117
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = 4;code = 52
char = .;code = 46
char = 4;code = 52
char = ;code = 32
char = &;code = 38
char = #;code = 35
char = x;code = 120
char = b;code = 98
char = 1;code = 49
char = ;;code = 59
char = ;code = 32
char = 0;code = 48
char = .;code = 46
char = 1;code = 49
char = ;code = 32
char = &;code = 38
char = #;code = 35
char = x;code = 120
char = 3;code = 51
char = b;code = 98
char = c;code = 99
char = ;;code = 59
char = M;code = 77
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = s;code = 115
char = p;code = 112
char = l;code = 108
char = a;code = 97
char = y;code = 121
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = m;code = 109
char = a;code = 97
char = x;code = 120
char = i;code = 105
char = m;code = 109
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = g;code = 103
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = H;code = 72
char = T;code = 84
char = -;code = 45
char = 2;code = 50
char = 9;code = 57
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = .;code = 46
char = ;code = 32
char = C;code = 67
char = o;code = 111
char = m;code = 109
char = p;code = 112
char = l;code = 108
char = e;code = 101
char = x;code = 120
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = y;code = 121
char = c;code = 99
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = r;code = 114
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = t;code = 116
char = ;code = 32
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = G;code = 71
char = 2;code = 50
char = /;code = 47
char = M;code = 77
char = ;code = 32
char = p;code = 112
char = h;code = 104
char = a;code = 97
char = s;code = 115
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = s;code = 115
char = u;code = 117
char = b;code = 98
char = s;code = 115
char = e;code = 101
char = q;code = 113
char = u;code = 117
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = i;code = 105
char = g;code = 103
char = g;code = 103
char = e;code = 101
char = r;code = 114
char = ;code = 32
char = d;code = 100
char = o;code = 111
char = s;code = 115
char = e;code = 101
char = -;code = 45
char = d;code = 100
char = e;code = 101
char = p;code = 112
char = e;code = 101
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = p;code = 112
char = o;code = 111
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = h;code = 104
char = i;code = 105
char = c;code = 99
char = h;code = 104
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = b;code = 98
char = t;code = 116
char = a;code = 97
char = i;code = 105
char = n;code = 110
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = p;code = 112
char = o;code = 111
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = a;code = 97
char = l;code = 108
char = y;code = 121
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = v;code = 118
char = i;code = 105
char = a;code = 97
char = ;code = 32
char = f;code = 102
char = l;code = 108
char = o;code = 111
char = w;code = 119
char = ;code = 32
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = o;code = 111
char = m;code = 109
char = e;code = 101
char = t;code = 116
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = f;code = 102
char = o;code = 111
char = c;code = 99
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = r;code = 114
char = o;code = 111
char = s;code = 115
char = c;code = 99
char = o;code = 111
char = p;code = 112
char = y;code = 121
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = s;code = 115
char = a;code = 97
char = y;code = 121
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = B;code = 66
char = e;code = 101
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = f;code = 102
char = l;code = 108
char = u;code = 117
char = o;code = 111
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = c;code = 99
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = 1;code = 49
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = -;code = 45
char = <;code = 60
char = b;code = 98
char = >;code = 62
char = 4;code = 52
char = <;code = 60
char = /;code = 47
char = b;code = 98
char = >;code = 62
char = ;code = 32
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = b;code = 98
char = s;code = 115
char = e;code = 101
char = r;code = 114
char = v;code = 118
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = t;code = 116
char = a;code = 97
char = r;code = 114
char = g;code = 103
char = e;code = 101
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = t;code = 116
char = o;code = 111
char = c;code = 99
char = h;code = 104
char = o;code = 111
char = n;code = 110
char = d;code = 100
char = r;code = 114
char = i;code = 105
char = a;code = 97
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = e;code = 101
char = x;code = 120
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = ;code = 32
char = d;code = 100
char = i;code = 105
char = s;code = 115
char = r;code = 114
char = u;code = 117
char = p;code = 112
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = m;code = 109
char = i;code = 105
char = t;code = 116
char = o;code = 111
char = c;code = 99
char = h;code = 104
char = o;code = 111
char = n;code = 110
char = d;code = 100
char = r;code = 114
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ;code = 32
char = m;code = 109
char = e;code = 101
char = m;code = 109
char = b;code = 98
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = t;code = 116
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = i;code = 105
char = a;code = 97
char = l;code = 108
char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = h;code = 104
char = i;code = 105
char = c;code = 99
char = h;code = 104
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = e;code = 101
char = q;code = 113
char = u;code = 117
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = u;code = 117
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = v;code = 118
char = e;code = 101
char = r;code = 114
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = x;code = 120
char = y;code = 121
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = p;code = 112
char = e;code = 101
char = c;code = 99
char = i;code = 105
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = c;code = 99
char = e;code = 101
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = p;code = 112
char = o;code = 111
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = s;code = 115
char = i;code = 105
char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = >;code = 62
result sql = Four new oxidovanadium [V^VOL^1-4(ema)] complexes (1-4) have been synthesized using tridentate binegative ONO donor ligands H₂L^1-4 [H₂L¹: (E)-N'-(2-hydroxybenzylidene)furan-2-carbohydrazide; H₂L²: (E)-N'-(4-(diethylamino)-2-hydroxybenzylidene)thiophene-2-carbohydrazide; H₂L³: (E)-2-(4-(diethylamino)-2-hydroxybenzylideneamino)-4-methylphenol; H₂L⁴: (E)-2-(3-ethoxy-2-hydroxybenzylideneamino)-4-methylphenol] and ethyl maltol (Hema) as a bidentate uninegative coligand and characterized by CHNS analysis, IR, UV-vis, NMR, and HR-ESI-MS methods. The structures of 1, 3, and 4 are confirmed by single-crystal X-ray analysis. The hydrophobicity and hydrolytic stability of the complexes are tested using NMR and HR-ESI-MS and correlated with their observed biological activities. It is observed that 1 hydrolyzed into a penta-coordinated vanadium-hydroxyl species (V^VOL¹-OH) with the release of ethyl maltol, whereas 2-4 are found quite stable under the investigated time period. The biomolecular interaction of 1-4 with DNA and BSA was performed using absorbance, fluorescence, and circular dichroism techniques. The in vitro cytotoxicity activities of H₂L^1-4 and 1-4 were tested against A549, HT-29, and NIH-3T3 cell lines. Among complexes, 2 with an IC₅₀ value of 4.4 ± 0.1 μM displayed maximum anticancer activity against the HT-29 cell line. Complexes induce cell cycle arrest at the G2/M phase and subsequently trigger dose-dependent cell apoptosis, which is obtained by the cell apoptosis analysis via flow cytometry and confocal microscopy assays. Being fluorescence active, 1-4 were observed to target the mitochondria and exhibit disruption of the mitochondrial membrane potential, which consequently causes overproduction of intracellular reactive oxygen species and induced cell apoptosis.

Publication: Inorg Chem 2023 Apr
Publication Date: Apr 2023
Study Author(s): Sahu Gurunath G ; Patra Sushree Aradhana SA ; Pattanayak Pratikshya Das PD ; Kaminsky Werner W ; Dinda Rupam R ;
Institution: Department of Chemistry, National Institute of Technology, Rourkela, 769008 Odisha, India.
Shortcut link to this study:

Four new oxidovanadium [V^VOL^1-4(ema)] complexes (1-4) have been synthesized using tridentate binegative ONO donor ligands H₂L^1-4 [H₂L¹: (E)-N'-(2-hydroxybenzylidene)furan-2-carbohydrazide; H₂L²: (E)-N'-(4-(diethylamino)-2-hydroxybenzylidene)thiophene-2-carbohydrazide; H₂L³: (E)-2-(4-(diethylamino)-2-hydroxybenzylideneamino)-4-methylphenol; H₂L⁴: (E)-2-(3-ethoxy-2-hydroxybenzylideneamino)-4-methylphenol] and ethyl maltol (Hema) as a bidentate uninegative coligand and characterized by CHNS analysis, IR, UV-vis, NMR, and HR-ESI-MS methods. The structures of 1, 3, and 4 are confirmed by single-crystal X-ray analysis. The hydrophobicity and hydrolytic stability of the complexes are tested using NMR and HR-ESI-MS and correlated with their observed biological activities. It is observed that 1 hydrolyzed into a penta-coordinated vanadium-hydroxyl species (V^VOL¹-OH) with the release of ethyl maltol, whereas 2-4 are found quite stable under the investigated time period. The biomolecular interaction of 1-4 with DNA and BSA was performed using absorbance, fluorescence, and circular dichroism techniques. The in vitro cytotoxicity activities of H₂L^1-4 and 1-4 were tested against A549, HT-29, and NIH-3T3 cell lines. Among complexes, 2 with an IC₅₀ value of 4.4 ± 0.1 μM displayed maximum anticancer activity against the HT-29 cell line. Complexes induce cell cycle arrest at the G2/M phase and subsequently trigger dose-dependent cell apoptosis, which is obtained by the cell apoptosis analysis via flow cytometry and confocal microscopy assays. Being fluorescence active, 1-4 were observed to target the mitochondria and exhibit disruption of the mitochondrial membrane potential, which consequently causes overproduction of intracellular reactive oxygen species and induced cell apoptosis.

PMID: 37074879

Click here for more animal production studies »

Have comments? Post them here:

comments powered by Disqus

This site is part of the Natural News Network © 2013 All Rights Reserved. Privacy | Terms All content posted on this site is commentary or opinion and is protected under Free Speech. Truth Publishing International, LTD. is not responsible for content written by contributing authors. The information on this site is provided for educational and entertainment purposes only. It is not intended as a substitute for professional advice of any kind. Truth Publishing assumes no responsibility for the use or misuse of this material. Your use of this website indicates your agreement to these terms and those published here. All trademarks, registered trademarks and servicemarks mentioned on this site are the property of their respective owners.

	Profiteering cancer industry ripped wide open by explosive documentary 'Cut, Poison, Burn' - watch preview here
	Study shows aggressive end-of-life treatments lead to needlessly horrific deaths in middle-aged, terminal cancer patients
	Good health is no accident
	Angelina Jolie, corporate patents on genes, and the U.S. Supreme Court
	Vitamin D treatment for deadliest form of breast cancer
	Angelina Jolie's double mastectomy has caused exaggerated fear and confusion for many women
	BPA exposure programs unborn babies to have breast cancer later in life
	Eating cranberries could help defeat cancer
	Cancer screenings are now spreading deadly superbugs, say reports
	Reduce the risk of cancer with probiotics
	More than 95% accurate, this early detection cancer test could save your life without the risk of radiological screenings
	Five year update on the guy who cured his stage IV prostate cancer with baking soda
	The hard cost of amnesty: $6.3 trillion in benefits handed out to illegals
	Healthy, anti-inflammatory gut bacteria is actually key to averting the start of cancer
	U.S. healthcare system collapsing into massive FRAUD network of criminal cancer doctors, hospice executives and con artist physicians

Have comments? Post them here:

Related Concepts

Related Articles