|
|
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result sql = Autonomic reflexes and the cardiovascular effects of propylene glycol.
Autonomic reflexes and the cardiovascular effects of propylene glycol.char = T;code = 84
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char = f;code = 102
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char = r;code = 114
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char = e;code = 101
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char = m;code = 109
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char = m;code = 109
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char = H;code = 72
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char = a;code = 97
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char = 0;code = 48
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char = 8;code = 56
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char = 0;code = 48
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char = i;code = 105
char = a;code = 97
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char = r;code = 114
char = e;code = 101
char = s;code = 115
char = s;code = 115
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = ,;code = 44
char = ;code = 32
char = w;code = 119
char = h;code = 104
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = y;code = 121
char = m;code = 109
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = b;code = 98
char = l;code = 108
char = o;code = 111
char = c;code = 99
char = k;code = 107
char = a;code = 97
char = d;code = 100
char = e;code = 101
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = b;code = 98
char = r;code = 114
char = e;code = 101
char = t;code = 116
char = y;code = 121
char = l;code = 108
char = i;code = 105
char = u;code = 117
char = m;code = 109
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = s;code = 115
char = y;code = 121
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = h;code = 104
char = a;code = 97
char = d;code = 100
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = t;code = 116
char = t;code = 116
char = l;code = 108
char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = .;code = 46
char = ;code = 32
char = I;code = 73
char = t;code = 116
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = c;code = 99
char = o;code = 111
char = n;code = 110
char = c;code = 99
char = l;code = 108
char = u;code = 117
char = d;code = 100
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = p;code = 112
char = y;code = 121
char = l;code = 108
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = l;code = 108
char = y;code = 121
char = c;code = 99
char = o;code = 111
char = l;code = 108
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = u;code = 117
char = s;code = 115
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = p;code = 112
char = o;code = 111
char = w;code = 119
char = e;code = 101
char = r;code = 114
char = f;code = 102
char = u;code = 117
char = l;code = 108
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = f;code = 102
char = l;code = 108
char = e;code = 101
char = x;code = 120
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = i;code = 105
char = m;code = 109
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = d;code = 100
char = i;code = 105
char = o;code = 111
char = m;code = 109
char = o;code = 111
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = v;code = 118
char = a;code = 97
char = g;code = 103
char = u;code = 117
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = n;code = 110
char = s;code = 115
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = h;code = 104
char = i;code = 105
char = b;code = 98
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = s;code = 115
char = y;code = 121
char = m;code = 109
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = t;code = 116
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = i;code = 105
char = n;code = 110
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char = 5;code = 53
char = ;code = 32
char = s;code = 115
char = ;code = 32
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char = f;code = 102
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = j;code = 106
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ,;code = 44
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = o;code = 111
char = r;code = 114
char = i;code = 105
char = g;code = 103
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = f;code = 102
char = l;code = 108
char = e;code = 101
char = x;code = 120
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = l;code = 108
char = i;code = 105
char = k;code = 107
char = e;code = 101
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = t;code = 116
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = h;code = 104
char = o;code = 111
char = r;code = 114
char = a;code = 97
char = c;code = 99
char = i;code = 105
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char = >;code = 62
result sql = The effect of i.v. propylene glycol in doses of 160-800 mg kg-1 on heart rate, arterial pressure and efferent sympathetic activity were observed in anaesthetized paralysed, artificially ventilated dogs. Within 3-5 s of the commencement of the injection of propylene glycol there was an immediate mean decrease in heart rate of 22.7 and 72.1 beat min-1 and in arterial pressure of 27.2 and 58.8 mm Hg at doses of 400 mg kg-1 and 800 mg kg-1, respectively, together with a gross reduction of sympathetic activity and a subsequent increase in heart rate above control values. All these effects were transient and at a dose of propylene glycol 800 mg kg-1, heart rate and arterial pressure returned to control values by 1 min, and sympathetic activity by 2 min. Blocking the vagus nerves with atropine prevented the observed changes in heart rate and arterial pressure, whereas sympathetic blockade with bretylium tosylate had little effect. It was concluded that propylene glycol causes powerful reflex stimulation of the cardiomotor vagus and transient inhibition of efferent sympathetic activity within 5 s of injection, and that the origin of the reflex is likely to be intrathoracic.
char = u;code = 117
char = t;code = 116
char = o;code = 111
char = n;code = 110
char = o;code = 111
char = m;code = 109
char = i;code = 105
char = c;code = 99
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = f;code = 102
char = l;code = 108
char = e;code = 101
char = x;code = 120
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = d;code = 100
char = i;code = 105
char = o;code = 111
char = v;code = 118
char = a;code = 97
char = s;code = 115
char = c;code = 99
char = u;code = 117
char = l;code = 108
char = a;code = 97
char = r;code = 114
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
char = c;code = 99
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = o;code = 111
char = p;code = 112
char = y;code = 121
char = l;code = 108
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = g;code = 103
char = l;code = 108
char = y;code = 121
char = c;code = 99
char = o;code = 111
char = l;code = 108
char = .;code = 46
result sql = Autonomic reflexes and the cardiovascular effects of propylene glycol.
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char = e;code = 101
char = ;code = 32
char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
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char = t;code = 116
char = ;code = 32
char = o;code = 111
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char = ;code = 32
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char = p;code = 112
char = r;code = 114
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char = g;code = 103
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char = y;code = 121
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char = d;code = 100
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char = e;code = 101
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char = 6;code = 54
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char = 0;code = 48
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char = ;code = 32
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char = m;code = 109
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char = a;code = 97
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result sql = The effect of i.v. propylene glycol in doses of 160-800 mg kg-1 on heart rate, arterial pressure and efferent sympathetic activity were observed in anaesthetized paralysed, artificially ventilated dogs. Within 3-5 s of the commencement of the injection of propylene glycol there was an immediate mean decrease in heart rate of 22.7 and 72.1 beat min-1 and in arterial pressure of 27.2 and 58.8 mm Hg at doses of 400 mg kg-1 and 800 mg kg-1, respectively, together with a gross reduction of sympathetic activity and a subsequent increase in heart rate above control values. All these effects were transient and at a dose of propylene glycol 800 mg kg-1, heart rate and arterial pressure returned to control values by 1 min, and sympathetic activity by 2 min. Blocking the vagus nerves with atropine prevented the observed changes in heart rate and arterial pressure, whereas sympathetic blockade with bretylium tosylate had little effect. It was concluded that propylene glycol causes powerful reflex stimulation of the cardiomotor vagus and transient inhibition of efferent sympathetic activity within 5 s of injection, and that the origin of the reflex is likely to be intrathoracic.
Publication: Br J Anaesth 1986 Aug ;58(8)::897-902.
Publication Date: 1986 Aug
Study Author(s): Al-Khudhairi, D;Whitwam, J G;
Institution:
Shortcut link to this study:
Publication Date: 1986 Aug
Study Author(s): Al-Khudhairi, D;Whitwam, J G;
Institution:
Shortcut link to this study:
The effect of i.v. propylene glycol in doses of 160-800 mg kg-1 on heart rate, arterial pressure and efferent sympathetic activity were observed in anaesthetized paralysed, artificially ventilated dogs. Within 3-5 s of the commencement of the injection of propylene glycol there was an immediate mean decrease in heart rate of 22.7 and 72.1 beat min-1 and in arterial pressure of 27.2 and 58.8 mm Hg at doses of 400 mg kg-1 and 800 mg kg-1, respectively, together with a gross reduction of sympathetic activity and a subsequent increase in heart rate above control values. All these effects were transient and at a dose of propylene glycol 800 mg kg-1, heart rate and arterial pressure returned to control values by 1 min, and sympathetic activity by 2 min. Blocking the vagus nerves with atropine prevented the observed changes in heart rate and arterial pressure, whereas sympathetic blockade with bretylium tosylate had little effect. It was concluded that propylene glycol causes powerful reflex stimulation of the cardiomotor vagus and transient inhibition of efferent sympathetic activity within 5 s of injection, and that the origin of the reflex is likely to be intrathoracic.
PMID: 3730237
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