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result sql = Design, synthesis, and anti-oomycete activity of 3-acyloxymaltol/ethyl maltol derivatives.
Design, synthesis, and anti-oomycete activity of 3-acyloxymaltol/ethyl maltol derivatives.
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char = e;code = 101
char = ;code = 32
char = m;code = 109
char = o;code = 111
char = d;code = 100
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = e;code = 101
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = >;code = 62
result sql = Twenty 3-acyloxymaltol/ethyl maltol derivatives (7a-j and 8a-j) were synthesized and evaluated in vitro for their anti-oomycete activity against Phytophthora capsici, respectively. Among all of twenty derivatives, more than half of the compounds 7f, 7h, 8a-h and 8j had anti-oomycete activity higher than the positive control zoxamide (EC₅₀ = 22.23 mg/L), and the EC₅₀ values of 18.66, 20.32, 12.80, 16.18, 10.59, 14.98, 16.80, 10.36, 15.32, 12.64, and 13.59 mg/L, respectively. Especially, compounds 8c and 8f exhibited the best anti-oomycete activity against P. capsici with EC₅₀ values of 10.59 and 10.36 mg/L, respectively. Overall, hydroxyl group of maltol/ethyl maltol is important active modification site.

Publication: J Asian Nat Prod Res 2024 Jun:1-9.
Publication Date: Jun 2024
Study Author(s): Guo Yi-Hao YH ; Liu Yi-Bo YB ; Ma Ying-Ying YY ; Li Yan Y ; Tian Yue-E YE ; Huang Xiao-Bo XB ; Qian Le L ; Liu Sheng-Ming SM ; Chen Gen-Qiang GQ ; Che Zhi-Ping ZP ;
Institution: Laboratory of Pesticidal Design & Synthesis, Department of Plant Protection, College of Horticultrue and Plant Protection, Henan University of Science and Technology, Luoyang 471023, China.
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Twenty 3-acyloxymaltol/ethyl maltol derivatives (7a-j and 8a-j) were synthesized and evaluated in vitro for their anti-oomycete activity against Phytophthora capsici, respectively. Among all of twenty derivatives, more than half of the compounds 7f, 7h, 8a-h and 8j had anti-oomycete activity higher than the positive control zoxamide (EC₅₀ = 22.23 mg/L), and the EC₅₀ values of 18.66, 20.32, 12.80, 16.18, 10.59, 14.98, 16.80, 10.36, 15.32, 12.64, and 13.59 mg/L, respectively. Especially, compounds 8c and 8f exhibited the best anti-oomycete activity against P. capsici with EC₅₀ values of 10.59 and 10.36 mg/L, respectively. Overall, hydroxyl group of maltol/ethyl maltol is important active modification site.

PMID: 38859556

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