char = C;code = 67
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char = l;code = 108
char = l;code = 108
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char = m;code = 109
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char = g;code = 103
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char = f;code = 102
char = o;code = 111
char = l;code = 108
char = l;code = 108
char = o;code = 111
char = w;code = 119
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char = i;code = 105
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char = r;code = 114
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char = t;code = 116
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char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = c;code = 99
char = i;code = 105
char = n;code = 110
char = o;code = 111
char = g;code = 103
char = e;code = 101
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char = s;code = 115
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char = a;code = 97
char = n;code = 110
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = u;code = 117
char = t;code = 116
char = y;code = 121
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char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = h;code = 104
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char = d;code = 100
char = r;code = 114
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char = x;code = 120
char = y;code = 121
char = t;code = 116
char = o;code = 111
char = l;code = 108
char = u;code = 117
char = e;code = 101
char = n;code = 110
char = e;code = 101
char = .;code = 46
result sql = Cell kinetics in mouse lung following administration of carcinogens and butylated hydroxytoluene.
Cell kinetics in mouse lung following administration of carcinogens and butylated hydroxytoluene.
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char = m;code = 109
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char = s;code = 115
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char = d;code = 100
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char = e;code = 101
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char = a;code = 97
char = n;code = 110
char = c;code = 99
char = e;code = 101
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char = t;code = 116
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char = f;code = 102
char = ;code = 32
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char = l;code = 108
char = d;code = 100
char = ;code = 32
char = o;code = 111
char = c;code = 99
char = c;code = 99
char = u;code = 117
char = r;code = 114
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = p;code = 112
char = e;code = 101
char = n;code = 110
char = d;code = 100
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = l;code = 108
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char = f;code = 102
char = ;code = 32
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char = e;code = 101
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char = a;code = 97
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char = l;code = 108
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char = a;code = 97
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char = .;code = 46
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char = M;code = 77
char = a;code = 97
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char = e;code = 101
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char = A;code = 65
char = /;code = 47
char = J;code = 74
char = ;code = 32
char = m;code = 109
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char = c;code = 99
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char = w;code = 119
char = e;code = 101
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char = g;code = 103
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char = e;code = 101
char = n;code = 110
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char = 1;code = 49
char = 0;code = 48
char = 0;code = 48
char = 0;code = 48
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char = m;code = 109
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char = k;code = 107
char = g;code = 103
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char = o;code = 111
char = f;code = 102
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char = 3;code = 51
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char = l;code = 108
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char = n;code = 110
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = M;code = 77
char = C;code = 67
char = A;code = 65
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char = .;code = 46
char = ;code = 32
char = A;code = 65
char = l;code = 108
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char = e;code = 101
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char = l;code = 108
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char = e;code = 101
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char = e;code = 101
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char = o;code = 111
char = u;code = 117
char = g;code = 103
char = h;code = 104
char = ;code = 32
char = c;code = 99
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char = n;code = 110
char = t;code = 116
char = i;code = 105
char = n;code = 110
char = u;code = 117
char = o;code = 111
char = u;code = 117
char = s;code = 115
char = ;code = 32
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char = u;code = 117
char = s;code = 115
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char = ;code = 32
char = [;code = 91
char = 3;code = 51
char = H;code = 72
char = ];code = 93
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char = h;code = 104
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char = d;code = 100
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char = e;code = 101
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char = 6;code = 54
char = ;code = 32
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char = o;code = 111
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char = ;code = 32
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char = c;code = 99
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char = c;code = 99
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char = n;code = 110
char = o;code = 111
char = g;code = 103
char = e;code = 101
char = n;code = 110
char = .;code = 46
char = ;code = 32
char = U;code = 85
char = r;code = 114
char = e;code = 101
char = t;code = 116
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = ;code = 32
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char = I;code = 73
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char = M;code = 77
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char = f;code = 102
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char = e;code = 101
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char = i;code = 105
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char = f;code = 102
char = e;code = 101
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char = a;code = 97
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char = d;code = 100
char = w;code = 119
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char = e;code = 101
char = d;code = 100
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char = a;code = 97
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char = p;code = 112
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char = b;code = 98
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char = g;code = 103
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char = a;code = 97
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char = v;code = 118
char = e;code = 101
char = l;code = 108
char = o;code = 111
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char = m;code = 109
char = e;code = 101
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char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = d;code = 100
char = a;code = 97
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char = a;code = 97
char = ;code = 32
char = d;code = 100
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char = o;code = 111
char = t;code = 116
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char = a;code = 97
char = l;code = 108
char = l;code = 108
char = o;code = 111
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char = ;code = 32
char = e;code = 101
char = x;code = 120
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char = u;code = 117
char = s;code = 115
char = i;code = 105
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char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
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char = l;code = 108
char = v;code = 118
char = e;code = 101
char = o;code = 111
char = l;code = 108
char = a;code = 97
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char = e;code = 101
char = l;code = 108
char = l;code = 108
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char = h;code = 104
char = y;code = 121
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char = e;code = 101
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char = p;code = 112
char = l;code = 108
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char = i;code = 105
char = a;code = 97
char = ;code = 32
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = a;code = 97
char = ;code = 32
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char = c;code = 99
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = i;code = 105
char = s;code = 115
char = m;code = 109
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = B;code = 66
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
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char = n;code = 110
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char = ;code = 32
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char = g;code = 103
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char = t;code = 116
char = u;code = 117
char = m;code = 109
char = o;code = 111
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char = d;code = 100
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = l;code = 108
char = o;code = 111
char = p;code = 112
char = m;code = 109
char = e;code = 101
char = n;code = 110
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result sql = A series of experiments is described which was designed to test the hypothesis that, in mouse lung, enhancement of tumor development could occur independently of overall alveolar cell hyperplasia. Male A/J mice were given 1000 mg/kg of urethan or 10 mg/kg of 3-methylcholanthrene (MCA). Alveolar cells were labeled through continuous infusion of [3H]thymidine for 6 weeks after administration of the carcinogen. Urethan produced a significant hyperplasia of the type II alveolar cell population, whereas MCA had no such effect. Five repeated injections of 300 mg/kg of butylated hydroxytoluene (BHT), a procedure known to enhance lung tumor development, produced cell hyperplasia only during the first 2 weeks; later the mice became resistant to the action of BHT. In animals treated with piperonyl butoxide prior to BHT, cell proliferation was abolished. BHT still had a small but significant enhancing effect on tumor development. However, this effect was dwarfed by the observation that piperonyl butoxide alone greatly inhibited tumor development. The data do not allow exclusion of alveolar cell hyperplasia as a mechanism in BHT-mediated enhancement of mouse lung tumor development.

Publication: Toxicol. Appl. Pharmacol. 1985 May ;78(3)::464-72.
Publication Date: 1985 May
Study Author(s): Witschi, H P;Morse, C C;
Institution:
Shortcut link to this study:
A series of experiments is described which was designed to test the hypothesis that, in mouse lung, enhancement of tumor development could occur independently of overall alveolar cell hyperplasia. Male A/J mice were given 1000 mg/kg of urethan or 10 mg/kg of 3-methylcholanthrene (MCA). Alveolar cells were labeled through continuous infusion of [3H]thymidine for 6 weeks after administration of the carcinogen. Urethan produced a significant hyperplasia of the type II alveolar cell population, whereas MCA had no such effect. Five repeated injections of 300 mg/kg of butylated hydroxytoluene (BHT), a procedure known to enhance lung tumor development, produced cell hyperplasia only during the first 2 weeks; later the mice became resistant to the action of BHT. In animals treated with piperonyl butoxide prior to BHT, cell proliferation was abolished. BHT still had a small but significant enhancing effect on tumor development. However, this effect was dwarfed by the observation that piperonyl butoxide alone greatly inhibited tumor development. The data do not allow exclusion of alveolar cell hyperplasia as a mechanism in BHT-mediated enhancement of mouse lung tumor development.
PMID: 4049395

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