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result sql = Changes in fatty acid composition of the single platelet phospholipids induced by pantethine treatment.
Changes in fatty acid composition of the single platelet phospholipids induced by pantethine treatment.
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char = ;code = 32
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char = e;code = 101
char = t;code = 116
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char = n;code = 110
char = e;code = 101
char = ;code = 32
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char = o;code = 111
char = t;code = 116
char = ;code = 32
char = o;code = 111
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char = y;code = 121
char = ;code = 32
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char = ;code = 32
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char = ;code = 32
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char = l;code = 108
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char = ;code = 32
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char = d;code = 100
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char = i;code = 105
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char = ;code = 32
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char = d;code = 100
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char = i;code = 105
char = c;code = 99
char = ;code = 32
char = p;code = 112
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char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
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result sql = In a single-blind cross-over study the effect of oral treatment with pantethine on plasma and platelet lipid composition was evaluated in 20 patients with dyslipidaemia (7 IIa, 7 IIb and 6 Iv type). In plasma significant decreases of total cholesterol and triglycerides with increase of high density lipoprotein-cholesterol were observed. In platelets pantethine treatment significantly reduced phospholipid and cholesterol content. In addition gas-chromatographic analysis showed a reduction of saturated and monounsaturated and a relative increase of polyunsaturated fatty acid content of platelet phospholipids. A selective relative increase was observed of some n-3 polyunsaturated fatty acids like eicosapentaenoic and docosahexaenoic acid whereas arachidonic acid decreased. The present study indicates a favourable influence of pantethine not only on plasma but also on platelet lipids which could be of value in delaying the development of atherosclerosis in dyslipidaemic patients.

Publication: Int J Clin Pharmacol Res 1985 ;5(5)::309-18.
Publication Date: 1985
Study Author(s): Gensini, G F;Prisco, D;Rogasi, P G;Matucci, M;Neri Serneri, G G;
Institution:
Shortcut link to this study:
In a single-blind cross-over study the effect of oral treatment with pantethine on plasma and platelet lipid composition was evaluated in 20 patients with dyslipidaemia (7 IIa, 7 IIb and 6 Iv type). In plasma significant decreases of total cholesterol and triglycerides with increase of high density lipoprotein-cholesterol were observed. In platelets pantethine treatment significantly reduced phospholipid and cholesterol content. In addition gas-chromatographic analysis showed a reduction of saturated and monounsaturated and a relative increase of polyunsaturated fatty acid content of platelet phospholipids. A selective relative increase was observed of some n-3 polyunsaturated fatty acids like eicosapentaenoic and docosahexaenoic acid whereas arachidonic acid decreased. The present study indicates a favourable influence of pantethine not only on plasma but also on platelet lipids which could be of value in delaying the development of atherosclerosis in dyslipidaemic patients.
PMID: 4066081

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