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char = S;code = 83
char = a;code = 97
char = f;code = 102
char = e;code = 101
char = t;code = 116
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char = o;code = 111
char = f;code = 102
char = ;code = 32
char = B;code = 66
char = a;code = 97
char = k;code = 107
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = E;code = 69
char = g;code = 103
char = g;code = 103
char = ,;code = 44
char = ;code = 32
char = E;code = 69
char = g;code = 103
char = g;code = 103
char = ;code = 32
char = Y;code = 89
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char = a;code = 97
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char = d;code = 100
char = ;code = 32
char = E;code = 69
char = g;code = 103
char = g;code = 103
char = ;code = 32
char = W;code = 87
char = h;code = 104
char = i;code = 105
char = t;code = 116
char = e;code = 101
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char = i;code = 105
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char = Y;code = 89
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char = e;code = 101
char = n;code = 110
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char = ;code = 32
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char = g;code = 103
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char = A;code = 65
char = l;code = 108
char = l;code = 108
char = e;code = 101
char = r;code = 114
char = g;code = 103
char = y;code = 121
char = .;code = 46
result sql = Comparative Safety of Baked Egg, Egg Yolk, and Egg White in Young Children with Egg Allergy.
Comparative Safety of Baked Egg, Egg Yolk, and Egg White in Young Children with Egg Allergy.
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char = a;code = 97
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char = e;code = 101
char = d;code = 100
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char = e;code = 101
char = g;code = 103
char = g;code = 103
char = ;code = 32
char = (;code = 40
char = B;code = 66
char = E;code = 69
char = );code = 41
char = ;code = 32
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = g;code = 103
char = e;code = 101
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char = e;code = 101
char = r;code = 114
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = y;code = 121
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char = w;code = 119
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char = l;code = 108
char = l;code = 108
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = l;code = 108
char = e;code = 101
char = r;code = 114
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = b;code = 98
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char = c;code = 99
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char = i;code = 105
char = l;code = 108
char = d;code = 100
char = r;code = 114
char = e;code = 101
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char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = e;code = 101
char = g;code = 103
char = g;code = 103
char = ;code = 32
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = e;code = 101
char = r;code = 114
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char = y;code = 121
char = ,;code = 44
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char = g;code = 103
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char = k;code = 107
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char = (;code = 40
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char = );code = 41
char = ;code = 32
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char = c;code = 99
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char = s;code = 115
char = i;code = 105
char = d;code = 100
char = e;code = 101
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = l;code = 108
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char = s;code = 115
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char = l;code = 108
char = e;code = 101
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char = g;code = 103
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char = i;code = 105
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char = n;code = 110
char = ;code = 32
char = e;code = 101
char = g;code = 103
char = g;code = 103
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char = w;code = 119
char = h;code = 104
char = i;code = 105
char = t;code = 116
char = e;code = 101
char = ;code = 32
char = (;code = 40
char = E;code = 69
char = W;code = 87
char = );code = 41
char = .;code = 46
char = ;code = 32
char = A;code = 65
char = l;code = 108
char = t;code = 116
char = h;code = 104
char = o;code = 111
char = u;code = 117
char = g;code = 103
char = h;code = 104
char = ;code = 32
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char = h;code = 104
char = e;code = 101
char = s;code = 115
char = e;code = 101
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char = f;code = 102
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char = g;code = 103
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char = b;code = 98
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char = h;code = 104
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char = B;code = 66
char = E;code = 69
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char = a;code = 97
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char = E;code = 69
char = Y;code = 89
char = ;code = 32
char = m;code = 109
char = a;code = 97
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char = b;code = 98
char = e;code = 101
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char = s;code = 115
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char = e;code = 101
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char = o;code = 111
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char = s;code = 115
char = ;code = 32
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char = o;code = 111
char = r;code = 114
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char = r;code = 114
char = e;code = 101
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char = ,;code = 44
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char = d;code = 100
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char = e;code = 101
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char = r;code = 114
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char = s;code = 115
char = a;code = 97
char = f;code = 102
char = e;code = 101
char = t;code = 116
char = y;code = 121
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char = t;code = 116
char = h;code = 104
char = ;code = 32
char = e;code = 101
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char = c;code = 99
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char = r;code = 114
char = ;code = 32
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char = h;code = 104
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char = h;code = 104
char = e;code = 101
char = a;code = 97
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char = e;code = 101
char = d;code = 100
char = ;code = 32
char = E;code = 69
char = W;code = 87
char = .;code = 46
char = ;code = 32
char = T;code = 84
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = ;code = 32
char = s;code = 115
char = t;code = 116
char = u;code = 117
char = d;code = 100
char = y;code = 121
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char = a;code = 97
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char = m;code = 109
char = e;code = 101
char = d;code = 100
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char = o;code = 111
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char = m;code = 109
char = p;code = 112
char = a;code = 97
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char = e;code = 101
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char = a;code = 97
char = f;code = 102
char = e;code = 101
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char = y;code = 121
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char = o;code = 111
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char = a;code = 97
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char = l;code = 108
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char = e;code = 101
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char = (;code = 40
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char = C;code = 67
char = );code = 41
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char = r;code = 114
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char = n;code = 110
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char = r;code = 114
char = o;code = 111
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char = u;code = 117
char = c;code = 99
char = i;code = 105
char = n;code = 110
char = g;code = 103
char = ;code = 32
char = B;code = 66
char = E;code = 69
char = ,;code = 44
char = ;code = 32
char = E;code = 69
char = Y;code = 89
char = ,;code = 44
char = ;code = 32
char = a;code = 97
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char = ;code = 32
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char = p;code = 112
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char = e;code = 101
char = ;code = 32
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char = C;code = 67
char = ;code = 32
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char = o;code = 111
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char = t;code = 116
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char = ;code = 32
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char = a;code = 97
char = r;code = 114
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char = o;code = 111
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char = (;code = 40
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char = ;code = 32
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char = 2;code = 50
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char = ;code = 32
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char = i;code = 105
char = n;code = 110
char = ;code = 32
char = o;code = 111
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char = ;code = 32
char = g;code = 103
char = a;code = 97
char = s;code = 115
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char = r;code = 114
char = o;code = 111
char = i;code = 105
char = n;code = 110
char = t;code = 116
char = e;code = 101
char = s;code = 115
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char = n;code = 110
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char = ;code = 32
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char = e;code = 101
char = a;code = 97
char = c;code = 99
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char = i;code = 105
char = o;code = 111
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char = s;code = 115
char = ;code = 32
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char = e;code = 101
char = r;code = 114
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char = ;code = 32
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char = b;code = 98
char = s;code = 115
char = e;code = 101
char = r;code = 114
char = v;code = 118
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = E;code = 69
char = Y;code = 89
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = ,;code = 44
char = ;code = 32
char = t;code = 116
char = w;code = 119
char = o;code = 111
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = s;code = 115
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
char = ;code = 32
char = E;code = 69
char = W;code = 87
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
char = ;code = 32
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char = x;code = 120
char = p;code = 112
char = e;code = 101
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char = i;code = 105
char = e;code = 101
char = n;code = 110
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = p;code = 112
char = i;code = 105
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = s;code = 115
char = y;code = 121
char = m;code = 109
char = p;code = 112
char = t;code = 116
char = o;code = 111
char = m;code = 109
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = N;code = 78
char = o;code = 111
char = ;code = 32
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = e;code = 101
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = q;code = 113
char = u;code = 117
char = i;code = 105
char = r;code = 114
char = e;code = 101
char = d;code = 100
char = ;code = 32
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char = d;code = 100
char = r;code = 114
char = e;code = 101
char = n;code = 110
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char = i;code = 105
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char = d;code = 100
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char = r;code = 114
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = >;code = 62
char = O;code = 79
char = F;code = 70
char = C;code = 67
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = s;code = 115
char = m;code = 109
char = a;code = 97
char = l;code = 108
char = l;code = 108
char = ;code = 32
char = a;code = 97
char = m;code = 109
char = o;code = 111
char = u;code = 117
char = n;code = 110
char = t;code = 116
char = ;code = 32
char = o;code = 111
char = f;code = 102
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char = E;code = 69
char = ;code = 32
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char = e;code = 101
char = m;code = 109
char = o;code = 111
char = n;code = 110
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char = r;code = 114
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = a;code = 97
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char = l;code = 108
char = o;code = 111
char = w;code = 119
char = ;code = 32
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char = o;code = 111
char = s;code = 115
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = v;code = 118
char = i;code = 105
char = t;code = 116
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char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
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char = ;code = 32
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char = ;code = 32
char = c;code = 99
char = o;code = 111
char = u;code = 117
char = l;code = 108
char = d;code = 100
char = ;code = 32
char = b;code = 98
char = e;code = 101
char = ;code = 32
char = s;code = 115
char = a;code = 97
char = f;code = 102
char = e;code = 101
char = l;code = 108
char = y;code = 121
char = ;code = 32
char = p;code = 112
char = e;code = 101
char = r;code = 114
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = e;code = 101
char = v;code = 118
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = i;code = 105
char = l;code = 108
char = d;code = 100
char = r;code = 114
char = e;code = 101
char = n;code = 110
char = ;code = 32
char = w;code = 119
char = i;code = 105
char = t;code = 116
char = h;code = 104
char = ;code = 32
char = a;code = 97
char = ;code = 32
char = h;code = 104
char = i;code = 105
char = s;code = 115
char = t;code = 116
char = o;code = 111
char = r;code = 114
char = y;code = 121
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = e;code = 101
char = g;code = 103
char = g;code = 103
char = -;code = 45
char = i;code = 105
char = n;code = 110
char = d;code = 100
char = u;code = 117
char = c;code = 99
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = r;code = 114
char = e;code = 101
char = a;code = 97
char = c;code = 99
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = s;code = 115
char = .;code = 46
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = >;code = 62
char = <;code = 60
char = b;code = 98
char = r;code = 114
char = >;code = 62
result sql = Baked egg (BE) is generally well tolerated by children with egg allergy, and heated egg yolk (EY) is considered less allergenic than egg white (EW). Although these findings suggest that both BE and EY may be safer options for reintroduction, no studies have directly compared their safety with each other or with heated EW. This study aimed to compare the safety of oral food challenge (OFC) for reintroducing BE, EY, and EW in children with egg allergy.
We retrospectively analyzed data from patients who underwent OFCs with BE, EY, or EW at the Department of Allergy, Kanagawa Children's Medical Center, between 2014 and 2024. Only patients with a history of acute IgE-mediated allergic reactions (within 2 hours of egg ingestion), an egg white-specific IgE level ≥ 0.35 UA/mL, and strict avoidance of egg protein at the time of OFC were eligible for inclusion.
Ninety-seven children under three years of age were enrolled (BE group, n = 47; EY group, n = 23; EW group, n = 27). The OFC positive rate was significantly lower in the BE group (0%) compared to the EY (17.4%) and EW (22.2%) groups (P = 0.0011). Although mild skin or gastrointestinal reactions were observed in the EY group, two patients in the EW group experienced respiratory symptoms. No patient required adrenaline administration.
OFC with a small amount of BE demonstrated a low positivity rate, and could be safely performed even in children with a history of egg-induced reactions.


Publication: Int Arch Allergy Immunol 2025 Sep:1-13.
Publication Date: Sep 2025
Study Author(s): Ohara Yuki Y ; Matsumoto Yurika Y ; Fujita Mayumi M ; Inuo Chisato C ;
Institution:
Shortcut link to this study:
Baked egg (BE) is generally well tolerated by children with egg allergy, and heated egg yolk (EY) is considered less allergenic than egg white (EW). Although these findings suggest that both BE and EY may be safer options for reintroduction, no studies have directly compared their safety with each other or with heated EW. This study aimed to compare the safety of oral food challenge (OFC) for reintroducing BE, EY, and EW in children with egg allergy.
We retrospectively analyzed data from patients who underwent OFCs with BE, EY, or EW at the Department of Allergy, Kanagawa Children's Medical Center, between 2014 and 2024. Only patients with a history of acute IgE-mediated allergic reactions (within 2 hours of egg ingestion), an egg white-specific IgE level ≥ 0.35 UA/mL, and strict avoidance of egg protein at the time of OFC were eligible for inclusion.
Ninety-seven children under three years of age were enrolled (BE group, n = 47; EY group, n = 23; EW group, n = 27). The OFC positive rate was significantly lower in the BE group (0%) compared to the EY (17.4%) and EW (22.2%) groups (P = 0.0011). Although mild skin or gastrointestinal reactions were observed in the EY group, two patients in the EW group experienced respiratory symptoms. No patient required adrenaline administration.
OFC with a small amount of BE demonstrated a low positivity rate, and could be safely performed even in children with a history of egg-induced reactions.

PMID: 40901760

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