|
|
char = P;code = 80
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char = i;code = 105
char = a;code = 97
char = t;code = 116
char = i;code = 105
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char = t;code = 116
char = y;code = 121
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
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char = o;code = 111
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char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = i;code = 105
char = m;code = 109
char = a;code = 97
char = r;code = 114
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char = l;code = 108
char = t;code = 116
char = u;code = 117
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char = o;code = 111
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char = l;code = 108
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char = r;code = 114
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char = h;code = 104
char = e;code = 101
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char = o;code = 111
char = c;code = 99
char = y;code = 121
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char = e;code = 101
char = s;code = 115
char = .;code = 46
result sql = Potentiation of chlorinated hydrocarbon toxicity by 2,5-hexanedione in primary cultures of adult rat hepatocytes.
Potentiation of chlorinated hydrocarbon toxicity by 2,5-hexanedione in primary cultures of adult rat hepatocytes.char = P;code = 80
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char = o;code = 111
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char = r;code = 114
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char = t;code = 116
char = ;code = 32
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char = o;code = 111
char = x;code = 120
char = i;code = 105
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char = i;code = 105
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char = y;code = 121
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char = b;code = 98
char = y;code = 121
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char = i;code = 105
char = c;code = 99
char = ;code = 32
char = k;code = 107
char = e;code = 101
char = t;code = 116
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = s;code = 115
char = .;code = 46
char = ;code = 32
char = M;code = 77
char = a;code = 97
char = l;code = 108
char = e;code = 101
char = ;code = 32
char = S;code = 83
char = p;code = 112
char = r;code = 114
char = a;code = 97
char = g;code = 103
char = u;code = 117
char = e;code = 101
char = -;code = 45
char = D;code = 68
char = a;code = 97
char = w;code = 119
char = l;code = 108
char = e;code = 101
char = y;code = 121
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = s;code = 115
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char = w;code = 119
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char = o;code = 111
char = r;code = 114
char = ;code = 32
char = 2;code = 50
char = ,;code = 44
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char = h;code = 104
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char = x;code = 120
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char = D;code = 68
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char = ';code = 39
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char = M;code = 77
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char = r;code = 114
char = e;code = 101
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
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char = r;code = 114
char = a;code = 97
char = t;code = 116
char = s;code = 115
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char = ;code = 32
char = I;code = 73
char = n;code = 110
char = ;code = 32
char = a;code = 97
char = d;code = 100
char = d;code = 100
char = i;code = 105
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
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char = ;code = 32
char = c;code = 99
char = h;code = 104
char = l;code = 108
char = o;code = 111
char = r;code = 114
char = o;code = 111
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = ;code = 32
char = w;code = 119
char = a;code = 97
char = s;code = 115
char = ;code = 32
char = s;code = 115
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char = g;code = 103
char = n;code = 110
char = i;code = 105
char = f;code = 102
char = i;code = 105
char = c;code = 99
char = a;code = 97
char = n;code = 110
char = t;code = 116
char = l;code = 108
char = y;code = 121
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char = m;code = 109
char = o;code = 111
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char = e;code = 101
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char = o;code = 111
char = x;code = 120
char = i;code = 105
char = c;code = 99
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char = t;code = 116
char = h;code = 104
char = a;code = 97
char = n;code = 110
char = ;code = 32
char = d;code = 100
char = e;code = 101
char = u;code = 117
char = t;code = 116
char = e;code = 101
char = r;code = 114
char = o;code = 111
char = -;code = 45
char = c;code = 99
char = h;code = 104
char = l;code = 108
char = o;code = 111
char = r;code = 114
char = o;code = 111
char = f;code = 102
char = o;code = 111
char = r;code = 114
char = m;code = 109
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = e;code = 101
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char = ;code = 32
char = f;code = 102
char = r;code = 114
char = o;code = 111
char = m;code = 109
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char = e;code = 101
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char = r;code = 114
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char = o;code = 111
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char = l;code = 108
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char = ;code = 32
char = o;code = 111
char = r;code = 114
char = ;code = 32
char = H;code = 72
char = D;code = 68
char = -;code = 45
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char = r;code = 114
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char = t;code = 116
char = r;code = 114
char = e;code = 101
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char = e;code = 101
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char = t;code = 116
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char = r;code = 114
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char = l;code = 108
char = t;code = 116
char = u;code = 117
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char = e;code = 101
char = f;code = 102
char = u;code = 117
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char = ;code = 32
char = f;code = 102
char = o;code = 111
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char = ;code = 32
char = s;code = 115
char = t;code = 116
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char = n;code = 110
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char = k;code = 107
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char = o;code = 111
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char = d;code = 100
char = u;code = 117
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char = e;code = 101
char = d;code = 100
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char = o;code = 111
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char = l;code = 108
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char = ;code = 32
char = t;code = 116
char = o;code = 111
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char = i;code = 105
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char = ;code = 32
char = t;code = 116
char = h;code = 104
char = e;code = 101
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char = m;code = 109
char = e;code = 101
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char = m;code = 109
char = s;code = 115
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char = w;code = 119
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char = e;code = 101
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char = e;code = 101
char = f;code = 102
char = f;code = 102
char = e;code = 101
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result sql = Primary cultures of adult rat hepatocytes were used to investigate potentiation of halocarbon-induced hepatotoxicity by aliphatic ketones. Male Sprague-Dawley rats were pretreated with corn oil or 2,5-hexanedione (HD; 15 mmol/kg, po) in corn oil. Eighteen hours later the hepatocytes were isolated and cultured in Williams' Medium E and exposed to several concentrations of the hepatotoxicants carbon tetrachloride, chloroform, deutero-chloroform, or 1,1,2-trichloroethane. The cytotoxicity of these halocarbons as measured by release of the cytosolic enzyme lactate dehydrogenase into the culture medium was both time- and concentration-dependent. Halocarbon-induced cytotoxicity was exacerbated in cells isolated from HD-pretreated rats with significant increases in LDH release over cells isolated from corn oil-pretreated rats. In addition, chloroform was significantly more toxic than deutero-chloroform in hepatocytes from either corn oil- or HD-pretreated rats. Primary monolayer cultures were useful for studying ketone-induced potentiation, halocarbon-induced hepatocellular toxicity, and the mechanisms by which these effects occur.
char = o;code = 111
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char = e;code = 101
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char = t;code = 116
char = i;code = 105
char = a;code = 97
char = t;code = 116
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = c;code = 99
char = h;code = 104
char = l;code = 108
char = o;code = 111
char = r;code = 114
char = i;code = 105
char = n;code = 110
char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = h;code = 104
char = y;code = 121
char = d;code = 100
char = r;code = 114
char = o;code = 111
char = c;code = 99
char = a;code = 97
char = r;code = 114
char = b;code = 98
char = o;code = 111
char = n;code = 110
char = ;code = 32
char = t;code = 116
char = o;code = 111
char = x;code = 120
char = i;code = 105
char = c;code = 99
char = i;code = 105
char = t;code = 116
char = y;code = 121
char = ;code = 32
char = b;code = 98
char = y;code = 121
char = ;code = 32
char = 2;code = 50
char = ,;code = 44
char = 5;code = 53
char = -;code = 45
char = h;code = 104
char = e;code = 101
char = x;code = 120
char = a;code = 97
char = n;code = 110
char = e;code = 101
char = d;code = 100
char = i;code = 105
char = o;code = 111
char = n;code = 110
char = e;code = 101
char = ;code = 32
char = i;code = 105
char = n;code = 110
char = ;code = 32
char = p;code = 112
char = r;code = 114
char = i;code = 105
char = m;code = 109
char = a;code = 97
char = r;code = 114
char = y;code = 121
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char = c;code = 99
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = u;code = 117
char = r;code = 114
char = e;code = 101
char = s;code = 115
char = ;code = 32
char = o;code = 111
char = f;code = 102
char = ;code = 32
char = a;code = 97
char = d;code = 100
char = u;code = 117
char = l;code = 108
char = t;code = 116
char = ;code = 32
char = r;code = 114
char = a;code = 97
char = t;code = 116
char = ;code = 32
char = h;code = 104
char = e;code = 101
char = p;code = 112
char = a;code = 97
char = t;code = 116
char = o;code = 111
char = c;code = 99
char = y;code = 121
char = t;code = 116
char = e;code = 101
char = s;code = 115
char = .;code = 46
result sql = Potentiation of chlorinated hydrocarbon toxicity by 2,5-hexanedione in primary cultures of adult rat hepatocytes.
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result sql = Primary cultures of adult rat hepatocytes were used to investigate potentiation of halocarbon-induced hepatotoxicity by aliphatic ketones. Male Sprague-Dawley rats were pretreated with corn oil or 2,5-hexanedione (HD; 15 mmol/kg, po) in corn oil. Eighteen hours later the hepatocytes were isolated and cultured in Williams' Medium E and exposed to several concentrations of the hepatotoxicants carbon tetrachloride, chloroform, deutero-chloroform, or 1,1,2-trichloroethane. The cytotoxicity of these halocarbons as measured by release of the cytosolic enzyme lactate dehydrogenase into the culture medium was both time- and concentration-dependent. Halocarbon-induced cytotoxicity was exacerbated in cells isolated from HD-pretreated rats with significant increases in LDH release over cells isolated from corn oil-pretreated rats. In addition, chloroform was significantly more toxic than deutero-chloroform in hepatocytes from either corn oil- or HD-pretreated rats. Primary monolayer cultures were useful for studying ketone-induced potentiation, halocarbon-induced hepatocellular toxicity, and the mechanisms by which these effects occur.
Publication: Fundam Appl Toxicol 1983 Jan-Feb ;3(1)::22-6.
Publication Date: 1983 Jan-Feb
Study Author(s): Jernigan, J D;Pounds, J G;Harbison, R D;
Institution:
Shortcut link to this study:
Publication Date: 1983 Jan-Feb
Study Author(s): Jernigan, J D;Pounds, J G;Harbison, R D;
Institution:
Shortcut link to this study:
Primary cultures of adult rat hepatocytes were used to investigate potentiation of halocarbon-induced hepatotoxicity by aliphatic ketones. Male Sprague-Dawley rats were pretreated with corn oil or 2,5-hexanedione (HD; 15 mmol/kg, po) in corn oil. Eighteen hours later the hepatocytes were isolated and cultured in Williams' Medium E and exposed to several concentrations of the hepatotoxicants carbon tetrachloride, chloroform, deutero-chloroform, or 1,1,2-trichloroethane. The cytotoxicity of these halocarbons as measured by release of the cytosolic enzyme lactate dehydrogenase into the culture medium was both time- and concentration-dependent. Halocarbon-induced cytotoxicity was exacerbated in cells isolated from HD-pretreated rats with significant increases in LDH release over cells isolated from corn oil-pretreated rats. In addition, chloroform was significantly more toxic than deutero-chloroform in hepatocytes from either corn oil- or HD-pretreated rats. Primary monolayer cultures were useful for studying ketone-induced potentiation, halocarbon-induced hepatocellular toxicity, and the mechanisms by which these effects occur.
PMID: 6884620
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