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char = o;code = 111
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char = o;code = 111
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char = d;code = 100
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char = t;code = 116
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char = m;code = 109
char = a;code = 97
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char = f;code = 102
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char = n;code = 110
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char = d;code = 100
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char = r;code = 114
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char = >;code = 62
result sql = The influence of (+)-catechin (10 mg/100 g daily) and 0-(beta-hydroxyethyl) rutosides (50 mg/100 g daily) on the metabolism and crosslinking of collagen was studied in male albino rats. Compared to controls, the total activity of 3H-hydroxyproline in the dermal soluble collagen did not differ appreciably while the urinary total activity of 3H-hydroxyproline was significantly lowered. When the total activities of both soluble and insoluble collagens are expressed as a percentage of the sum of both, the registered activity was less in soluble and more in salt-insoluble collagen at 12 ans 120 h after the administration of 3H-proline in the treated group. Bioflavonoids were found to decrease the reversibility of neutral salt-soluble collagen gel and solubility of acid-insoluble collagen to denaturing agents. The subunit pattern of neutral salt-soluble collagen on sodium dodecylsulphate polyacrylamide gels revealed a decrease of alpha/beta ratio in bioflavonoids treated animals. The results of the present study indicate that the synthesis of collagen is unaffected, the crosslinking of collagen is promoted and the degradation of soluble collagen is decreased in the bioflavonoids treated groups.
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char = f;code = 102
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char = o;code = 111
char = f;code = 102
char = l;code = 108
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char = o;code = 111
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char = o;code = 111
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char = e;code = 101
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result sql = Influence of bioflavonoids on the metabolism and crosslinking of collagen.
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char = d;code = 100
char = s;code = 115
char = ;code = 32
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char = r;code = 114
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char = a;code = 97
char = t;code = 116
char = e;code = 101
char = d;code = 100
char = ;code = 32
char = g;code = 103
char = r;code = 114
char = o;code = 111
char = u;code = 117
char = p;code = 112
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result sql = The influence of (+)-catechin (10 mg/100 g daily) and 0-(beta-hydroxyethyl) rutosides (50 mg/100 g daily) on the metabolism and crosslinking of collagen was studied in male albino rats. Compared to controls, the total activity of 3H-hydroxyproline in the dermal soluble collagen did not differ appreciably while the urinary total activity of 3H-hydroxyproline was significantly lowered. When the total activities of both soluble and insoluble collagens are expressed as a percentage of the sum of both, the registered activity was less in soluble and more in salt-insoluble collagen at 12 ans 120 h after the administration of 3H-proline in the treated group. Bioflavonoids were found to decrease the reversibility of neutral salt-soluble collagen gel and solubility of acid-insoluble collagen to denaturing agents. The subunit pattern of neutral salt-soluble collagen on sodium dodecylsulphate polyacrylamide gels revealed a decrease of alpha/beta ratio in bioflavonoids treated animals. The results of the present study indicate that the synthesis of collagen is unaffected, the crosslinking of collagen is promoted and the degradation of soluble collagen is decreased in the bioflavonoids treated groups.
Publication: Ital. J. Biochem. 1981 Jul-Aug ;30(4)::259-70.
Publication Date: 1981 Jul-Aug
Study Author(s): Rao, C N;Rao, V H;Steinmann, B;
Institution:
Shortcut link to this study:
Publication Date: 1981 Jul-Aug
Study Author(s): Rao, C N;Rao, V H;Steinmann, B;
Institution:
Shortcut link to this study:
The influence of (+)-catechin (10 mg/100 g daily) and 0-(beta-hydroxyethyl) rutosides (50 mg/100 g daily) on the metabolism and crosslinking of collagen was studied in male albino rats. Compared to controls, the total activity of 3H-hydroxyproline in the dermal soluble collagen did not differ appreciably while the urinary total activity of 3H-hydroxyproline was significantly lowered. When the total activities of both soluble and insoluble collagens are expressed as a percentage of the sum of both, the registered activity was less in soluble and more in salt-insoluble collagen at 12 ans 120 h after the administration of 3H-proline in the treated group. Bioflavonoids were found to decrease the reversibility of neutral salt-soluble collagen gel and solubility of acid-insoluble collagen to denaturing agents. The subunit pattern of neutral salt-soluble collagen on sodium dodecylsulphate polyacrylamide gels revealed a decrease of alpha/beta ratio in bioflavonoids treated animals. The results of the present study indicate that the synthesis of collagen is unaffected, the crosslinking of collagen is promoted and the degradation of soluble collagen is decreased in the bioflavonoids treated groups.
PMID: 7298310
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